The protein quality control system manages plant defence compound synthesis. Pollier, J., Moses, T., González-Guzmán, M., De Geyter, N., Lippens, S., Vanden Bossche, R., Marhavý, P., Kremer, A., Morreel, K., Guérin, C. J., Tava, A., Oleszek, W., Thevelein, J. M., Campos, N., Goormachtig, S., & Goossens, A. Nature, 504(7478):148–152, December, 2013. doi abstract bibtex Jasmonates are ubiquitous oxylipin-derived phytohormones that are essential in the regulation of many development, growth and defence processes. Across the plant kingdom, jasmonates act as elicitors of the production of bioactive secondary metabolites that serve in defence against attackers. Knowledge of the conserved jasmonate perception and early signalling machineries is increasing, but the downstream mechanisms that regulate defence metabolism remain largely unknown. Here we show that, in the legume Medicago truncatula, jasmonate recruits the endoplasmic-reticulum-associated degradation (ERAD) quality control system to manage the production of triterpene saponins, widespread bioactive compounds that share a biogenic origin with sterols. An ERAD-type RING membrane-anchor E3 ubiquitin ligase is co-expressed with saponin synthesis enzymes to control the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the rate-limiting enzyme in the supply of the ubiquitous terpene precursor isopentenyl diphosphate. Thus, unrestrained bioactive saponin accumulation is prevented and plant development and integrity secured. This control apparatus is equivalent to the ERAD system that regulates sterol synthesis in yeasts and mammals but that uses distinct E3 ubiquitin ligases, of the HMGR degradation 1 (HRD1) type, to direct destruction of HMGR. Hence, the general principles for the management of sterol and triterpene saponin biosynthesis are conserved across eukaryotes but can be controlled by divergent regulatory cues.
@article{pollier_protein_2013,
title = {The protein quality control system manages plant defence compound synthesis},
volume = {504},
issn = {1476-4687},
doi = {10/f5jcsn},
abstract = {Jasmonates are ubiquitous oxylipin-derived phytohormones that are essential in the regulation of many development, growth and defence processes. Across the plant kingdom, jasmonates act as elicitors of the production of bioactive secondary metabolites that serve in defence against attackers. Knowledge of the conserved jasmonate perception and early signalling machineries is increasing, but the downstream mechanisms that regulate defence metabolism remain largely unknown. Here we show that, in the legume Medicago truncatula, jasmonate recruits the endoplasmic-reticulum-associated degradation (ERAD) quality control system to manage the production of triterpene saponins, widespread bioactive compounds that share a biogenic origin with sterols. An ERAD-type RING membrane-anchor E3 ubiquitin ligase is co-expressed with saponin synthesis enzymes to control the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the rate-limiting enzyme in the supply of the ubiquitous terpene precursor isopentenyl diphosphate. Thus, unrestrained bioactive saponin accumulation is prevented and plant development and integrity secured. This control apparatus is equivalent to the ERAD system that regulates sterol synthesis in yeasts and mammals but that uses distinct E3 ubiquitin ligases, of the HMGR degradation 1 (HRD1) type, to direct destruction of HMGR. Hence, the general principles for the management of sterol and triterpene saponin biosynthesis are conserved across eukaryotes but can be controlled by divergent regulatory cues.},
language = {eng},
number = {7478},
journal = {Nature},
author = {Pollier, Jacob and Moses, Tessa and González-Guzmán, Miguel and De Geyter, Nathan and Lippens, Saskia and Vanden Bossche, Robin and Marhavý, Peter and Kremer, Anna and Morreel, Kris and Guérin, Christopher J. and Tava, Aldo and Oleszek, Wieslaw and Thevelein, Johan M. and Campos, Narciso and Goormachtig, Sofie and Goossens, Alain},
