Induction of DNA damage by heavy ions measured by atomic force microscopy. Psonka, K., Brons, S., Heiss, M., Gudowska-Nowak, E., & Taucher-Scholz, G. Journal of Physics Condensed Matter, 17(18):S1443-S1446, 2005. Paper doi abstract bibtex According to the experimental evidence damage induced by densely ionizing radiation in chromosomes and DNA molecules is distributed in the form of clusters. The most critical type of DNA damage is double-strand breaks (DSBs) which are formed when breaks occur in both DNA strands and are directly opposite or separated by only a few base pairs. This paper reports on the direct visualization of DSBs induced in a plasmid DNA molecule by ionizing radiation and the measurement of produced DNA fragments by use of atomic force microscopy (AFM). Our results show an influence of radiation quality on the DSB production. © 2005 IOP Publishing Ltd.
@ARTICLE{Psonka2005,
author={Psonka, K. and Brons, S. and Heiss, M. and Gudowska-Nowak, E. and Taucher-Scholz, G.},
title={Induction of DNA damage by heavy ions measured by atomic force microscopy},
journal={Journal of Physics Condensed Matter},
year={2005},
volume={17},
number={18},
pages={S1443-S1446},
doi={10.1088/0953-8984/17/18/002},
url={https://www2.scopus.com/inward/record.uri?eid=2-s2.0-24144501093&doi=10.1088%2f0953-8984%2f17%2f18%2f002&partnerID=40&md5=a46a932a3763f3994c1d6c02d450d75a},
abstract={According to the experimental evidence damage induced by densely ionizing radiation in chromosomes and DNA molecules is distributed in the form of clusters. The most critical type of DNA damage is double-strand breaks (DSBs) which are formed when breaks occur in both DNA strands and are directly opposite or separated by only a few base pairs. This paper reports on the direct visualization of DSBs induced in a plasmid DNA molecule by ionizing radiation and the measurement of produced DNA fragments by use of atomic force microscopy (AFM). Our results show an influence of radiation quality on the DSB production. © 2005 IOP Publishing Ltd.},
keywords={Atomic force microscopy; DNA; Ionizing radiation; Molecular dynamics; Plasmas; Visualization, Double-strand breaks; Double-strand breaks (DSB); Plasmids; Radiation quality, Heavy ions},
document_type={Article},
source={Scopus},
}
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