@Article{Pizzorusso2006,
  author   = {Tommaso Pizzorusso and Paolo Medini and Silvia Landi and Sara Baldini and Nicoletta Berardi and Lamberto Maffei},
  journal  = {Proc Natl Acad Sci U S A},
  title    = {Structural and functional recovery from early monocular deprivation in adult rats.},
  year     = {2006},
  number   = {22},
  pages    = {8517-22},
  volume   = {103},
  abstract = {Visual deficits caused by abnormal visual experience during development
	are hard to recover in adult animals. Removal of chondroitin sulfate
	proteoglycans from the mature extracellular matrix with chondroitinase
	ABC promotes plasticity in the adult visual cortex. We tested whether
	chondroitinase ABC treatment of adult rats facilitates anatomical,
	functional, and behavioral recovery from the effects of a period
	of monocular deprivation initiated during the critical period for
	monocular deprivation. We found that chondroitinase ABC treatment
	coupled with reverse lid-suturing causes a complete recovery of ocular
	dominance, visual acuity, and dendritic spine density in adult rats.
	Thus, manipulations of the extracellular matrix can be used to promote
	functional recovery in the adult cortex.},
  doi      = {10.1073/pnas.0602657103},
  keywords = {16709670},
}

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