Reactivation of ocular dominance plasticity in the adult visual cortex. Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W, & Maffei, L. Science, 298(5596):1248-51, 2002. doi abstract bibtex In young animals, monocular deprivation leads to an ocular dominance shift, whereas in adults after the critical period there is no such shift. Chondroitin sulphate proteoglycans (CSPGs) are components of the extracellular matrix (ECM) inhibitory for axonal sprouting. We tested whether the developmental maturation of the ECM is inhibitory for experience-dependent plasticity in the visual cortex. The organization of CSPGs into perineuronal nets coincided with the end of the critical period and was delayed by dark rearing. After CSPG degradation with chondroitinase-ABC in adult rats, monocular deprivation caused an ocular dominance shift toward the nondeprived eye. The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity.
@Article{Pizzorusso2002,
author = {Tommaso Pizzorusso and Paolo Medini and Nicoletta Berardi and Sabrina Chierzi and James W Fawcett and Lamberto Maffei},
journal = {Science},
title = {Reactivation of ocular dominance plasticity in the adult visual cortex.},
year = {2002},
number = {5596},
pages = {1248-51},
volume = {298},
abstract = {In young animals, monocular deprivation leads to an ocular dominance
shift, whereas in adults after the critical period there is no such
shift. Chondroitin sulphate proteoglycans (CSPGs) are components
of the extracellular matrix (ECM) inhibitory for axonal sprouting.
We tested whether the developmental maturation of the ECM is inhibitory
for experience-dependent plasticity in the visual cortex. The organization
of CSPGs into perineuronal nets coincided with the end of the critical
period and was delayed by dark rearing. After CSPG degradation with
chondroitinase-ABC in adult rats, monocular deprivation caused an
ocular dominance shift toward the nondeprived eye. The mature ECM
is thus inhibitory for experience-dependent plasticity, and degradation
of CSPGs reactivates cortical plasticity.},
doi = {10.1126/science.1072699},
keywords = {Acoustic Stimulation, Adaptation, Physiological, Aging, Animals, Auditory Pathways, Auditory Perception, Cues, Electrophysiology, Learning, Neuronal Plasticity, Owls, Space Perception, Superior Colliculus, Support, Non-U.S. Gov't, U.S. Gov't, Non-P.H.S., P.H.S., Time Factors, Visual Fields, Axons, Chondroitin ABC Lyase, Darkness, Dominance, Ocular, Extracellular Matrix, Extracellular Matrix Proteins, Glycosaminoglycans, Light, Nerve Tissue Proteins, Neurons, Proteochondroitin Sulfates, Rats, Synapses, Visual Acuity, Visual Cortex, 12424361},
}
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W","Maffei, L."],"bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["Tommaso"],"propositions":[],"lastnames":["Pizzorusso"],"suffixes":[]},{"firstnames":["Paolo"],"propositions":[],"lastnames":["Medini"],"suffixes":[]},{"firstnames":["Nicoletta"],"propositions":[],"lastnames":["Berardi"],"suffixes":[]},{"firstnames":["Sabrina"],"propositions":[],"lastnames":["Chierzi"],"suffixes":[]},{"firstnames":["James","W"],"propositions":[],"lastnames":["Fawcett"],"suffixes":[]},{"firstnames":["Lamberto"],"propositions":[],"lastnames":["Maffei"],"suffixes":[]}],"journal":"Science","title":"Reactivation of ocular dominance plasticity in the adult visual cortex.","year":"2002","number":"5596","pages":"1248-51","volume":"298","abstract":"In young animals, monocular deprivation leads to an ocular dominance shift, whereas in adults after the critical period there is no such shift. Chondroitin sulphate proteoglycans (CSPGs) are components of the extracellular matrix (ECM) inhibitory for axonal sprouting. We tested whether the developmental maturation of the ECM is inhibitory for experience-dependent plasticity in the visual cortex. The organization of CSPGs into perineuronal nets coincided with the end of the critical period and was delayed by dark rearing. After CSPG degradation with chondroitinase-ABC in adult rats, monocular deprivation caused an ocular dominance shift toward the nondeprived eye. 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Chondroitin sulphate proteoglycans (CSPGs) are components\n\tof the extracellular matrix (ECM) inhibitory for axonal sprouting.\n\tWe tested whether the developmental maturation of the ECM is inhibitory\n\tfor experience-dependent plasticity in the visual cortex. The organization\n\tof CSPGs into perineuronal nets coincided with the end of the critical\n\tperiod and was delayed by dark rearing. After CSPG degradation with\n\tchondroitinase-ABC in adult rats, monocular deprivation caused an\n\tocular dominance shift toward the nondeprived eye. 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