@Article{Pizzorusso2002,
  author   = {Tommaso Pizzorusso and Paolo Medini and Nicoletta Berardi and Sabrina Chierzi and James W Fawcett and Lamberto Maffei},
  journal  = {Science},
  title    = {Reactivation of ocular dominance plasticity in the adult visual cortex.},
  year     = {2002},
  number   = {5596},
  pages    = {1248-51},
  volume   = {298},
  abstract = {In young animals, monocular deprivation leads to an ocular dominance
	shift, whereas in adults after the critical period there is no such
	shift. Chondroitin sulphate proteoglycans (CSPGs) are components
	of the extracellular matrix (ECM) inhibitory for axonal sprouting.
	We tested whether the developmental maturation of the ECM is inhibitory
	for experience-dependent plasticity in the visual cortex. The organization
	of CSPGs into perineuronal nets coincided with the end of the critical
	period and was delayed by dark rearing. After CSPG degradation with
	chondroitinase-ABC in adult rats, monocular deprivation caused an
	ocular dominance shift toward the nondeprived eye. The mature ECM
	is thus inhibitory for experience-dependent plasticity, and degradation
	of CSPGs reactivates cortical plasticity.},
  doi      = {10.1126/science.1072699},
  keywords = {Acoustic Stimulation, Adaptation, Physiological, Aging, Animals, Auditory Pathways, Auditory Perception, Cues, Electrophysiology, Learning, Neuronal Plasticity, Owls, Space Perception, Superior Colliculus, Support, Non-U.S. Gov't, U.S. Gov't, Non-P.H.S., P.H.S., Time Factors, Visual Fields, Axons, Chondroitin ABC Lyase, Darkness, Dominance, Ocular, Extracellular Matrix, Extracellular Matrix Proteins, Glycosaminoglycans, Light, Nerve Tissue Proteins, Neurons, Proteochondroitin Sulfates, Rats, Synapses, Visual Acuity, Visual Cortex, 12424361},
}

{"_id":"nBHThHC8KMgtXnLuw","bibbaseid":"pizzorusso-medini-berardi-chierzi-fawcett-maffei-reactivationofoculardominanceplasticityintheadultvisualcortex-2002","author_short":["Pizzorusso, T.","Medini, P.","Berardi, N.","Chierzi, S.","Fawcett, J. W","Maffei, L."],"bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["Tommaso"],"propositions":[],"lastnames":["Pizzorusso"],"suffixes":[]},{"firstnames":["Paolo"],"propositions":[],"lastnames":["Medini"],"suffixes":[]},{"firstnames":["Nicoletta"],"propositions":[],"lastnames":["Berardi"],"suffixes":[]},{"firstnames":["Sabrina"],"propositions":[],"lastnames":["Chierzi"],"suffixes":[]},{"firstnames":["James","W"],"propositions":[],"lastnames":["Fawcett"],"suffixes":[]},{"firstnames":["Lamberto"],"propositions":[],"lastnames":["Maffei"],"suffixes":[]}],"journal":"Science","title":"Reactivation of ocular dominance plasticity in the adult visual cortex.","year":"2002","number":"5596","pages":"1248-51","volume":"298","abstract":"In young animals, monocular deprivation leads to an ocular dominance shift, whereas in adults after the critical period there is no such shift. Chondroitin sulphate proteoglycans (CSPGs) are components of the extracellular matrix (ECM) inhibitory for axonal sprouting. We tested whether the developmental maturation of the ECM is inhibitory for experience-dependent plasticity in the visual cortex. The organization of CSPGs into perineuronal nets coincided with the end of the critical period and was delayed by dark rearing. After CSPG degradation with chondroitinase-ABC in adult rats, monocular deprivation caused an ocular dominance shift toward the nondeprived eye. The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity.","doi":"10.1126/science.1072699","keywords":"Acoustic Stimulation, Adaptation, Physiological, Aging, Animals, Auditory Pathways, Auditory Perception, Cues, Electrophysiology, Learning, Neuronal Plasticity, Owls, Space Perception, Superior Colliculus, Support, Non-U.S. Gov't, U.S. Gov't, Non-P.H.S., P.H.S., Time Factors, Visual Fields, Axons, Chondroitin ABC Lyase, Darkness, Dominance, Ocular, Extracellular Matrix, Extracellular Matrix Proteins, Glycosaminoglycans, Light, Nerve Tissue Proteins, Neurons, Proteochondroitin Sulfates, Rats, Synapses, Visual Acuity, Visual Cortex, 12424361","bibtex":"@Article{Pizzorusso2002,\n author = {Tommaso Pizzorusso and Paolo Medini and Nicoletta Berardi and Sabrina Chierzi and James W Fawcett and Lamberto Maffei},\n journal = {Science},\n title = {Reactivation of ocular dominance plasticity in the adult visual cortex.},\n year = {2002},\n number = {5596},\n pages = {1248-51},\n volume = {298},\n abstract = {In young animals, monocular deprivation leads to an ocular dominance\n\tshift, whereas in adults after the critical period there is no such\n\tshift. Chondroitin sulphate proteoglycans (CSPGs) are components\n\tof the extracellular matrix (ECM) inhibitory for axonal sprouting.\n\tWe tested whether the developmental maturation of the ECM is inhibitory\n\tfor experience-dependent plasticity in the visual cortex. The organization\n\tof CSPGs into perineuronal nets coincided with the end of the critical\n\tperiod and was delayed by dark rearing. After CSPG degradation with\n\tchondroitinase-ABC in adult rats, monocular deprivation caused an\n\tocular dominance shift toward the nondeprived eye. The mature ECM\n\tis thus inhibitory for experience-dependent plasticity, and degradation\n\tof CSPGs reactivates cortical plasticity.},\n doi = {10.1126/science.1072699},\n keywords = {Acoustic Stimulation, Adaptation, Physiological, Aging, Animals, Auditory Pathways, Auditory Perception, Cues, Electrophysiology, Learning, Neuronal Plasticity, Owls, Space Perception, Superior Colliculus, Support, Non-U.S. Gov't, U.S. Gov't, Non-P.H.S., P.H.S., Time Factors, Visual Fields, Axons, Chondroitin ABC Lyase, Darkness, Dominance, Ocular, Extracellular Matrix, Extracellular Matrix Proteins, Glycosaminoglycans, Light, Nerve Tissue Proteins, Neurons, Proteochondroitin Sulfates, Rats, Synapses, Visual Acuity, Visual Cortex, 12424361},\n}\n\n","author_short":["Pizzorusso, T.","Medini, P.","Berardi, N.","Chierzi, S.","Fawcett, J. 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