Direct determination of absolute molecular stereochemistry in gas phase by Coulomb explosion imaging. Pitzer, M., Kunitski, M., Johnson, A. S., Jahnke, T., Sann, H., Sturm, F., Schmidt, L. P. H., Schmidt-Böcking, H., Dörner, R., Stohner, J., Kiedrowski, J., Reggelin, M., Marquardt, S., Schießer, A., Berger, R., & Schöffler, M. S. Science, 341(6150):1096–1100, 2013.
doi  abstract   bibtex   
Bijvoet's method, which makes use of anomalous x-ray diffraction or dispersion, is the standard means of directly determining the absolute (stereochemical) configuration of molecules, but it requires crystalline samples and often proves challenging in structures exclusively comprising light atoms. Herein, we demonstrate a mass spectrometry approach that directly images the absolute configuration of individual molecules in the gas phase by cold target recoil ion momentum spectroscopy after laser ionization-induced Coulomb explosion. This technique is applied to the prototypical chiral molecule bromochlorofluoromethane and the isotopically chiral methane derivative bromodichloromethane.
@Article{pitzer13direct,
  author    = {Pitzer, Martin and Kunitski, Maksim and Johnson, Allan S. and Jahnke, Till and Sann, Hendrik and Sturm, Felix and Schmidt, Lothar Ph H. and Schmidt-B{\"{o}}cking, Horst and D{\"{o}}rner, Reinhard and Stohner, J\"urgen and Kiedrowski, Julia and Reggelin, Michael and Marquardt, Sebastian and Schie{\ss}er, Alexander and Berger, Robert and Sch{\"{o}}ffler, Markus S.},
  title     = {Direct determination of absolute molecular stereochemistry in gas phase by Coulomb explosion imaging.},
  journal   = {Science},
  year      = {2013},
  volume    = {341},
  number    = {6150},
  pages     = {1096--1100},
  abstract  = {Bijvoet's method, which makes use of anomalous x-ray diffraction or dispersion, is the standard means of directly determining the absolute (stereochemical) configuration of molecules, but it requires crystalline samples and often proves challenging in structures exclusively comprising light atoms. Herein, we demonstrate a mass spectrometry approach that directly images the absolute configuration of individual molecules in the gas phase by cold target recoil ion momentum spectroscopy after laser ionization-induced Coulomb explosion. This technique is applied to the prototypical chiral molecule bromochlorofluoromethane and the isotopically chiral methane derivative bromodichloromethane.},
  doi       = {10.1126/science.1240362},
  file      = {PitzerEtAl_DirectDeterminationStereochemistry_Science_2013.pdf:2013/PitzerEtAl_DirectDeterminationStereochemistry_Science_2013.pdf:PDF},
  optmonth  = sep,
  owner     = {fhufsky},
  pmid      = {24009390},
  timestamp = {2013.09.10},
}

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