@article{porta_morbidity_2017,
	title = {Morbidity and mortality of very low birth weight multiples compared with singletons},
	issn = {1476-4954},
	doi = {10.1080/14767058.2017.1379073},
	abstract = {BACKGROUND: Previous studies comparing the neonatal outcome of very low birth weight (VLBW) multiples and singletons have suggested a worse outcome for multiples at gestational ages on the limits of viability.
OBJECTIVES: The objective of this study is to determine the neonatal mortality and morbidity of VLBW multiples compared to singletons.
METHODS: This is a retrospective study including all infants registered in the Spanish network for infants under 1500 g (SEN1500), over a 12-year period (from 2002 to 2013). Mortality and major morbidities were compared between singletons and multiples.
RESULTS: About 32,770 infants were included: 21,123 singletons (64.5\%) and 11,647 multiples (35.5\%), with a mean gestational age of 29.5 weeks (22-38), and mean birth weight of 1115 g (340-1500). When adjusted by other perinatal factors, multiple pregnancy has a significantly higher risk of mortality than singleton pregnancy (odds ratio (OR) 1.15; IC 95\% 1.05-1.26, p = .002), but not a higher risk of major morbidity or composite adverse outcome. In the subgroup of infants born before 26 weeks, multiples showed a higher risk of mortality (63.9\% versus 51\%, OR 1.7; 95\% CI 1.47-1.96) and a higher risk of composite adverse outcome (88.9\% versus 81.5\%, OR 1.82, 95\% CI 1.28-2.24).
CONCLUSIONS: In preterm infants born with less than 1500 g, multiple pregnancy is a prognostic factor that can slightly increase mortality. Extremely preterm infants born before 26 weeks have a greater risk of mortality and major morbidity if they come from a multiple pregnancy.},
	language = {eng},
	journal = {Journal of Maternal-Fetal \& Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},
	author = {Porta, Roser and Capdevila, Eva and Botet, Francesc and Verd, Sergi and Ginovart, Gemma and Moliner, Elisenda and Nicolàs, Marta and Rios, Jose and {SEN1500 Network}},
	year = {2017},
	pmid = {28936899},
	keywords = {Article, Mortality, Pediatria, multiples, singletons},
	pages = {1--9},
}

{"_id":"3shKjMgp3AJFbvwrf","bibbaseid":"porta-capdevila-botet-verd-ginovart-moliner-nicols-rios-etal-morbidityandmortalityofverylowbirthweightmultiplescomparedwithsingletons-2017","downloads":0,"creationDate":"2018-10-11T03:50:31.416Z","title":"Morbidity and mortality of very low birth weight multiples compared with singletons","author_short":["Porta, R.","Capdevila, E.","Botet, F.","Verd, S.","Ginovart, G.","Moliner, E.","Nicolàs, M.","Rios, J.","SEN1500 Network"],"year":2017,"bibtype":"article","biburl":"https://bibbase.org/zotero/Bibliotecacst","bibdata":{"bibtype":"article","type":"article","title":"Morbidity and mortality of very low birth weight multiples compared with singletons","issn":"1476-4954","doi":"10.1080/14767058.2017.1379073","abstract":"BACKGROUND: Previous studies comparing the neonatal outcome of very low birth weight (VLBW) multiples and singletons have suggested a worse outcome for multiples at gestational ages on the limits of viability. OBJECTIVES: The objective of this study is to determine the neonatal mortality and morbidity of VLBW multiples compared to singletons. METHODS: This is a retrospective study including all infants registered in the Spanish network for infants under 1500 g (SEN1500), over a 12-year period (from 2002 to 2013). Mortality and major morbidities were compared between singletons and multiples. RESULTS: About 32,770 infants were included: 21,123 singletons (64.5%) and 11,647 multiples (35.5%), with a mean gestational age of 29.5 weeks (22-38), and mean birth weight of 1115 g (340-1500). When adjusted by other perinatal factors, multiple pregnancy has a significantly higher risk of mortality than singleton pregnancy (odds ratio (OR) 1.15; IC 95% 1.05-1.26, p = .002), but not a higher risk of major morbidity or composite adverse outcome. In the subgroup of infants born before 26 weeks, multiples showed a higher risk of mortality (63.9% versus 51%, OR 1.7; 95% CI 1.47-1.96) and a higher risk of composite adverse outcome (88.9% versus 81.5%, OR 1.82, 95% CI 1.28-2.24). CONCLUSIONS: