@inproceedings{Petrellis2021,
abstract = {Helminth infection conditions lung macrophages in the long term, but little is known about how helminths affect the lung macrophage responses to respiratory viral coinfection. While comparing BALB/c and C57BL/6 mice, we found that helminth infection in C57BL/6 mice resulted in enhanced permissiveness to a subsequent infection with murid gammaherpesvirus 4 (MuHV-4), and that viral early tropism was mainly restricted to lung macrophages. Helminth infection resulted in enhanced type 2 airway inflammation and M(IL-4) polarization of interstitial macrophages (IntMs) in C57BL/6 mice, associated with an IL-4R$\alpha$-dependent disappearance reaction of alveolar macrophages (AlvMs) and enriched monocyte-derived IntMs proportions. Competent IL-4R$\alpha$ responsiveness or intra-tracheal instillation of recombinant IL-4 or IL-13 significantly resulted in reduced numbers of AlvMs and enriched IntMs as well as increased permissiveness to MuHV-4 infection, which was restricted to AlvMs. Thus, direct IL-4R$\alpha$ signaling during helminth infection affects macrophage permissiveness to gammaherpesvirus infection.},
author = {Petrellis, Georgios and Rolot, Marion and Preure, Amira and Wathieu, Caroline and Dougall, Annetter and Chetty, Alisha and Chariot, Alain and Hornsell, William and Dewals, Benjamin G},
booktitle = {Belgian Society of Parasitology {\&} Protistology Annual Scientific Meeting},
keywords = {abstract},
mendeley-tags = {abstract},
month = {nov},
title = {{Il-4r$\alpha$-dependent lung macrophage response to helminth increases permissiveness to gammaherpesvirus infection}},
url = {https://hdl.handle.net/2268/267632 https://orbi.uliege.be/handle/2268/267632},
year = {2021}
}

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Helminth infection resulted in enhanced type 2 airway inflammation and M(IL-4) polarization of interstitial macrophages (IntMs) in C57BL/6 mice, associated with an IL-4R$α$-dependent disappearance reaction of alveolar macrophages (AlvMs) and enriched monocyte-derived IntMs proportions. Competent IL-4R$α$ responsiveness or intra-tracheal instillation of recombinant IL-4 or IL-13 significantly resulted in reduced numbers of AlvMs and enriched IntMs as well as increased permissiveness to MuHV-4 infection, which was restricted to AlvMs. Thus, direct IL-4R$α$ signaling during helminth infection affects macrophage permissiveness to gammaherpesvirus infection.","author":[{"propositions":[],"lastnames":["Petrellis"],"firstnames":["Georgios"],"suffixes":[]},{"propositions":[],"lastnames":["Rolot"],"firstnames":["Marion"],"suffixes":[]},{"propositions":[],"lastnames":["Preure"],"firstnames":["Amira"],"suffixes":[]},{"propositions":[],"lastnames":["Wathieu"],"firstnames":["Caroline"],"suffixes":[]},{"propositions":[],"lastnames":["Dougall"],"firstnames":["Annetter"],"suffixes":[]},{"propositions":[],"lastnames":["Chetty"],"firstnames":["Alisha"],"suffixes":[]},{"propositions":[],"lastnames":["Chariot"],"firstnames":["Alain"],"suffixes":[]},{"propositions":[],"lastnames":["Hornsell"],"firstnames":["William"],"suffixes":[]},{"propositions":[],"lastnames":["Dewals"],"firstnames":["Benjamin","G"],"suffixes":[]}],"booktitle":"Belgian Society of Parasitology & Protistology Annual Scientific Meeting","keywords":"abstract","mendeley-tags":"abstract","month":"nov","title":"Il-4r$α$-dependent lung macrophage response to helminth increases permissiveness to gammaherpesvirus infection","url":"https://hdl.handle.net/2268/267632 https://orbi.uliege.be/handle/2268/267632","year":"2021","bibtex":"@inproceedings{Petrellis2021,\r\nabstract = {Helminth infection conditions lung macrophages in the long term, but little is known about how helminths affect the lung macrophage responses to respiratory viral coinfection. While comparing BALB/c and C57BL/6 mice, we found that helminth infection in C57BL/6 mice resulted in enhanced permissiveness to a subsequent infection with murid gammaherpesvirus 4 (MuHV-4), and that viral early tropism was mainly restricted to lung macrophages. Helminth infection resulted in enhanced type 2 airway inflammation and M(IL-4) polarization of interstitial macrophages (IntMs) in C57BL/6 mice, associated with an IL-4R$\\alpha$-dependent disappearance reaction of alveolar macrophages (AlvMs) and enriched monocyte-derived IntMs proportions. Competent IL-4R$\\alpha$ responsiveness or intra-tracheal instillation of recombinant IL-4 or IL-13 significantly resulted in reduced numbers of AlvMs and enriched IntMs as well as increased permissiveness to MuHV-4 infection, which was restricted to AlvMs. Thus, direct IL-4R$\\alpha$ signaling during helminth infection affects macrophage permissiveness to gammaherpesvirus infection.},\r\nauthor = {Petrellis, Georgios and Rolot, Marion and Preure, Amira and Wathieu, Caroline and Dougall, Annetter and Chetty, Alisha and Chariot, Alain and Hornsell, William and Dewals, Benjamin G},\r\nbooktitle = {Belgian Society of Parasitology {\\&} Protistology Annual Scientific Meeting},\r\nkeywords = {abstract},\r\nmendeley-tags = {abstract},\r\nmonth = {nov},\r\ntitle = {{Il-4r$\\alpha$-dependent lung macrophage response to helminth increases permissiveness to gammaherpesvirus infection}},\r\nurl = {https://hdl.handle.net/2268/267632 https://orbi.uliege.be/handle/2268/267632},\r\nyear = {2021}\r\n}\r\n","author_short":["Petrellis, G.","Rolot, M.","Preure, A.","Wathieu, C.","Dougall, A.","Chetty, A.","Chariot, A.","Hornsell, W.","Dewals, B. G"],"key":"Petrellis2021","id":"Petrellis2021","bibbaseid":"petrellis-rolot-preure-wathieu-dougall-chetty-chariot-hornsell-etal-il4rdependentlungmacrophageresponsetohelminthincreasespermissivenesstogammaherpesvirusinfection-2021","role":"author","urls":{"Paper":"https://hdl.handle.net/2268/267632 https://orbi.uliege.be/handle/2268/267632"},"keyword":["abstract"],"metadata":{"authorlinks":{}}},"bibtype":"inproceedings","biburl":"https://drive.google.com/uc?export=download&id=1-JLqZ7RwZ3VC2d6ErLGHAtOeMRS_7GCz","dataSources":["Krmt6gt9ktB2s6ARh"],"keywords":["abstract"],"search_terms":["dependent","lung","macrophage","response","helminth","increases","permissiveness","gammaherpesvirus","infection","petrellis","rolot","preure","wathieu","dougall","chetty","chariot","hornsell","dewals"],"title":"Il-4r$α$-dependent lung macrophage response to helminth increases permissiveness to gammaherpesvirus infection","year":2021}