Modeling the isolated cardiac myocyte. Puglisi, J., Wang, F., & Bers, D. Prog Biophys Mol Biol, 85(2-3):163–178, June-July, 2004. bibtex @Article{RSM:Pug2004,
author = "J.L. Puglisi and F. Wang and D.M. Bers",
title = "Modeling the isolated cardiac myocyte.",
journal = "Prog Biophys Mol Biol",
year = "2004",
month = jun # "-" # jul,
volume = "85",
number = "2-3",
pages = "163--178",
robnote = "Computer modeling of cardiac myocytes has flourished
in recent years. Models have evolved from mathematical
descriptions of ionic channels alone to more
sophisticated formulations that include calcium
transport mechanisms, ATP production and metabolic
pathways. The increased complexity is fueled by the new
data available in the field. The continuous production
of experimental data has led to the evolution of
increasingly refined descriptions of the phenomena by
modelers. Integrating the numerous systems involved in
cardiac myocyte homeostasis makes the use of computer
models necessary due to the unreliability of intuitive
approaches. However the complexity of the model should
not imply a cumbersome operation of the program. As
with any tool, computer models have to be easy to
operate or their strength will be diminished and
potential users will not benefit fully from them. The
contribution of the computer modeler to their
respective biological fields will be more successful
and enduring if modelers devote sufficient time to
implement their equations into a model with
user-friendly characteristics.",
bibdate = "Mon Nov 20 07:50:06 2006",
}
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