Hearing status in adult individuals with lifetime, untreated isolated growth hormone deficiency. Prado-Barreto, V. M., Salvatori, R., Santos Júnior, R. C., Brandão-Martins, M. B., Correa, E. A., Garcez, F. B., Valença, E. H. O., Souza, A. H. O., Pereira, R. M. C., Nunes, M. A. P., D'Avila, J. S., & Aguiar-Oliveira, M. H. Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(3):464–471, March, 2014. Number: 3 Place: Englanddoi abstract bibtex OBJECTIVE: To evaluate the hearing status of growth hormone (GH)-naive adults with isolated GH deficiency (IGHD) belonging to an extended Brazilian kindred with a homozygous mutation in the GH-releasing hormone receptor gene. STUDY DESIGN: Cross-sectional. SETTING: Divisions of Endocrinology and Otorhinolaryngology of the Federal University of Sergipe. SUBJECTS AND METHODS: Twenty-six individuals with IGHD (age, 47.6 ± 15.1 years; 13 women) and 25 controls (age, 46.3 ± 14.3 years; 15 women) were administered a questionnaire on hearing complaints and hearing health history. We performed pure-tone audiometry, logoaudiometry, electroacoustic immittance, and stapedial reflex. To assess outer hair cell function in the cochlea, we completed transient evoked otoacoustic emissions (TEOAEs). To assess the auditory nerve and auditory brainstem, we obtained auditory brainstem responses (ABRs). RESULTS: Misophonia and dizziness complaints were more frequent in those with IGHD than in controls (P = .011). Patients with IGHD had higher thresholds at 250 Hz (P = .005), 500 Hz (P = .006), 3 KHz (P = .008), 4 KHz (P = .038), 6 KHz (P = .008), and 8 KHz (P = .048) and mild high-tones hearing loss (P = .029). Stapedial reflex (P \textless .001) and TEOAEs (P = .025) were more frequent in controls. There were no differences in ABR latencies. Hearing loss in patients with IGHD occurred earlier than in controls (P \textless .001). CONCLUSION: Compared with controls of the same area, subjects with untreated, congenital lifetime IGHD report more misophonia and dizziness, have predominance of mild high-tones sensorineural hearing loss, and have an absence of stapedial reflex and TEOAEs.
@article{prado-barreto_hearing_2014,
title = {Hearing status in adult individuals with lifetime, untreated isolated growth hormone deficiency.},
volume = {150},
issn = {1097-6817 0194-5998},
doi = {10.1177/0194599813517987},
abstract = {OBJECTIVE: To evaluate the hearing status of growth hormone (GH)-naive adults with isolated GH deficiency (IGHD) belonging to an extended Brazilian kindred with a homozygous mutation in the GH-releasing hormone receptor gene. STUDY DESIGN: Cross-sectional. SETTING: Divisions of Endocrinology and Otorhinolaryngology of the Federal University of Sergipe. SUBJECTS AND METHODS: Twenty-six individuals with IGHD (age, 47.6 ± 15.1 years; 13 women) and 25 controls (age, 46.3 ± 14.3 years; 15 women) were administered a questionnaire on hearing complaints and hearing health history. We performed pure-tone audiometry, logoaudiometry, electroacoustic immittance, and stapedial reflex. To assess outer hair cell function in the cochlea, we completed transient evoked otoacoustic emissions (TEOAEs). To assess the auditory nerve and auditory brainstem, we obtained auditory brainstem responses (ABRs). RESULTS: Misophonia and dizziness complaints were more frequent in those with IGHD than in controls (P = .011). Patients with IGHD had higher thresholds at 250 Hz (P = .005), 500 Hz (P = .006), 3 KHz (P = .008), 4 KHz (P = .038), 6 KHz (P = .008), and 8 KHz (P = .048) and mild high-tones hearing loss (P = .029). Stapedial reflex (P {\textless} .001) and TEOAEs (P = .025) were more frequent in controls. There were no differences in ABR latencies. Hearing loss in patients with IGHD occurred earlier than in controls (P {\textless} .001). CONCLUSION: Compared with controls of the same area, subjects with untreated, congenital lifetime IGHD report more misophonia and dizziness, have predominance of mild high-tones sensorineural hearing loss, and have an absence of stapedial reflex and TEOAEs.},
