Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution †. Phan, A. T., Kuryavyi, V., Luu, K. N., & Patel, D. J. Nucleic Acids Research, 35(19):6517–6525, October, 2007. tex.ids= Phan2007, phanStructureTwoIntramolecular2007 ISBN: 1362-4962 (Electronic) 0305-1048 (Linking)![Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution † [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K+ solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one doublechain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds.
@article{phan_structure_2007,
title = {Structure of two intramolecular {G}-quadruplexes formed by natural human telomere sequences in {K} + solution †},
volume = {35},
issn = {1362-4962, 0305-1048},
url = {https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkm706},
doi = {10.1093/nar/gkm706},
abstract = {Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K+ solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one doublechain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds.},
language = {en},
number = {19},
urldate = {2020-11-09},
journal = {Nucleic Acids Research},
author = {Phan, Anh Tuân and Kuryavyi, Vitaly and Luu, Kim Ngoc and Patel, Dinshaw J.},
month = oct,
year = {2007},
pmid = {17895279},
note = {tex.ids= Phan2007, phanStructureTwoIntramolecular2007
ISBN: 1362-4962 (Electronic) 0305-1048 (Linking)},
keywords = {Base Sequence, Biomolecular, Cations, DNA, DNA: chemistry, G-Quadruplexes, Humans, Models, Molecular, Nuclear Magnetic Resonance, Nucleic Acid, Potassium, Potassium: chemistry, Repetitive Sequences, Solutions, Telomere, Telomere: chemistry},
pages = {6517--6525},
}
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