Protein expression of MMP-2 and MT1-MMP in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma. Poswar, F., D., O., Fraga, C., A., D., C., Gomes, E., S., B., Farias, L., C., Souza, L., W., F., Santos, S., H., S., Gomez, R., S., Batista De-Paula, A., M., & Guimarães, A., L., S. International Journal of Surgical Pathology, 23(1):20-25, 2015. doi abstract bibtex Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P <.05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.
@article{
title = {Protein expression of MMP-2 and MT1-MMP in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma},
type = {article},
year = {2015},
keywords = {Actinic keratosis,Basal cell carcinoma,Matrix metalloproteinase-2,Membrane-type matrix metalloproteinase-1,Squamous cell carcinoma},
pages = {20-25},
volume = {23},
id = {63845991-be7a-3f75-9e2a-4d0bcbb1d361},
created = {2018-01-16T17:29:08.084Z},
file_attached = {false},
profile_id = {a1b2ded6-b257-3e56-ac7c-9d438762d170},
last_modified = {2021-10-19T17:32:16.059Z},
read = {false},
starred = {false},
authored = {true},
confirmed = {true},
hidden = {false},
private_publication = {false},
abstract = {Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P <.05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.},
bibtype = {article},
author = {Poswar, Fabiano De Oliveira and Fraga, Carlos Alberto De Carvalho and Gomes, Emisael Stênio Batista and Farias, Lucyana Conceic¸ão and Souza, Linton Wallis Figueiredo and Santos, Sérgio Henrique Souza and Gomez, Ricardo Santiago and Batista De-Paula, Alfredo Maurício and Guimarães, André Luiz Sena},
doi = {10.1177/1066896914540998},
journal = {International Journal of Surgical Pathology},
number = {1}
}
Downloads: 0
{"_id":"7tqQoCfzQgCLEcePz","bibbaseid":"poswar-fraga-gomes-farias-souza-santos-gomez-batistadepaula-etal-proteinexpressionofmmp2andmt1mmpinactinickeratosissquamouscellcarcinomaoftheskinandbasalcellcarcinoma-2015","authorIDs":[],"author_short":["Poswar, F., D., O.","Fraga, C., A., D., C.","Gomes, E., S., B.","Farias, L., C.","Souza, L., W., F.","Santos, S., H., S.","Gomez, R., S.","Batista De-Paula, A., M.","Guimarães, A., L., S."],"bibdata":{"title":"Protein expression of MMP-2 and MT1-MMP in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma","type":"article","year":"2015","keywords":"Actinic keratosis,Basal cell carcinoma,Matrix metalloproteinase-2,Membrane-type matrix metalloproteinase-1,Squamous cell carcinoma","pages":"20-25","volume":"23","id":"63845991-be7a-3f75-9e2a-4d0bcbb1d361","created":"2018-01-16T17:29:08.084Z","file_attached":false,"profile_id":"a1b2ded6-b257-3e56-ac7c-9d438762d170","last_modified":"2021-10-19T17:32:16.059Z","read":false,"starred":false,"authored":"true","confirmed":"true","hidden":false,"private_publication":false,"abstract":"Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P <.05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.","bibtype":"article","author":"Poswar, Fabiano De Oliveira and Fraga, Carlos Alberto De Carvalho and Gomes, Emisael Stênio Batista and Farias, Lucyana Conceic¸ão and Souza, Linton Wallis Figueiredo and Santos, Sérgio Henrique Souza and Gomez, Ricardo Santiago and Batista De-Paula, Alfredo Maurício and Guimarães, André Luiz Sena","doi":"10.1177/1066896914540998","journal":"International Journal of Surgical Pathology","number":"1","bibtex":"@article{\n title = {Protein expression of MMP-2 and MT1-MMP in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma},\n type = {article},\n year = {2015},\n keywords = {Actinic keratosis,Basal cell carcinoma,Matrix metalloproteinase-2,Membrane-type matrix metalloproteinase-1,Squamous cell carcinoma},\n pages = {20-25},\n volume = {23},\n id = {63845991-be7a-3f75-9e2a-4d0bcbb1d361},\n created = {2018-01-16T17:29:08.084Z},\n file_attached = {false},\n profile_id = {a1b2ded6-b257-3e56-ac7c-9d438762d170},\n last_modified = {2021-10-19T17:32:16.059Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n private_publication = {false},\n abstract = {Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are 2 skin neoplasms with distinct potentials to invasion and metastasis. Actinic keratosis (AK) is a precursor lesion of SCC. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MT1-MMP in samples of BCC (n = 29), SCC (n = 12), and AK (n = 13). The ratio of positive cells to total cells was used to quantify the staining. Statistical significance was considered under the level P <.05. We found a higher expression of MMP-2 in tumor stroma and parenchyma of SCC as compared to BCC. The expression of this protein was also similar between SCC and its precursor actinic keratosis, and it was higher in the stroma of high-risk BCC when compared to low-risk BCC. MT1-MMP, which is an activator of MMP-2, was similarly expressed in all groups. Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in SCC and BCC.},\n bibtype = {article},\n author = {Poswar, Fabiano De Oliveira and Fraga, Carlos Alberto De Carvalho and Gomes, Emisael Stênio Batista and Farias, Lucyana Conceic¸ão and Souza, Linton Wallis Figueiredo and Santos, Sérgio Henrique Souza and Gomez, Ricardo Santiago and Batista De-Paula, Alfredo Maurício and Guimarães, André Luiz Sena},\n doi = {10.1177/1066896914540998},\n journal = {International Journal of Surgical Pathology},\n number = {1}\n}","author_short":["Poswar, F., D., O.","Fraga, C., A., D., C.","Gomes, E., S., B.","Farias, L., C.","Souza, L., W., F.","Santos, S., H., S.","Gomez, R., S.","Batista De-Paula, A., M.","Guimarães, A., L., S."],"biburl":"https://bibbase.org/service/mendeley/a1b2ded6-b257-3e56-ac7c-9d438762d170","bibbaseid":"poswar-fraga-gomes-farias-souza-santos-gomez-batistadepaula-etal-proteinexpressionofmmp2andmt1mmpinactinickeratosissquamouscellcarcinomaoftheskinandbasalcellcarcinoma-2015","role":"author","urls":{},"keyword":["Actinic keratosis","Basal cell carcinoma","Matrix metalloproteinase-2","Membrane-type matrix metalloproteinase-1","Squamous cell carcinoma"],"metadata":{"authorlinks":{}},"downloads":0},"bibtype":"article","creationDate":"2020-02-05T21:53:19.727Z","downloads":0,"keywords":["actinic keratosis","basal cell carcinoma","matrix metalloproteinase-2","membrane-type matrix metalloproteinase-1","squamous cell carcinoma"],"search_terms":["protein","expression","mmp","mt1","mmp","actinic","keratosis","squamous","cell","carcinoma","skin","basal","cell","carcinoma","poswar","fraga","gomes","farias","souza","santos","gomez","batista de-paula","guimarães"],"title":"Protein expression of MMP-2 and MT1-MMP in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma","year":2015,"biburl":"https://bibbase.org/service/mendeley/a1b2ded6-b257-3e56-ac7c-9d438762d170","dataSources":["KeLrgK49soyCLiQgv","ya2CyA73rpZseyrZ8","2252seNhipfTmjEBQ"]}