The Genetics of Congenital Amusia (Tone Deafness): A Family-Aggregation Study. Peretz, I., Cummings, S., & Dubé, M. American Journal of Human Genetics, 81(3):582–588, September, 2007. ![The Genetics of Congenital Amusia (Tone Deafness): A Family-Aggregation Study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Congenital amusia (commonly known as “tone deafness”) is a lifelong impairment of music perception that affects 4% of the population. To estimate whether congenital amusia can be genetically transmitted, its prevalence was quantified by direct auditory testing of 71 members of 9 large families of amusic probands, as well as of 75 members of 10 control families. The results confirm that congenital amusia is expressed by a deficit in processing musical pitch but not musical time and also show that the pitch disorder has a hereditary component. In amusic families, 39% of first-degree relatives have the same cognitive disorder, whereas only 3% have it in the control families. The identification of multiplex families with a high relative risk of experiencing a musical pitch deficit (λs=10.8; 95% confidence interval 8–13.5) enables the mapping of genetic loci for hereditary amusia.
@article{peretz_genetics_2007,
title = {The {Genetics} of {Congenital} {Amusia} ({Tone} {Deafness}): {A} {Family}-{Aggregation} {Study}},
volume = {81},
issn = {0002-9297},
shorttitle = {The {Genetics} of {Congenital} {Amusia} ({Tone} {Deafness})},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950825/},
abstract = {Congenital amusia (commonly known as “tone deafness”) is a lifelong impairment of music perception that affects 4\% of the population. To estimate whether congenital amusia can be genetically transmitted, its prevalence was quantified by direct auditory testing of 71 members of 9 large families of amusic probands, as well as of 75 members of 10 control families. The results confirm that congenital amusia is expressed by a deficit in processing musical pitch but not musical time and also show that the pitch disorder has a hereditary component. In amusic families, 39\% of first-degree relatives have the same cognitive disorder, whereas only 3\% have it in the control families. The identification of multiplex families with a high relative risk of experiencing a musical pitch deficit (λs=10.8; 95\% confidence interval 8–13.5) enables the mapping of genetic loci for hereditary amusia.},
number = {3},
urldate = {2019-01-12},
journal = {American Journal of Human Genetics},
author = {Peretz, Isabelle and Cummings, Stéphanie and Dubé, Marie-Pierre},
month = sep,
year = {2007},
pmid = {17701903},
pmcid = {PMC1950825},
pages = {582--588},
}
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