@ARTICLE{Pollen2015-mc,
  title    = "Molecular identity of human outer radial glia during cortical
              development",
  author   = "Pollen, Alex A and Nowakowski, Tomasz J and Chen, Jiadong and
              Retallack, Hanna and Sandoval-Espinosa, Carmen and Nicholas, Cory
              R and Shuga, Joe and Liu, Siyuan John and Oldham, Michael C and
              Diaz, Aaron and Lim, Daniel A and Leyrat, Anne A and West, Jay A
              and Kriegstein, Arnold R",
  abstract = "Radial glia, the neural stem cells of the neocortex, are located
              in two niches: the ventricular zone and outer subventricular
              zone. Although outer subventricular zone radial glia may generate
              the majority of human cortical neurons, their molecular features
              remain elusive. By analyzing gene expression across single cells,
              we find that outer radial glia preferentially express genes
              related to extracellular matrix formation, migration, and
              stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR. Using
              dynamic imaging, immunostaining, and clonal analysis, we relate
              these molecular features to distinctive behaviors of outer radial
              glia, demonstrate the necessity of STAT3 signaling for their cell
              cycle progression, and establish their extensive proliferative
              potential. These results suggest that outer radial glia directly
              support the subventricular niche through local production of
              growth factors, potentiation of growth factor signals by
              extracellular matrix proteins, and activation of self-renewal
              pathways, thereby enabling the developmental and evolutionary
              expansion of the human neocortex.",
  journal  = "Cell",
  volume   =  163,
  number   =  1,
  pages    = "55--67",
  month    =  sep,
  year     =  2015,
  language = "en"
}

{"_id":"7PESveyAHRdfyShML","bibbaseid":"pollen-nowakowski-chen-retallack-sandovalespinosa-nicholas-shuga-liu-etal-molecularidentityofhumanouterradialgliaduringcorticaldevelopment-2015","author_short":["Pollen, A. A","Nowakowski, T. J","Chen, J.","Retallack, H.","Sandoval-Espinosa, C.","Nicholas, C. R","Shuga, J.","Liu, S. J.","Oldham, M. C","Diaz, A.","Lim, D. A","Leyrat, A. A","West, J. A","Kriegstein, A. R"],"bibdata":{"bibtype":"article","type":"article","title":"Molecular identity of human outer radial glia during cortical development","author":[{"propositions":[],"lastnames":["Pollen"],"firstnames":["Alex","A"],"suffixes":[]},{"propositions":[],"lastnames":["Nowakowski"],"firstnames":["Tomasz","J"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Jiadong"],"suffixes":[]},{"propositions":[],"lastnames":["Retallack"],"firstnames":["Hanna"],"suffixes":[]},{"propositions":[],"lastnames":["Sandoval-Espinosa"],"firstnames":["Carmen"],"suffixes":[]},{"propositions":[],"lastnames":["Nicholas"],"firstnames":["Cory","R"],"suffixes":[]},{"propositions":[],"lastnames":["Shuga"],"firstnames":["Joe"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Siyuan","John"],"suffixes":[]},{"propositions":[],"lastnames":["Oldham"],"firstnames":["Michael","C"],"suffixes":[]},{"propositions":[],"lastnames":["Diaz"],"firstnames":["Aaron"],"suffixes":[]},{"propositions":[],"lastnames":["Lim"],"firstnames":["Daniel","A"],"suffixes":[]},{"propositions":[],"lastnames":["Leyrat"],"firstnames":["Anne","A"],"suffixes":[]},{"propositions":[],"lastnames":["West"],"firstnames":["Jay","A"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. Although outer subventricular zone radial glia may generate the majority of human cortical neurons, their molecular features remain elusive. By analyzing gene expression across single cells, we find that outer radial glia preferentially express genes related to extracellular matrix formation, migration, and stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR. Using dynamic imaging, immunostaining, and clonal analysis, we relate these molecular features to distinctive behaviors of outer radial glia, demonstrate the necessity of STAT3 signaling for their cell cycle progression, and establish their extensive proliferative potential. These results suggest that outer radial glia directly support the subventricular niche through local production of growth factors, potentiation of growth factor signals by extracellular matrix proteins, and activation of self-renewal pathways, thereby enabling the developmental and evolutionary expansion of the human neocortex.","journal":"Cell","volume":"163","number":"1","pages":"55–67","month":"September","year":"2015","language":"en","bibtex":"@ARTICLE{Pollen2015-mc,\n title = \"Molecular identity of human outer radial glia during cortical\n development\",\n author = \"Pollen, Alex A and Nowakowski, Tomasz J and Chen, Jiadong and\n Retallack, Hanna and Sandoval-Espinosa, Carmen and Nicholas, Cory\n R and Shuga, Joe and Liu, Siyuan John and Oldham, Michael C and\n Diaz, Aaron and Lim, Daniel A and Leyrat, Anne A and West, Jay A\n and Kriegstein, Arnold R\",\n abstract = \"Radial glia, the neural stem cells of the neocortex, are located\n in two niches: the ventricular zone and outer subventricular\n zone. Although outer subventricular zone radial glia may generate\n the majority of human cortical neurons, their molecular features\n remain elusive. By analyzing gene expression across single cells,\n we find that outer radial glia preferentially express genes\n related to extracellular matrix formation, migration, and\n stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR. Using\n dynamic imaging, immunostaining, and clonal analysis, we relate\n these molecular features to distinctive behaviors of outer radial\n glia, demonstrate the necessity of STAT3 signaling for their cell\n cycle progression, and establish their extensive proliferative\n potential. These results suggest that outer radial glia directly\n support the subventricular niche through local production of\n growth factors, potentiation of growth factor signals by\n extracellular matrix proteins, and activation of self-renewal\n pathways, thereby enabling the developmental and evolutionary\n expansion of the human neocortex.\",\n journal = \"Cell\",\n volume = 163,\n number = 1,\n pages = \"55--67\",\n month = sep,\n year = 2015,\n language = \"en\"\n}\n\n","author_short":["Pollen, A. A","Nowakowski, T. J","Chen, J.","Retallack, H.","Sandoval-Espinosa, C.","Nicholas, C. R","Shuga, J.","Liu, S. J.","Oldham, M. C","Diaz, A.","Lim, D. A","Leyrat, A. A","West, J. A","Kriegstein, A. R"],"key":"Pollen2015-mc","id":"Pollen2015-mc","bibbaseid":"pollen-nowakowski-chen-retallack-sandovalespinosa-nicholas-shuga-liu-etal-molecularidentityofhumanouterradialgliaduringcorticaldevelopment-2015","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["molecular","identity","human","outer","radial","glia","during","cortical","development","pollen","nowakowski","chen","retallack","sandoval-espinosa","nicholas","shuga","liu","oldham","diaz","lim","leyrat","west","kriegstein"],"title":"Molecular identity of human outer radial glia during cortical development","year":2015}