@article{
 title = {Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy},
 type = {article},
 year = {2004},
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 keywords = {*Genetic Variation,Adolescent,Adult,Age Distribution,Asthma/diagnosis/epidemiology/*genetics,Case-Control Studies,Child,Child, Preschool,Female,Genetic Predisposition to Disease/*epidemiology,Genotype,Humans,Hypersensitivity/diagnosis/epidemiology/*genetics,Male,Middle Aged,Pedigree,Prevalence,Quebec/epidemiology,Receptors, Calcitriol/*genetics,Sex Distribution},
 pages = {967-973},
 volume = {170},
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 edition = {2004/07/30},
 id = {6e965c30-7f78-396b-93e3-17c181d1d6c5},
 created = {2017-06-19T13:45:42.665Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
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 notes = {<m:note>Poon, Audrey H<m:linebreak/>Laprise, Catherine<m:linebreak/>Lemire, Mathieu<m:linebreak/>Montpetit, Alexandre<m:linebreak/>Sinnett, Donna<m:linebreak/>Schurr, Erwin<m:linebreak/>Hudson, Thomas J<m:linebreak/>Comparative Study<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>United States<m:linebreak/>American journal of respiratory and critical care medicine<m:linebreak/>200403-412oc<m:linebreak/>Am J Respir Crit Care Med. 2004 Nov 1;170(9):967-73. Epub 2004 Jul 28.</m:note>},
 abstract = {Genome scans for asthma have identified suggestive or significant linkages on 17 different chromosomes, including chromosome 12, region q13-23, housing the vitamin D receptor (VDR) gene. Through interaction with VDR, 1,25-dihydroxyvitamin D3 mediates numerous biological activities, such as regulation of helper T-cell development and subsequent cytokine secretion profiles. Variants of the VDR have been found to be associated with immune-mediated diseases that are characterized by an imbalance in helper T-cell development, such as Crohn's disease and tuberculosis. The VDR, hence, is a good candidate to be investigated for association with asthma, which is characterized by enhanced helper T-cell type 2 activity. Here, we examined VDR genetic variants in an asthma family-based cohort from Quebec. We report six variants to be strongly associated with asthma and four with atopy (0.0005 < or = p < or = 0.05). Analysis of the linkage disequilibrium pattern and haplotypes also revealed significant association with both phenotypes (0.0004 < or = p < or = 0.01). The findings have been replicated by another research team in a second but not in a third cohort. These results identify VDR variants as genetic risk factors for asthma/atopy and implicate a non-human leukocyte antigen immunoregulatory molecule in the pathogenesis of asthma and atopy.},
 bibtype = {article},
 author = {Poon, A H and Laprise, C and Lemire, M and Montpetit, A and Sinnett, D and Schurr, E and Hudson, T J},
 journal = {Am J Respir Crit Care Med},
 number = {9}
}

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Epub 2004 Jul 28.</m:note>","abstract":"Genome scans for asthma have identified suggestive or significant linkages on 17 different chromosomes, including chromosome 12, region q13-23, housing the vitamin D receptor (VDR) gene. Through interaction with VDR, 1,25-dihydroxyvitamin D3 mediates numerous biological activities, such as regulation of helper T-cell development and subsequent cytokine secretion profiles. Variants of the VDR have been found to be associated with immune-mediated diseases that are characterized by an imbalance in helper T-cell development, such as Crohn's disease and tuberculosis. The VDR, hence, is a good candidate to be investigated for association with asthma, which is characterized by enhanced helper T-cell type 2 activity. Here, we examined VDR genetic variants in an asthma family-based cohort from Quebec. We report six variants to be strongly associated with asthma and four with atopy (0.0005 < or = p < or = 0.05). Analysis of the linkage disequilibrium pattern and haplotypes also revealed significant association with both phenotypes (0.0004 < or = p < or = 0.01). The findings have been replicated by another research team in a second but not in a third cohort. These results identify VDR variants as genetic risk factors for asthma/atopy and implicate a non-human leukocyte antigen immunoregulatory molecule in the pathogenesis of asthma and atopy.","bibtype":"article","author":"Poon, A H and Laprise, C and Lemire, M and Montpetit, A and Sinnett, D and Schurr, E and Hudson, T J","journal":"Am J Respir Crit Care Med","number":"9","bibtex":"@article{\n title = {Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy},\n type = {article},\n year = {2004},\n identifiers = {[object Object]},\n keywords = {*Genetic Variation,Adolescent,Adult,Age Distribution,Asthma/diagnosis/epidemiology/*genetics,Case-Control Studies,Child,Child, Preschool,Female,Genetic Predisposition to Disease/*epidemiology,Genotype,Humans,Hypersensitivity/diagnosis/epidemiology/*genetics,Male,Middle Aged,Pedigree,Prevalence,Quebec/epidemiology,Receptors, Calcitriol/*genetics,Sex Distribution},\n pages = {967-973},\n volume = {170},\n websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15282199},\n edition = {2004/07/30},\n id = {6e965c30-7f78-396b-93e3-17c181d1d6c5},\n created = {2017-06-19T13:45:42.665Z},\n file_attached = {true},\n profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},\n group_id = {b2078731-0913-33b9-8902-a53629a24e83},\n last_modified = {2017-06-19T13:45:42.821Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n source_type = {Journal Article},\n language = {eng},\n notes = {<m:note>Poon, Audrey H<m:linebreak/>Laprise, Catherine<m:linebreak/>Lemire, Mathieu<m:linebreak/>Montpetit, Alexandre<m:linebreak/>Sinnett, Donna<m:linebreak/>Schurr, Erwin<m:linebreak/>Hudson, Thomas J<m:linebreak/>Comparative Study<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>United States<m:linebreak/>American journal of respiratory and critical care medicine<m:linebreak/>200403-412oc<m:linebreak/>Am J Respir Crit Care Med. 2004 Nov 1;170(9):967-73. 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