@article{pritzker_osteoarthritis_2006,
	title = {Osteoarthritis cartilage histopathology: grading and staging},
	volume = {14},
	issn = {1063-4584},
	shorttitle = {Osteoarthritis cartilage histopathology},
	doi = {10.1016/j.joca.2005.07.014},
	abstract = {OBJECTIVE: Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method.
DESIGN: An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology.
RESULTS: An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed.
CONCLUSIONS: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.},
	language = {eng},
	number = {1},
	journal = {Osteoarthritis and Cartilage},
	author = {Pritzker, K. P. H. and Gay, S. and Jimenez, S. A. and Ostergaard, K. and Pelletier, J.-P. and Revell, P. A. and Salter, D. and van den Berg, W. B.},
	month = jan,
	year = {2006},
	pmid = {16242352},
	keywords = {Animals, Arthroscopy, Biomarkers, Bone Remodeling, Cartilage, Articular, Cell Division, Chondrocytes, Disease Models, Animal, Disease Progression, Humans, Hypertrophy, Joints, Osteoarthritis, Reproducibility of Results, Sclerosis, Terminology as Topic},
	pages = {13--29}
}

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DESIGN: An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology. RESULTS: An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed. CONCLUSIONS: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.","language":"eng","number":"1","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Pritzker"],"firstnames":["K.","P.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Gay"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Jimenez"],"firstnames":["S.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Ostergaard"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Pelletier"],"firstnames":["J.-P."],"suffixes":[]},{"propositions":[],"lastnames":["Revell"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Salter"],"firstnames":["D."],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Berg"],"firstnames":["W.","B."],"suffixes":[]}],"month":"January","year":"2006","pmid":"16242352","keywords":"Animals, Arthroscopy, Biomarkers, Bone Remodeling, Cartilage, Articular, Cell Division, Chondrocytes, Disease Models, Animal, Disease Progression, Humans, Hypertrophy, Joints, Osteoarthritis, Reproducibility of Results, Sclerosis, Terminology as Topic","pages":"13–29","bibtex":"@article{pritzker_osteoarthritis_2006,\n\ttitle = {Osteoarthritis cartilage histopathology: grading and staging},\n\tvolume = {14},\n\tissn = {1063-4584},\n\tshorttitle = {Osteoarthritis cartilage histopathology},\n\tdoi = {10.1016/j.joca.2005.07.014},\n\tabstract = {OBJECTIVE: Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method.\nDESIGN: An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology.\nRESULTS: An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed.\nCONCLUSIONS: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. 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