@article{Phan2005,
	title = {Small-molecule interaction with a five-guanine-tract {G}-quadruplex structure from the human {MYC} promoter.},
	volume = {1},
	issn = {1552-4450},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/16408022 http://dx.doi.org/10.1038/nchembio723},
	abstract = {It has been widely accepted that DNA can adopt other biologically relevant structures beside the Watson-Crick double helix. One recent important example is the guanine-quadruplex (G-quadruplex) structure formed by guanine tracts found in the MYC (or c-myc) promoter region, which regulates the transcription of the MYC oncogene. Stabilization of this G-quadruplex by ligands, such as the cationic porphyrin TMPyP4, decreases the transcriptional level of MYC. Here, we report the first structure of a DNA fragment containing five guanine tracts from this region. An unusual G-quadruplex fold, which was derived from NMR restraints using unambiguous model-independent resonance assignment approaches, involves a core of three stacked guanine tetrads formed by four parallel guanine tracts with all anti guanines and a snapback 3'-end syn guanine. We have determined the structure of the complex formed between this G-quadruplex and TMPyP4. This structural information, combined with details of small-molecule interaction, provides a platform for the design of anticancer drugs targeting multi-guanine-tract sequences that are found in the MYC and other oncogenic promoters, as well as in telomeres.},
	number = {3},
	journal = {Nature Chemical Biology},
	author = {Phan, Anh Tuân Tuan Tuân and Kuryavyi, Vitaly and Gaw, Hai Yan and Patel, Dinshaw J},
	year = {2005},
	pmid = {16408022},
	note = {tex.ids= phanSmallmoleculeInteractionFiveguaninetract2005
publisher: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. phantuan@mskcc.org},
	pages = {167--173},
}

{"_id":"jTRw4h4LxWsbyn7mi","bibbaseid":"phan-kuryavyi-gaw-patel-smallmoleculeinteractionwithafiveguaninetractgquadruplexstructurefromthehumanmycpromoter-2005","author_short":["Phan, A. T. T. T.","Kuryavyi, V.","Gaw, H. Y.","Patel, D. J"],"bibdata":{"bibtype":"article","type":"article","title":"Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.","volume":"1","issn":"1552-4450","url":"http://www.ncbi.nlm.nih.gov/pubmed/16408022 http://dx.doi.org/10.1038/nchembio723","abstract":"It has been widely accepted that DNA can adopt other biologically relevant structures beside the Watson-Crick double helix. One recent important example is the guanine-quadruplex (G-quadruplex) structure formed by guanine tracts found in the MYC (or c-myc) promoter region, which regulates the transcription of the MYC oncogene. Stabilization of this G-quadruplex by ligands, such as the cationic porphyrin TMPyP4, decreases the transcriptional level of MYC. Here, we report the first structure of a DNA fragment containing five guanine tracts from this region. An unusual G-quadruplex fold, which was derived from NMR restraints using unambiguous model-independent resonance assignment approaches, involves a core of three stacked guanine tetrads formed by four parallel guanine tracts with all anti guanines and a snapback 3'-end syn guanine. We have determined the structure of the complex formed between this G-quadruplex and TMPyP4. This structural information, combined with details of small-molecule interaction, provides a platform for the design of anticancer drugs targeting multi-guanine-tract sequences that are found in the MYC and other oncogenic promoters, as well as in telomeres.","number":"3","journal":"Nature Chemical Biology","author":[{"propositions":[],"lastnames":["Phan"],"firstnames":["Anh","Tuân","Tuan","Tuân"],"suffixes":[]},{"propositions":[],"lastnames":["Kuryavyi"],"firstnames":["Vitaly"],"suffixes":[]},{"propositions":[],"lastnames":["Gaw"],"firstnames":["Hai","Yan"],"suffixes":[]},{"propositions":[],"lastnames":["Patel"],"firstnames":["Dinshaw","J"],"suffixes":[]}],"year":"2005","pmid":"16408022","note":"tex.ids= phanSmallmoleculeInteractionFiveguaninetract2005 publisher: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. phantuan@mskcc.org","pages":"167–173","bibtex":"@article{Phan2005,\n\ttitle = {Small-molecule interaction with a five-guanine-tract {G}-quadruplex structure from the human {MYC} promoter.},\n\tvolume = {1},\n\tissn = {1552-4450},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/16408022 http://dx.doi.org/10.1038/nchembio723},\n\tabstract = {It has been widely accepted that DNA can adopt other biologically relevant structures beside the Watson-Crick double helix. One recent important example is the guanine-quadruplex (G-quadruplex) structure formed by guanine tracts found in the MYC (or c-myc) promoter region, which regulates the transcription of the MYC oncogene. Stabilization of this G-quadruplex by ligands, such as the cationic porphyrin TMPyP4, decreases the transcriptional level of MYC. Here, we report the first structure of a DNA fragment containing five guanine tracts from this region. An unusual G-quadruplex fold, which was derived from NMR restraints using unambiguous model-independent resonance assignment approaches, involves a core of three stacked guanine tetrads formed by four parallel guanine tracts with all anti guanines and a snapback 3'-end syn guanine. We have determined the structure of the complex formed between this G-quadruplex and TMPyP4. This structural information, combined with details of small-molecule interaction, provides a platform for the design of anticancer drugs targeting multi-guanine-tract sequences that are found in the MYC and other oncogenic promoters, as well as in telomeres.},\n\tnumber = {3},\n\tjournal = {Nature Chemical Biology},\n\tauthor = {Phan, Anh Tuân Tuan Tuân and Kuryavyi, Vitaly and Gaw, Hai Yan and Patel, Dinshaw J},\n\tyear = {2005},\n\tpmid = {16408022},\n\tnote = {tex.ids= phanSmallmoleculeInteractionFiveguaninetract2005\npublisher: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. phantuan@mskcc.org},\n\tpages = {167--173},\n}\n\n","author_short":["Phan, A. T. T. T.","Kuryavyi, V.","Gaw, H. Y.","Patel, D. 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