In preterm infants born with less than 1500 g, multiple pregnancy is a prognostic factor that can slightly increase mortality. Extremely preterm infants born before 26 weeks have a greater risk of mortality and major morbidity if they come from a multiple pregnancy.","language":"eng","journal":"Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","author":[{"propositions":[],"lastnames":["Porta"],"firstnames":["Roser"],"suffixes":[]},{"propositions":[],"lastnames":["Capdevila"],"firstnames":["Eva"],"suffixes":[]},{"propositions":[],"lastnames":["Botet"],"firstnames":["Francesc"],"suffixes":[]},{"propositions":[],"lastnames":["Verd"],"firstnames":["Sergi"],"suffixes":[]},{"propositions":[],"lastnames":["Ginovart"],"firstnames":["Gemma"],"suffixes":[]},{"propositions":[],"lastnames":["Moliner"],"firstnames":["Elisenda"],"suffixes":[]},{"propositions":[],"lastnames":["Nicolàs"],"firstnames":["Marta"],"suffixes":[]},{"propositions":[],"lastnames":["Rios"],"firstnames":["Jose"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["SEN1500 Network"],"suffixes":[]}],"year":"2017","pmid":"28936899","keywords":"Article, Mortality, Pediatria, multiples, singletons","pages":"1–9","bibtex":"@article{porta_morbidity_2017,\n\ttitle = {Morbidity and mortality of very low birth weight multiples compared with singletons},\n\tissn = {1476-4954},\n\tdoi = {10.1080/14767058.2017.1379073},\n\tabstract = {BACKGROUND: Previous studies comparing the neonatal outcome of very low birth weight (VLBW) multiples and singletons have suggested a worse outcome for multiples at gestational ages on the limits of viability.\nOBJECTIVES: The objective of this study is to determine the neonatal mortality and morbidity of VLBW multiples compared to singletons.\nMETHODS: This is a retrospective study including all infants registered in the Spanish network for infants under 1500 g (SEN1500), over a 12-year period (from 2002 to 2013). Mortality and major morbidities were compared between singletons and multiples.\nRESULTS: About 32,770 infants were included: 21,123 singletons (64.5\\%) and 11,647 multiples (35.5\\%), with a mean gestational age of 29.5 weeks (22-38), and mean birth weight of 1115 g (340-1500). When adjusted by other perinatal factors, multiple pregnancy has a significantly higher risk of mortality than singleton pregnancy (odds ratio (OR) 1.15; IC 95\\% 1.05-1.26, p = .002), but not a higher risk of major morbidity or composite adverse outcome. In the subgroup of infants born before 26 weeks, multiples showed a higher risk of mortality (63.9\\% versus 51\\%, OR 1.7; 95\\% CI 1.47-1.96) and a higher risk of composite adverse outcome (88.9\\% versus 81.5\\%, OR 1.82, 95\\% CI 1.28-2.24).\nCONCLUSIONS: In preterm infants born with less than 1500 g, multiple pregnancy is a prognostic factor that can slightly increase mortality. Extremely preterm infants born before 26 weeks have a greater risk of mortality and major morbidity if they come from a multiple pregnancy.},\n\tlanguage = {eng},\n\tjournal = {Journal of Maternal-Fetal \\& Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},\n\tauthor = {Porta, Roser and Capdevila, Eva and Botet, Francesc and Verd, Sergi and Ginovart, Gemma and Moliner, Elisenda and Nicolàs, Marta and Rios, Jose and {SEN1500 Network}},\n\tyear = {2017},\n\tpmid = {28936899},\n\tkeywords = {Article, Mortality, Pediatria, multiples, singletons},\n\tpages = {1--9},\n}\n\n","author_short":["Porta, R.","Capdevila, E.","Botet, F.","Verd, S.","Ginovart, G.","Moliner, E.","Nicolàs, M.","Rios, J.","SEN1500 Network"],"key":"porta_morbidity_2017","id":"porta_morbidity_2017","bibbaseid":"porta-capdevila-botet-verd-ginovart-moliner-nicols-rios-etal-morbidityandmortalityofverylowbirthweightmultiplescomparedwithsingletons-2017","role":"author","urls":{},"keyword":["Article","Mortality","Pediatria","multiples","singletons"],"downloads":0,"html":"","metadata":{"authorlinks":{}}},"search_terms":["morbidity","mortality","very","low","birth","weight","multiples","compared","singletons","porta","capdevila","botet","verd","ginovart","moliner","nicolàs","rios","sen1500 network"],"keywords":["article","mortality","pediatria","multiples","singletons"],"authorIDs":[],"dataSources":["TR9pX4mH5rDPr29Zo"]}