A mild biosynthesis of lactones via enantioselective hydrolysis of hydroxynitriles. Pollock, J. A., Clark, K. M., Martynowicz, B. J., Pridgeon, M. G., Rycenga, M. J., Stolle, K. E., & Taylor, S. K. Tetrahedron-Asymmetry, 18(16):1888--1892, August, 2007. WOS:000250248000002
doi  abstract   bibtex   
We have developed a biocatalytic method to produce lactones and related compounds via the enzymatic hydrolysis of gamma- and beta-hydroxynitriles. The synthesis is a mild, general, and environmentally friendly way to enantioselectively hydrolyze nitriles with commercially available nitrilase enzymes. The synthesis of four pheromones is demonstrated via a one-step method. (c) 2007 Elsevier Ltd. All rights reserved.
@article{ pollock_mild_2007,
  title = {A mild biosynthesis of lactones via enantioselective hydrolysis of hydroxynitriles},
  volume = {18},
  doi = {10.1016/i.tetasv.2007.07.034},
  abstract = {We have developed a biocatalytic method to produce lactones and related compounds via the enzymatic hydrolysis of gamma- and beta-hydroxynitriles. The synthesis is a mild, general, and environmentally friendly way to enantioselectively hydrolyze nitriles with commercially available nitrilase enzymes. The synthesis of four pheromones is demonstrated via a one-step method. (c) 2007 Elsevier Ltd. All rights reserved.},
  number = {16},
  journal = {Tetrahedron-Asymmetry},
  author = {Pollock, Julie A. and Clark, Karen M. and Martynowicz, Bethany J. and Pridgeon, Matthew G. and Rycenga, Matthew J. and Stolle, Kristen E. and Taylor, Stephen K.},
  month = {August},
  year = {2007},
  note = {{WOS}:000250248000002},
  pages = {1888--1892}
}

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