A Randomized Trial of Oral Tranexamic Acid With Fluocinolone-Based Triple Cream Versus Fluocinolone Based Triple Cream Alone for the Treatment of Melasma. Perveen, S., Rubin, A., Berger, L., Xiong, W., Waqas, N., Sharif, S., & Rao, B. J Drugs Dermatol, 21(3):321–322, March, 2022.
doi  abstract   bibtex   
Oral tranexamic acid (TXA) is a relatively new treatment option for melasma. It is thought to reduce hyperpigmentation through inhibition of the plasminogen/plasmin pathway with resulting decreases in epidermal melanocyte tyrosinase activity, inflammatory mediators, dermal neovascularization, and mast cell numbers.
@article{perveen_randomized_2022,
	title = {A {Randomized} {Trial} of {Oral} {Tranexamic} {Acid} {With} {Fluocinolone}-{Based} {Triple} {Cream} {Versus} {Fluocinolone} {Based} {Triple} {Cream} {Alone} for the {Treatment} of {Melasma}},
	volume = {21},
	copyright = {All rights reserved},
	issn = {1545-9616 (Print) 1545-9616},
	doi = {10.36849/jdd.6099},
	abstract = {Oral tranexamic acid (TXA) is a relatively new treatment option for melasma. It is thought to reduce hyperpigmentation through inhibition of the plasminogen/plasmin pathway with resulting decreases in epidermal melanocyte tyrosinase activity, inflammatory mediators, dermal neovascularization, and mast cell numbers.},
	language = {eng},
	number = {3},
	journal = {J Drugs Dermatol},
	author = {Perveen, S. and Rubin, A. and Berger, L. and Xiong, W. and Waqas, N. and Sharif, S. and Rao, B.},
	month = mar,
	year = {2022},
	pages = {321--322},
}

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