month = dec,
year = {2013},
pmid = {24213631},
keywords = {Cells, Cultured, Endoplasmic Reticulum-Associated Degradation, Gene Expression Profiling, Gene Expression Regulation, Plant, Gene Silencing, Genetic Complementation Test, Medicago truncatula, Microscopy, Electron, Scanning, Molecular Sequence Data, Mutation, Plant Growth Regulators, Plant Roots, Saccharomyces cerevisiae, Saponins, Signal Transduction, Ubiquitin-Protein Ligases},
pages = {148--152},
}
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Knowledge of the conserved jasmonate perception and early signalling machineries is increasing, but the downstream mechanisms that regulate defence metabolism remain largely unknown. Here we show that, in the legume Medicago truncatula, jasmonate recruits the endoplasmic-reticulum-associated degradation (ERAD) quality control system to manage the production of triterpene saponins, widespread bioactive compounds that share a biogenic origin with sterols. An ERAD-type RING membrane-anchor E3 ubiquitin ligase is co-expressed with saponin synthesis enzymes to control the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the rate-limiting enzyme in the supply of the ubiquitous terpene precursor isopentenyl diphosphate. Thus, unrestrained bioactive saponin accumulation is prevented and plant development and integrity secured. This control apparatus is equivalent to the ERAD system that regulates sterol synthesis in yeasts and mammals but that uses distinct E3 ubiquitin ligases, of the HMGR degradation 1 (HRD1) type, to direct destruction of HMGR. Hence, the general principles for the management of sterol and triterpene saponin biosynthesis are conserved across eukaryotes but can be controlled by divergent regulatory cues.","language":"eng","number":"7478","journal":"Nature","author":[{"propositions":[],"lastnames":["Pollier"],"firstnames":["Jacob"],"suffixes":[]},{"propositions":[],"lastnames":["Moses"],"firstnames":["Tessa"],"suffixes":[]},{"propositions":[],"lastnames":["González-Guzmán"],"firstnames":["Miguel"],"suffixes":[]},{"propositions":[],"lastnames":["De","Geyter"],"firstnames":["Nathan"],"suffixes":[]},{"propositions":[],"lastnames":["Lippens"],"firstnames":["Saskia"],"suffixes":[]},{"propositions":[],"lastnames":["Vanden","Bossche"],"firstnames":["Robin"],"suffixes":[]},{"propositions":[],"lastnames":["Marhavý"],"firstnames":["Peter"],"suffixes":[]},{"propositions":[],"lastnames":["Kremer"],"firstnames":["Anna"],"suffixes":[]},{"propositions":[],"lastnames":["Morreel"],"firstnames":["Kris"],"suffixes":[]},{"propositions":[],"lastnames":["Guérin"],"firstnames":["Christopher","J."],"suffixes":[]},{"propositions":[],"lastnames":["Tava"],"firstnames":["Aldo"],"suffixes":[]},{"propositions":[],"lastnames":["Oleszek"],"firstnames":["Wieslaw"],"suffixes":[]},{"propositions":[],"lastnames":["Thevelein"],"firstnames":["Johan","M."],"suffixes":[]},{"propositions":[],"lastnames":["Campos"],"firstnames":["Narciso"],"suffixes":[]},{"propositions":[],"lastnames":["Goormachtig"],"firstnames":["Sofie"],"suffixes":[]},{"propositions":[],"lastnames":["Goossens"],"firstnames":["Alain"],"suffixes":[]}],"month":"December","year":"2013","pmid":"24213631","keywords":"Cells, Cultured, Endoplasmic Reticulum-Associated Degradation, Gene Expression Profiling, Gene Expression Regulation, Plant, Gene Silencing, Genetic Complementation Test, Medicago truncatula, Microscopy, Electron, Scanning, Molecular Sequence Data, Mutation, Plant Growth Regulators, Plant Roots, Saccharomyces cerevisiae, Saponins, Signal Transduction, Ubiquitin-Protein Ligases","pages":"148–152","bibtex":"@article{pollier_protein_2013,\n\ttitle = {The protein quality control system manages plant defence compound synthesis},\n\tvolume = {504},\n\tissn = {1476-4687},\n\tdoi = {10/f5jcsn},\n\tabstract = {Jasmonates are ubiquitous oxylipin-derived phytohormones that are essential in the regulation of many development, growth and defence processes. 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