Heterogeneity of a Campylobacter jejuni Protein That Is Secreted through the Flagellar Filament. Poly, F., Ewing, C., Goon, S., Hickey, T. E., Rockabrand, D., Majam, G., Lee, L., Phan, J., Savarino, N. J., & Guerry, P. Infection and Immunity, 75(8):3859--3867, August, 2007.
Paper doi abstract bibtex Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a σ28 promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.
@article{poly_heterogeneity_2007,
title = {Heterogeneity of a {Campylobacter} jejuni {Protein} {That} {Is} {Secreted} through the {Flagellar} {Filament}},
volume = {75},
issn = {0019-9567, 1098-5522},
url = {http://iai.asm.org/content/75/8/3859},
doi = {10.1128/IAI.00159-07},
abstract = {Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a σ28 promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.},
language = {en},
number = {8},
urldate = {2015-01-11TZ},
journal = {Infection and Immunity},
author = {Poly, Frédéric and Ewing, Cheryl and Goon, Scarlett and Hickey, Thomas E. and Rockabrand, David and Majam, Gary and Lee, Lanfong and Phan, Julie and Savarino, Nicholas J. and Guerry, Patricia},
month = aug,
year = {2007},
pmid = {17517862},
pages = {3859--3867}
}
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