Synthetic genetic polymers capable of heredity and evolution. Pinheiro, V. B., Taylor, A. I., Cozens, C., Abramov, M., Renders, M., Zhang, S., Chaput, J. C., Wengel, J., Peak-Chew, S. S. S., McLaughlin, S. H., Herdewijn, P., & Holliger, P. Science (New York, N.Y.), 336(6079):341–4, April, 2012. tex.ids= pinheiroSyntheticGeneticPolymers2012, pinheiroSyntheticGeneticPolymers2012a![Synthetic genetic polymers capable of heredity and evolution. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage.
@article{Pinheiro2012,
title = {Synthetic genetic polymers capable of heredity and evolution.},
volume = {336},
issn = {1095-9203},
url = {http://www.sciencemag.org/cgi/doi/10.1126/science.1217622 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3362463&tool=pmcentrez&rendertype=abstract},
doi = {10.1126/science.1217622},
abstract = {Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage.},
number = {6079},
journal = {Science (New York, N.Y.)},
author = {Pinheiro, Vitor B. and Taylor, Alexander I. and Cozens, Christopher and Abramov, Mikhail and Renders, Marleen and Zhang, Su and Chaput, John C. and Wengel, Jesper and Peak-Chew, S.-Y. Sew-Yeu S.-Y. and McLaughlin, Stephen H. and Herdewijn, Piet and Holliger, Philipp},
month = apr,
year = {2012},
pmid = {22517858},
note = {tex.ids= pinheiroSyntheticGeneticPolymers2012, pinheiroSyntheticGeneticPolymers2012a},
keywords = {Aptamers, DNA, DNA-Directed DNA Polymerase, DNA-Directed DNA Polymerase: chemistry, DNA-Directed DNA Polymerase: genetics, DNA-Directed DNA Polymerase: metabolism, DNA: chemistry, DNA: genetics, Directed Molecular Evolution, Evolution, Genetic, Molecular, Molecular Mimicry, Nucleic Acids, Nucleic Acids: chemistry, Nucleic Acids: genetics, Nucleic Acids: metabolism, Nucleotide, Nucleotide: chemistry, Nucleotide: genetics, Nucleotide: metabolism, Polymers, Polymers: chemistry, Polymers: metabolism, RNA, RNA-Directed DNA Polymerase, RNA-Directed DNA Polymerase: chemistry, RNA-Directed DNA Polymerase: metabolism, RNA: chemistry, RNA: genetics, Reverse Transcription, Templates, Transcription},
pages = {341--4},
}
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