language = {eng},
number = {3},
journal = {Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},
author = {Prado-Barreto, Valéria M. and Salvatori, Roberto and Santos Júnior, Ronaldo C. and Brandão-Martins, Mariane B. and Correa, Eric A. and Garcez, Flávia B. and Valença, Eugênia H. O. and Souza, Anita H. O. and Pereira, Rossana M. C. and Nunes, Marco A. P. and D'Avila, Jeferson S. and Aguiar-Oliveira, Manuel H.},
month = mar,
year = {2014},
pmid = {24398366},
note = {Number: 3
Place: England},
keywords = {Adult, Audiometry, Pure-Tone, Brazil/epidemiology, Cross-Sectional Studies, Dwarfism, Pituitary/complications/*physiopathology, Female, Hearing Loss/epidemiology/etiology/*physiopathology, Hearing/*physiology, Humans, Incidence, Male, Middle Aged, Otoacoustic Emissions, Spontaneous, Surveys and Questionnaires, hearing, hearing loss, isolated growth hormone deficiency},
pages = {464--471},
}
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SETTING: Divisions of Endocrinology and Otorhinolaryngology of the Federal University of Sergipe. SUBJECTS AND METHODS: Twenty-six individuals with IGHD (age, 47.6 ± 15.1 years; 13 women) and 25 controls (age, 46.3 ± 14.3 years; 15 women) were administered a questionnaire on hearing complaints and hearing health history. We performed pure-tone audiometry, logoaudiometry, electroacoustic immittance, and stapedial reflex. To assess outer hair cell function in the cochlea, we completed transient evoked otoacoustic emissions (TEOAEs). To assess the auditory nerve and auditory brainstem, we obtained auditory brainstem responses (ABRs). RESULTS: Misophonia and dizziness complaints were more frequent in those with IGHD than in controls (P = .011). Patients with IGHD had higher thresholds at 250 Hz (P = .005), 500 Hz (P = .006), 3 KHz (P = .008), 4 KHz (P = .038), 6 KHz (P = .008), and 8 KHz (P = .048) and mild high-tones hearing loss (P = .029). Stapedial reflex (P \\textless .001) and TEOAEs (P = .025) were more frequent in controls. There were no differences in ABR latencies. Hearing loss in patients with IGHD occurred earlier than in controls (P \\textless .001). CONCLUSION: Compared with controls of the same area, subjects with untreated, congenital lifetime IGHD report more misophonia and dizziness, have predominance of mild high-tones sensorineural hearing loss, and have an absence of stapedial reflex and TEOAEs.","language":"eng","number":"3","journal":"Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery","author":[{"propositions":[],"lastnames":["Prado-Barreto"],"firstnames":["Valéria","M."],"suffixes":[]},{"propositions":[],"lastnames":["Salvatori"],"firstnames":["Roberto"],"suffixes":[]},{"propositions":[],"lastnames":["Santos","Júnior"],"firstnames":["Ronaldo","C."],"suffixes":[]},{"propositions":[],"lastnames":["Brandão-Martins"],"firstnames":["Mariane","B."],"suffixes":[]},{"propositions":[],"lastnames":["Correa"],"firstnames":["Eric","A."],"suffixes":[]},{"propositions":[],"lastnames":["Garcez"],"firstnames":["Flávia","B."],"suffixes":[]},{"propositions":[],"lastnames":["Valença"],"firstnames":["Eugênia","H.","O."],"suffixes":[]},{"propositions":[],"lastnames":["Souza"],"firstnames":["Anita","H.","O."],"suffixes":[]},{"propositions":[],"lastnames":["Pereira"],"firstnames":["Rossana","M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Nunes"],"firstnames":["Marco","A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["D'Avila"],"firstnames":["Jeferson","S."],"suffixes":[]},{"propositions":[],"lastnames":["Aguiar-Oliveira"],"firstnames":["Manuel","H."],"suffixes":[]}],"month":"March","year":"2014","pmid":"24398366","note":"Number: 