@article{Phillips2004,
  title = {{{DNA}} Binding of an Organic Dppz-Based Intercalator.},
  author = {Phillips, Tim and Haq, Ihtshamul and Meijer, Anthony J H M and Adams, Harry and Soutar, Ian and Swanson, Linda and Sykes, Matthew J and a Thomas, Jim},
  year = {2004},
  month = nov,
  journal = {Biochemistry},
  volume = {43},
  number = {43},
  eprint = {15504028},
  eprinttype = {pubmed},
  pages = {13657--65},
  issn = {0006-2960},
  doi = {10.1021/bi049146r},
  abstract = {An improved synthesis of a water-soluble derivative of dipyrido[3,2-a:2',3'-c]phenazine (dppz) is reported. The structures of both dppz and the cation ethylene-bipyridyldiylium-phenazine dinitrate [[1][(PF(6))(2)]] have been obtained via X-ray crystallography. Metal complex derivatives of dppz are very well studied. However, using the water soluble [1][(NO(3))(2)], the nature of the interaction of a simple dppz unit with duplex DNA has been investigated for the first time. In both organic solvents and water, 1 displays unstructured luminescence, assigned to an intramolecular charge transfer. The emission is quenched on binding to natural and synthetic duplex DNA, including poly(dA).poly(dT). A variety of techniques reveal that the cation binds to DNA with an affinity comparable to those of many metal dppz complexes, via an intercalative binding mode.},
  pmid = {15504028},
  keywords = {\#nosource,Binding Sites,Biomolecular,Calorimetry,Crystallography,DNA,DNA: chemistry,Fast Atom Bombardment,Fluorescence,Fluorescence Polarization,Intercalating Agents,Intercalating Agents: chemistry,Luminescent Measurements,Mass,Nuclear Magnetic Resonance,Phenazines,Phenazines: chemistry,Polyribonucleotides,Polyribonucleotides: chemistry,Spectrometry,Structure-Activity Relationship,Thermodynamics,Viscosity,X-Ray}
}

{"_id":"ciFNnx7mTfRwtYtn2","bibbaseid":"phillips-haq-meijer-adams-soutar-swanson-sykes-athomas-dnabindingofanorganicdppzbasedintercalator-2004","author_short":["Phillips, T.","Haq, I.","Meijer, A. J H M","Adams, H.","Soutar, I.","Swanson, L.","Sykes, M. J","a Thomas, J."],"bibdata":{"bibtype":"article","type":"article","title":"DNA Binding of an Organic Dppz-Based Intercalator.","author":[{"propositions":[],"lastnames":["Phillips"],"firstnames":["Tim"],"suffixes":[]},{"propositions":[],"lastnames":["Haq"],"firstnames":["Ihtshamul"],"suffixes":[]},{"propositions":[],"lastnames":["Meijer"],"firstnames":["Anthony","J","H","M"],"suffixes":[]},{"propositions":[],"lastnames":["Adams"],"firstnames":["Harry"],"suffixes":[]},{"propositions":[],"lastnames":["Soutar"],"firstnames":["Ian"],"suffixes":[]},{"propositions":[],"lastnames":["Swanson"],"firstnames":["Linda"],"suffixes":[]},{"propositions":[],"lastnames":["Sykes"],"firstnames":["Matthew","J"],"suffixes":[]},{"propositions":["a"],"lastnames":["Thomas"],"firstnames":["Jim"],"suffixes":[]}],"year":"2004","month":"November","journal":"Biochemistry","volume":"43","number":"43","eprint":"15504028","eprinttype":"pubmed","pages":"13657–65","issn":"0006-2960","doi":"10.1021/bi049146r","abstract":"An improved synthesis of a water-soluble derivative of dipyrido[3,2-a:2',3'-c]phenazine (dppz) is reported. The structures of both dppz and the cation ethylene-bipyridyldiylium-phenazine dinitrate [[1][(PF(6))(2)]] have been obtained via X-ray crystallography. Metal complex derivatives of dppz are very well studied. However, using the water soluble [1][(NO(3))(2)], the nature of the interaction of a simple dppz unit with duplex DNA has been investigated for the first time. In both organic solvents and water, 1 displays unstructured luminescence, assigned to an intramolecular charge transfer. The emission is quenched on binding to natural and synthetic duplex DNA, including poly(dA).poly(dT). A variety of techniques reveal that the cation binds to DNA with an affinity comparable to those of many metal dppz complexes, via an intercalative binding mode.","pmid":"15504028","keywords":"#nosource,Binding Sites,Biomolecular,Calorimetry,Crystallography,DNA,DNA: chemistry,Fast Atom Bombardment,Fluorescence,Fluorescence Polarization,Intercalating Agents,Intercalating Agents: chemistry,Luminescent Measurements,Mass,Nuclear Magnetic Resonance,Phenazines,Phenazines: chemistry,Polyribonucleotides,Polyribonucleotides: chemistry,Spectrometry,Structure-Activity Relationship,Thermodynamics,Viscosity,X-Ray","bibtex":"@article{Phillips2004,\n title = {{{DNA}} Binding of an Organic Dppz-Based Intercalator.},\n author = {Phillips, Tim and Haq, Ihtshamul and Meijer, Anthony J H M and Adams, Harry and Soutar, Ian and Swanson, Linda and Sykes, Matthew J and a Thomas, Jim},\n year = {2004},\n month = nov,\n journal = {Biochemistry},\n volume = {43},\n number = {43},\n eprint = {15504028},\n eprinttype = {pubmed},\n pages = {13657--65},\n issn = {0006-2960},\n doi = {10.1021/bi049146r},\n abstract = {An improved synthesis of a water-soluble derivative of dipyrido[3,2-a:2',3'-c]phenazine (dppz) is reported. The structures of both dppz and the cation ethylene-bipyridyldiylium-phenazine dinitrate [[1][(PF(6))(2)]] have been obtained via X-ray crystallography. Metal complex derivatives of dppz are very well studied. However, using the water soluble [1][(NO(3))(2)], the nature of the interaction of a simple dppz unit with duplex DNA has been investigated for the first time. In both organic solvents and water, 1 displays unstructured luminescence, assigned to an intramolecular charge transfer. The emission is quenched on binding to natural and synthetic duplex DNA, including poly(dA).poly(dT). A variety of techniques reveal that the cation binds to DNA with an affinity comparable to those of many metal dppz complexes, via an intercalative binding mode.},\n pmid = {15504028},\n keywords = {\\#nosource,Binding Sites,Biomolecular,Calorimetry,Crystallography,DNA,DNA: chemistry,Fast Atom Bombardment,Fluorescence,Fluorescence Polarization,Intercalating Agents,Intercalating Agents: chemistry,Luminescent Measurements,Mass,Nuclear Magnetic Resonance,Phenazines,Phenazines: chemistry,Polyribonucleotides,Polyribonucleotides: chemistry,Spectrometry,Structure-Activity Relationship,Thermodynamics,Viscosity,X-Ray}\n}\n\n","author_short":["Phillips, T.","Haq, I.","Meijer, A. J H M","Adams, H.","Soutar, I.","Swanson, L.","Sykes, M. 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