@article{phanStructureUnprecedentedGQuadruplex2007,
  title = {Structure of an {{Unprecedented G-Quadruplex Scaffold}} in the {{Human}} {\emph{c-Kit}} {{Promoter}}},
  author = {Phan, Anh Tu{\^a}n and Kuryavyi, Vitaly and Burge, Sarah and Neidle, Stephen and Patel, Dinshaw J.},
  year = {2007},
  month = apr,
  journal = {Journal of the American Chemical Society},
  volume = {129},
  number = {14},
  pages = {4386--4392},
  issn = {0002-7863, 1520-5126},
  doi = {10.1021/ja068739h},
  urldate = {2020-11-09},
  abstract = {The c-kit oncogene is an important target in the treatment of gastrointestinal tumors. A potential approach to inhibition of the expression of this gene involves selective stabilization of G-quadruplex structures that may be induced to form in the c-kit promoter region. Here we report on the structure of an unprecedented intramolecular G-quadruplex formed by a G-rich sequence in the c-kit promoter in K+ solution. The structure represents a new folding topology with several unique features. Most strikingly, an isolated guanine is involved in G-tetrad core formation, despite the presence of four three-guanine tracts. There are four loops: two single-residue double-chain-reversal loops, a two-residue loop, and a five-residue stem-loop, which contain base-pairing alignments. This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit.},
  langid = {english},
  file = {E:\UBCloud\Zotero\storage\54XRFRDU\Phan et al. - 2007 - Structure of an Unprecedented G-Quadruplex Scaffol.pdf}
}

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