Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress. Pothion, S., Bizot, J.C., Trovero, F., & Belzung, C. Behavioural Brain Research, 155(1):135--146, November, 2004. doi abstract bibtex Effects of unpredictable chronic mild stress (UCMS) on anhedonic-like behaviour, physical state, body weight, learning and memory were investigated in three strains of mice. These strains were chosen among 11 strains that were tested in a first experiment for their sucrose consumption and preference for sucrose solutions of different concentrations. In the second experiment, groups of mice of the CBA/H, C57BL/6 and DBA/2 strains were submitted to 7 weeks of UCMS. Measures of the sucrose consumption, the evaluation of the physical state and the measurement of body weight were weekly assessed. Following 4-week period of UCMS, sub-groups of stressed and non-stressed mice were submitted to the spontaneous alternation test in the Y-maze, and then to the water-maze test for spatial learning and memory. UCMS induced a significant decrease of the sucrose consumption in CBA/H and in C57BL/6 but not in DBA/2 mice. The UCMS effect on sucrose intake in CBA/H mice was associated with a body weight loss and a physical state degradation. Spatial learning in a water maze was not disturbed by UCMS, however, a long-term memory impairment was observed in CBA/H stressed mice during a probe test. In the Y-maze, UCMS did not modify spontaneous alternation. These results show both an anhedonic-like and an amnesic effect of UCMS in CBA/H mice. They also reveal a difference of sensitivity to UCMS according to the strain of mice.
@article{ pothion_strain_2004,
title = {Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress},
volume = {155},
issn = {0166-4328},
doi = {10.1016/j.bbr.2004.04.008},
abstract = {Effects of unpredictable chronic mild stress ({UCMS}) on anhedonic-like behaviour, physical state, body weight, learning and memory were investigated in three strains of mice. These strains were chosen among 11 strains that were tested in a first experiment for their sucrose consumption and preference for sucrose solutions of different concentrations. In the second experiment, groups of mice of the {CBA}/H, C57BL/6 and {DBA}/2 strains were submitted to 7 weeks of {UCMS}. Measures of the sucrose consumption, the evaluation of the physical state and the measurement of body weight were weekly assessed. Following 4-week period of {UCMS}, sub-groups of stressed and non-stressed mice were submitted to the spontaneous alternation test in the Y-maze, and then to the water-maze test for spatial learning and memory. {UCMS} induced a significant decrease of the sucrose consumption in {CBA}/H and in C57BL/6 but not in {DBA}/2 mice. The {UCMS} effect on sucrose intake in {CBA}/H mice was associated with a body weight loss and a physical state degradation. Spatial learning in a water maze was not disturbed by {UCMS}, however, a long-term memory impairment was observed in {CBA}/H stressed mice during a probe test. In the Y-maze, {UCMS} did not modify spontaneous alternation. These results show both an anhedonic-like and an amnesic effect of {UCMS} in {CBA}/H mice. They also reveal a difference of sensitivity to {UCMS} according to the strain of mice.},
language = {eng},
number = {1},
journal = {Behavioural Brain Research},
author = {Pothion, Stéphanie and Bizot, Jean-Charles and Trovero, Fabrice and Belzung, Catherine},
month = {November},
year = {2004},
pmid = {15325787},
keywords = {Analysis of Variance, Animals, Behavior, Animal, Chi-Square Distribution, Chronic Disease, Conditioning, Operant, Dose-Response Relationship, Drug, Drinking Behavior, Exploratory Behavior, Male, Maze Learning, Mice, Mice, Inbred C57BL, Mice, Inbred {CBA}, Mice, Inbred {DBA}, Mice, Inbred Strains, Species Specificity, Stress, Psychological, Sucrose, Time Factors},
pages = {135--146}
}
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Following 4-week period of UCMS, sub-groups of stressed and non-stressed mice were submitted to the spontaneous alternation test in the Y-maze, and then to the water-maze test for spatial learning and memory. UCMS induced a significant decrease of the sucrose consumption in CBA/H and in C57BL/6 but not in DBA/2 mice. The UCMS effect on sucrose intake in CBA/H mice was associated with a body weight loss and a physical state degradation. Spatial learning in a water maze was not disturbed by UCMS, however, a long-term memory impairment was observed in CBA/H stressed mice during a probe test. In the Y-maze, UCMS did not modify spontaneous alternation. These results show both an anhedonic-like and an amnesic effect of UCMS in CBA/H mice. 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Measures of the sucrose consumption, the evaluation of the physical state and the measurement of body weight were weekly assessed. Following 4-week period of {UCMS}, sub-groups of stressed and non-stressed mice were submitted to the spontaneous alternation test in the Y-maze, and then to the water-maze test for spatial learning and memory. {UCMS} induced a significant decrease of the sucrose consumption in {CBA}/H and in C57BL/6 but not in {DBA}/2 mice. The {UCMS} effect on sucrose intake in {CBA}/H mice was associated with a body weight loss and a physical state degradation. Spatial learning in a water maze was not disturbed by {UCMS}, however, a long-term memory impairment was observed in {CBA}/H stressed mice during a probe test. In the Y-maze, {UCMS} did not modify spontaneous alternation. These results show both an anhedonic-like and an amnesic effect of {UCMS} in {CBA}/H mice. 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