@article{
 title = {Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {*Family Characteristics,*Intergenerational Relations,Adult,European Continental Ancestry Group/*genetics,Female,Humans,Male,Pedigree,Reproduction/*genetics},
 pages = {165-169},
 volume = {81},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17564973},
 edition = {2007/06/15},
 id = {034af177-39d9-3139-9c4b-1e8a5d0cc7dd},
 created = {2017-06-19T13:44:22.139Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:22.316Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
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 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Pluzhnikov, Anna<m:linebreak/>Nolan, Daniel K<m:linebreak/>Tan, Zhiqiang<m:linebreak/>McPeek, Mary Sara<m:linebreak/>Ober, Carole<m:linebreak/>HD21244/HD/United States NICHD<m:linebreak/>HG1645/HG/United States NHGRI<m:linebreak/>Research Support, N.I.H., Extramural<m:linebreak/>United States<m:linebreak/>American journal of human genetics<m:linebreak/>Ajhg44597<m:linebreak/>Am J Hum Genet. 2007 Jul;81(1):165-9. Epub 2007 May 2.</m:note>},
 abstract = {Reproductive fitness is a complex phenotype that is a direct measure of Darwinian selection. Estimation of the genetic contribution to this phenotype in human populations is confounded by within-family correlations of sociocultural, economic, and other nongenetic factors that influence family sizes. Here, we report an intergenerational correlation in reproductive success in the Hutterites, a human population that is relatively homogeneous with respect to sociocultural factors that influence fertility. We introduce an estimator of this correlation that takes into account the presence of multiple parent-offspring pairs from the same nuclear family. Statistical significance of the estimated correlation is assessed by a permutation test that maintains the overall structure of the pedigree. Further, temporal trends in fertility within this population are accounted for. Applying these methods to the S-Leut Hutterites yields a correlation in effective family size of 0.29 between couples and their sons and 0.18 between couples and their daughters, with empirical P<1x10-6 and P=.0041, respectively. Similar results were obtained for completed families (0.31 between couples and their sons and 0.23 between couples and their daughters; empirical P<1x10-6 and P=.00059, respectively). We interpret these results as indicating a significant genetic component to reproductive fitness in the Hutterites.},
 bibtype = {article},
 author = {Pluzhnikov, A and Nolan, D K and Tan, Z and McPeek, M S and Ober, C},
 journal = {Am J Hum Genet},
 number = {1}
}

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