@article{
 title = {Understanding the Determinants of Exceptional Longevity},
 type = {article},
 year = {2003},
 identifiers = {[object Object]},
 keywords = {*Longevity,Animals,Genes,Humans,Life Expectancy,Non-U.S. Gov't,P.H.S.,Phenotype,Research Support,U.S. Gov't},
 pages = {445-449},
 volume = {139},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12965974},
 id = {c5bf1b72-7d77-39e3-9bef-27367ae5c742},
 created = {2017-06-19T13:42:01.681Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:42:01.863Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>        <m:bold>From Duplicate 2 ( </m:bold>        <m:bold>          </m:bold><m:bold><m:italic>Understanding the determinants of exceptional longevity</m:italic></m:bold><m:bold>        </m:bold>        <m:bold> - Perls, T; Terry, D )<m:linebreak/>        </m:bold>        <m:linebreak/>1539-3704<m:linebreak/>Journal Article<m:linebreak/>Review<m:linebreak/>        <m:linebreak/>      </m:note>},
 abstract = {Centenarians represent an extreme of life expectancy. They achieve their exceptional longevity in part by lacking genetic variations linked to premature death. Pedigree studies have shown a substantial familial component in the ability to survive to extreme old age, and a recent study demonstrated a locus on chromosome 4 linked to exceptional longevity, indicating the likely existence of at least one longevity-enabling gene in humans. The children of centenarians have markedly reduced relative risks for age-related diseases, particularly heart disease, hypertension, and diabetes, and are a promising model for genetic and phenotypic studies of 1) aging slowly relative to the general population and 2) the delay of and perhaps escape from important age-related diseases. These studies and those of other mammals and lower organisms show great promise for the delineation of important environmental and genetic determinants of aging well.},
 bibtype = {article},
 author = {Perls, Thomas and Terry, Dellara},
 journal = {Ann Intern Med},
 number = {5 Pt 2}
}

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They achieve their exceptional longevity in part by lacking genetic variations linked to premature death. Pedigree studies have shown a substantial familial component in the ability to survive to extreme old age, and a recent study demonstrated a locus on chromosome 4 linked to exceptional longevity, indicating the likely existence of at least one longevity-enabling gene in humans. The children of centenarians have markedly reduced relative risks for age-related diseases, particularly heart disease, hypertension, and diabetes, and are a promising model for genetic and phenotypic studies of 1) aging slowly relative to the general population and 2) the delay of and perhaps escape from important age-related diseases. These studies and those of other mammals and lower organisms show great promise for the delineation of important environmental and genetic determinants of aging well.","bibtype":"article","author":"Perls, Thomas and Terry, Dellara","journal":"Ann Intern Med","number":"5 Pt 2","bibtex":"@article{\n title = {Understanding the Determinants of Exceptional Longevity},\n type = {article},\n year = {2003},\n identifiers = {[object Object]},\n keywords = {*Longevity,Animals,Genes,Humans,Life Expectancy,Non-U.S. Gov't,P.H.S.,Phenotype,Research Support,U.S. Gov't},\n pages = {445-449},\n volume = {139},\n websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12965974},\n id = {c5bf1b72-7d77-39e3-9bef-27367ae5c742},\n created = {2017-06-19T13:42:01.681Z},\n file_attached = {true},\n profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},\n group_id = {b2078731-0913-33b9-8902-a53629a24e83},\n last_modified = {2017-06-19T13:42:01.863Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n source_type = {Journal Article},\n notes = {<m:note> <m:bold>From Duplicate 2 ( </m:bold> <m:bold> </m:bold><m:bold><m:italic>Understanding the determinants of exceptional longevity</m:italic></m:bold><m:bold> </m:bold> <m:bold> - Perls, T; Terry, D )<m:linebreak/> </m:bold> <m:linebreak/>1539-3704<m:linebreak/>Journal Article<m:linebreak/>Review<m:linebreak/> <m:linebreak/> </m:note>},\n abstract = {Centenarians represent an extreme of life expectancy. 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