3 Place: England","keywords":"Adult, Audiometry, Pure-Tone, Brazil/epidemiology, Cross-Sectional Studies, Dwarfism, Pituitary/complications/*physiopathology, Female, Hearing Loss/epidemiology/etiology/*physiopathology, Hearing/*physiology, Humans, Incidence, Male, Middle Aged, Otoacoustic Emissions, Spontaneous, Surveys and Questionnaires, hearing, hearing loss, isolated growth hormone deficiency","pages":"464–471","bibtex":"@article{prado-barreto_hearing_2014,\n\ttitle = {Hearing status in adult individuals with lifetime, untreated isolated growth hormone deficiency.},\n\tvolume = {150},\n\tissn = {1097-6817 0194-5998},\n\tdoi = {10.1177/0194599813517987},\n\tabstract = {OBJECTIVE: To evaluate the hearing status of growth hormone (GH)-naive adults with isolated GH deficiency (IGHD) belonging to an extended Brazilian kindred with a homozygous mutation in the GH-releasing hormone receptor gene. STUDY DESIGN: Cross-sectional. SETTING: Divisions of Endocrinology and Otorhinolaryngology of the Federal University of Sergipe. SUBJECTS AND METHODS: Twenty-six individuals with IGHD (age, 47.6 ± 15.1 years; 13 women) and 25 controls (age, 46.3 ± 14.3 years; 15 women) were administered a questionnaire on hearing complaints and hearing health history. We performed pure-tone audiometry, logoaudiometry, electroacoustic immittance, and stapedial reflex. To assess outer hair cell function in the cochlea, we completed transient evoked otoacoustic emissions (TEOAEs). To assess the auditory nerve and auditory brainstem, we obtained auditory brainstem responses (ABRs). RESULTS: Misophonia and dizziness complaints were more frequent in those with IGHD than in controls (P = .011). Patients with IGHD had higher thresholds at 250 Hz (P = .005), 500 Hz (P = .006), 3 KHz (P = .008), 4 KHz (P = .038), 6 KHz (P = .008), and 8 KHz (P = .048) and mild high-tones hearing loss (P = .029). Stapedial reflex (P {\\textless} .001) and TEOAEs (P = .025) were more frequent in controls. There were no differences in ABR latencies. Hearing loss in patients with IGHD occurred earlier than in controls (P {\\textless} .001). CONCLUSION: Compared with controls of the same area, subjects with untreated, congenital lifetime IGHD report more misophonia and dizziness, have predominance of mild high-tones sensorineural hearing loss, and have an absence of stapedial reflex and TEOAEs.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},\n\tauthor = {Prado-Barreto, Valéria M. and Salvatori, Roberto and Santos Júnior, Ronaldo C. and Brandão-Martins, Mariane B. and Correa, Eric A. and Garcez, Flávia B. and Valença, Eugênia H. O. and Souza, Anita H. O. and Pereira, Rossana M. C. and Nunes, Marco A. P. and D'Avila, Jeferson S. and Aguiar-Oliveira, Manuel H.},\n\tmonth = mar,\n\tyear = {2014},\n\tpmid = {24398366},\n\tnote = {Number: 3\nPlace: England},\n\tkeywords = {Adult, Audiometry, Pure-Tone, Brazil/epidemiology, Cross-Sectional Studies, Dwarfism, Pituitary/complications/*physiopathology, Female, Hearing Loss/epidemiology/etiology/*physiopathology, Hearing/*physiology, Humans, Incidence, Male, Middle Aged, Otoacoustic Emissions, Spontaneous, Surveys and Questionnaires, hearing, hearing loss, isolated growth hormone deficiency},\n\tpages = {464--471},\n}\n\n","author_short":["Prado-Barreto, V. M.","Salvatori, R.","Santos Júnior, R. C.","Brandão-Martins, M. B.","Correa, E. A.","Garcez, F. B.","Valença, E. H. O.","Souza, A. H. O.","Pereira, R. M. C.","Nunes, M. A. P.","D'Avila, J. S.","Aguiar-Oliveira, M. 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