@article{prasad_quantitative_2024,
	title = {Quantitative {Proteomics} for {Translational} {Pharmacology} and {Precision} {Medicine}: {State} of {The} {Art} and {Future} {Outlook}},
	copyright = {Copyright © 2024 American Society for Pharmacology and Experimental Therapeutics},
	issn = {0090-9556, 1521-009X},
	shorttitle = {Quantitative {Proteomics} for {Translational} {Pharmacology} and {Precision} {Medicine}},
	url = {https://dmd.aspetjournals.org/content/early/2024/05/31/dmd.124.001600},
	doi = {10.1124/dmd.124.001600},
	abstract = {Over the past 20 years, quantitative proteomics has contributed a wealth of protein expression data, which are currently used for a variety of systems pharmacology applications, as a complement or a surrogate for activity of the corresponding proteins. A symposium at the 25th North American ISSX meeting, in Boston, in September 2023, was held to explore current and emerging applications of quantitative proteomics in translational pharmacology and strategies for improved integration into model-informed drug development based on practical experience of each of the presenters. A summary of the talks and discussions is presented in this perspective alongside future outlooks that were outlined for future meetings.
Significance Statement This perspective explores current and emerging applications of quantitative proteomics in translational pharmacology and precision medicine, and outlines outlooks for improved integration into model-informed drug development.},
	language = {en},
	urldate = {2024-06-10},
	journal = {Drug Metabolism and Disposition},
	author = {Prasad, Bhagwat and Al-Majdoub, Zubida M. and Wegler, Christine and Rostami-Hodjegan, Amin and Achour, Brahim},
	month = jan,
	year = {2024},
	pmid = {38821856},
	note = {Publisher: American Society for Pharmacology and Experimental Therapeutics
Section: Minireview},
	keywords = {physiologically-based pharmacokinetic modeling/PBPK, proteomics, systems pharmacology},
}

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Significance Statement This perspective explores current and emerging applications of quantitative proteomics in translational pharmacology and precision medicine, and outlines outlooks for improved integration into model-informed drug development.","language":"en","urldate":"2024-06-10","journal":"Drug Metabolism and Disposition","author":[{"propositions":[],"lastnames":["Prasad"],"firstnames":["Bhagwat"],"suffixes":[]},{"propositions":[],"lastnames":["Al-Majdoub"],"firstnames":["Zubida","M."],"suffixes":[]},{"propositions":[],"lastnames":["Wegler"],"firstnames":["Christine"],"suffixes":[]},{"propositions":[],"lastnames":["Rostami-Hodjegan"],"firstnames":["Amin"],"suffixes":[]},{"propositions":[],"lastnames":["Achour"],"firstnames":["Brahim"],"suffixes":[]}],"month":"January","year":"2024","pmid":"38821856","note":"Publisher: American Society for Pharmacology and Experimental Therapeutics Section: Minireview","keywords":"physiologically-based pharmacokinetic modeling/PBPK, proteomics, systems pharmacology","bibtex":"@article{prasad_quantitative_2024,\n\ttitle = {Quantitative {Proteomics} for {Translational} {Pharmacology} and {Precision} {Medicine}: {State} of {The} {Art} and {Future} {Outlook}},\n\tcopyright = {Copyright © 2024 American Society for Pharmacology and Experimental Therapeutics},\n\tissn = {0090-9556, 1521-009X},\n\tshorttitle = {Quantitative {Proteomics} for {Translational} {Pharmacology} and {Precision} {Medicine}},\n\turl = {https://dmd.aspetjournals.org/content/early/2024/05/31/dmd.124.001600},\n\tdoi = {10.1124/dmd.124.001600},\n\tabstract = {Over the past 20 years, quantitative proteomics has contributed a wealth of protein expression data, which are currently used for a variety of systems pharmacology applications, as a complement or a surrogate for activity of the corresponding proteins. A symposium at the 25th North American ISSX meeting, in Boston, in September 2023, was held to explore current and emerging applications of quantitative proteomics in translational pharmacology and strategies for improved integration into model-informed drug development based on practical experience of each of the presenters. 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