{"_id":"4BDLy2JfAdwgd7wqx","bibbaseid":"punske-rossi-ershler-rasmussen-abel-opticalmappingofpropagationchangesinducedbyelevatedextracellularpotassiumionconcentrationingeneticallyalteredmousehearts-2004","downloads":0,"creationDate":"2016-07-01T21:38:39.425Z","title":"Optical mapping of propagation changes induced by elevated extracellular potassium ion concentration in genetically altered mouse hearts.","author_short":["Punske, B.","Rossi, S.","Ershler, P.","Rasmussen, I.","Abel, E."],"year":2004,"bibtype":"article","biburl":"http://www.sci.utah.edu/~macleod/Bibtex/biglit.bib","bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["B.B."],"propositions":[],"lastnames":["Punske"],"suffixes":[]},{"firstnames":["S."],"propositions":[],"lastnames":["Rossi"],"suffixes":[]},{"firstnames":["P."],"propositions":[],"lastnames":["Ershler"],"suffixes":[]},{"firstnames":["I."],"propositions":[],"lastnames":["Rasmussen"],"suffixes":[]},{"firstnames":["E.D."],"propositions":[],"lastnames":["Abel"],"suffixes":[]}],"title":"Optical mapping of propagation changes induced by elevated extracellular potassium ion concentration in genetically altered mouse hearts.","journal":"j-JE","year":"2004","volume":"37 Suppl","pages":"128--134","robnote":"Lack of insulin receptors in mouse myocytes has been shown to reduce repolarizing potassium currents and prolong action potential duration. We hypothesized that these changes would manifest as rate-related effects on electrical propagation in the intact heart. This study employed optical mapping to characterize propagation changes in intact mouse hearts with cardiomyocyte-restricted knock out of insulin receptors (CIRKO). None of the 8 CIRKO hearts maintained regular responses to atrial stimulation at the 160 ms cycle length under normal conditions; however, all of the WT hearts were captured at this rate. Total activation time for a 4 mm by 4 mm area was longer for CIRKO hearts when compared with WT. Average epicardial conduction velocity was slower for the CIRKO when compared to WT. Propagation delay due to the presence of high [K+]e was significant in both CIRKO and WT mice, but significantly longer for the CIRKO hearts. CONCLUSIONS: These results show that in addition to reducing repolarization currents, impaired myocardial insulin signaling leads to impaired electrical impulse propagation particularly at increased heart rates. These data suggest a link between impaired myocardial insulin signaling and the increased risk of arrhythmia and sudden death in patients with diabetes.","bibdate":"Thu Dec 28 15:49:33 2006","bibtex":"@Article{RSM:Pun2004,\n author = \"B.B. Punske and S. Rossi and P. Ershler and I.\n Rasmussen and E.D. Abel\",\n title = \"Optical mapping of propagation changes induced by\n elevated extracellular potassium ion concentration in\n genetically altered mouse hearts.\",\n journal = j-JE,\n year = \"2004\",\n volume = \"37 Suppl\",\n pages = \"128--134\",\n robnote = \"Lack of insulin receptors in mouse myocytes has been\n shown to reduce repolarizing potassium currents and\n prolong action potential duration. We hypothesized that\n these changes would manifest as rate-related effects on\n electrical propagation in the intact heart. This study\n employed optical mapping to characterize propagation\n changes in intact mouse hearts with\n cardiomyocyte-restricted knock out of insulin receptors\n (CIRKO). None of the 8 CIRKO hearts maintained regular\n responses to atrial stimulation at the 160 ms cycle\n length under normal conditions; however, all of the WT\n hearts were captured at this rate. Total activation\n time for a 4 mm by 4 mm area was longer for CIRKO\n hearts when compared with WT. Average epicardial\n conduction velocity was slower for the CIRKO when\n compared to WT. Propagation delay due to the presence\n of high [K+]e was significant in both CIRKO and WT\n mice, but significantly longer for the CIRKO hearts.\n CONCLUSIONS: These results show that in addition to\n reducing repolarization currents, impaired myocardial\n insulin signaling leads to impaired electrical impulse\n propagation particularly at increased heart rates.\n These data suggest a link between impaired myocardial\n insulin signaling and the increased risk of arrhythmia\n and sudden death in patients with diabetes.\",\n bibdate = \"Thu Dec 28 15:49:33 2006\",\n}\n\n\n","author_short":["Punske, B.","Rossi, S.","Ershler, P.","Rasmussen, I.","Abel, E."],"key":"RSM:Pun2004","id":"RSM:Pun2004","bibbaseid":"punske-rossi-ershler-rasmussen-abel-opticalmappingofpropagationchangesinducedbyelevatedextracellularpotassiumionconcentrationingeneticallyalteredmousehearts-2004","role":"author","urls":{},"downloads":0,"html":""},"search_terms":["optical","mapping","propagation","changes","induced","elevated","extracellular","potassium","ion","concentration","genetically","altered","mouse","hearts","punske","rossi","ershler","rasmussen","abel"],"keywords":[],"authorIDs":[],"dataSources":["5HG3Kp8zRwDd7FotB"]}