Is TH17 immunity altered by chronically perceived stress?. Peters, E., Snaga, W., Liezmann, C., Schmidt-Rose, T., Schweiger, D., Rose, M., Klapp, B., & Kruse, J. Brain, Behavior, and Immunity, 2013.
doi  abstract   bibtex   
Inflammatory injury requires tissue regeneration, a process hampered by chronic stress exposure in many experimental settings. The reported shift of the immune balance towards adaptive humoral immunity reported in chronically stressed mice and man may be the functional link. We here report results obtained in females exposed to exam stress. In these individuals subjective perception of anxiety (state and trait anxiety index - STAI) as well as a nervous mood (multidimensional mood questionnaire - MDMQ) prominently characterized chronic stress perception throughout a twelve week examination preparation and execution period. During the same time period exam participants displayed reduced morning serum cortisol levels prior to exam (exam preparation) and during exam execution when compared to expression levels in participants not exposed to exam stress. They also showed significantly increased serum level of the neurotrophin brain derived neurotrophic factor (BDNF). Correspondingly, the summary score for cytokines conducting the TH17 response differed significantly between exam participants and controls during exam preparation. These results link decreased hypothalamus pituitary adrenal axis function during chronic stress exposure with increased neurotrophin expression and TH17 dominated immunity. Future research will determine relevance for chronic inflammatory diseases driven by respective immune-dysfunction.
@article{peters_is_2013,
	title = {Is {TH17} immunity altered by chronically perceived stress?},
	issn = {08891591},
	doi = {10.1016/j.bbi.2013.01.049},
	abstract = {Inflammatory injury requires tissue regeneration, a process hampered by chronic stress exposure in many experimental settings. The reported shift of the immune balance towards adaptive humoral immunity reported in chronically stressed mice and man may be the functional link. We here report results obtained in females exposed to exam stress. In these individuals subjective perception of anxiety (state and trait anxiety index - STAI) as well as a nervous mood (multidimensional mood questionnaire - MDMQ) prominently characterized chronic stress perception throughout a twelve week examination preparation and execution period. During the same time period exam participants displayed reduced morning serum cortisol levels prior to exam (exam preparation) and during exam execution when compared to expression levels in participants not exposed to exam stress. They also showed significantly increased serum level of the neurotrophin brain derived neurotrophic factor (BDNF). Correspondingly, the summary score for cytokines conducting the TH17 response differed significantly between exam participants and controls during exam preparation. These results link decreased hypothalamus pituitary adrenal axis function during chronic stress exposure with increased neurotrophin expression and TH17 dominated immunity. Future research will determine relevance for chronic inflammatory diseases driven by respective immune-dysfunction.},
	journal = {Brain, Behavior, and Immunity},
	author = {Peters, E.M.J. and Snaga, W. and Liezmann, C. and Schmidt-Rose, T. and Schweiger, D. and Rose, M. and Klapp, B.F. and Kruse, J.},
	year = {2013},
}

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