Inhibition of WISE preserves renal allograft function. Qian, X., Yuan, X., Vonderfecht, S., Ge, X., Lee, J., Jurisch, A., Zhang, L., You, A., Fitzpatrick, V., D., Williams, A., Valente, E., G., Pretorius, J., Stevens, J., L., Tipton, B., Winters, A., G., Graham, K., Harriss, L., Baker, D., M., Damore, M., Salimi-Moosavi, H., Gao, Y., Elkhal, A., Paszty, C., Simonet, W., S., Richards, W., G., & Tullius, S., G. Journal of the American Society of Nephrology : JASN, 24(1):66-76, 1, 2013. ![Inhibition of WISE preserves renal allograft function. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex Wnt-modulator in surface ectoderm (WISE) is a secreted modulator of Wnt signaling expressed in the adult kidney. Activation of Wnt signaling has been observed in renal transplants developing interstitial fibrosis and tubular atrophy; however, whether WISE contributes to chronic changes is not well understood. Here, we found moderate to high expression of WISE mRNA in a rat model of renal transplantation and in kidneys from normal rats. Treatment with a neutralizing antibody against WISE improved proteinuria and graft function, which correlated with higher levels of β-catenin protein in kidney allografts. In addition, treatment with the anti-WISE antibody reduced infiltration of CD68(+) macrophages and CD8(+) T cells, attenuated glomerular and interstitial injury, and decreased biomarkers of renal injury. This treatment reduced expression of genes involved in immune responses and in fibrogenic pathways. In summary, WISE contributes to renal dysfunction by promoting tubular atrophy and interstitial fibrosis.
@article{
title = {Inhibition of WISE preserves renal allograft function.},
type = {article},
year = {2013},
identifiers = {[object Object]},
keywords = {Actins,Actins: metabolism,Animals,Antibodies,Antibodies: therapeutic use,Biological Markers,Biological Markers: urine,Cadherins,Cadherins: metabolism,Carrier Proteins,Carrier Proteins: antagonists & inhibitors,Carrier Proteins: metabolism,Epithelial Cells,Epithelial Cells: metabolism,Fibroblasts,Fibroblasts: metabolism,Gene Expression,Humans,Kidney,Kidney Function Tests,Kidney Transplantation,Kidney: immunology,Kidney: metabolism,Male,Rats,Rats, Inbred F344,Rats, Inbred Lew,Renal Insufficiency,Renal Insufficiency: prevention & control,Renal Insufficiency: urine,Wnt Proteins,Wnt Proteins: metabolism,beta Catenin,beta Catenin: metabolism},
pages = {66-76},
volume = {24},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/23184054},
month = {1},
id = {306d0591-66a9-35c8-a2ab-303f8387e6ce},
created = {2013-05-21T17:23:53.000Z},
accessed = {2013-05-21},
file_attached = {false},
profile_id = {78cdc22a-9ab8-3dbd-9671-594a07f2c020},
group_id = {60cd19b5-2fd5-3898-a22e-e5732aded4d6},
last_modified = {2017-03-14T12:00:36.003Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
citation_key = {Qian2013},
private_publication = {false},
abstract = {Wnt-modulator in surface ectoderm (WISE) is a secreted modulator of Wnt signaling expressed in the adult kidney. Activation of Wnt signaling has been observed in renal transplants developing interstitial fibrosis and tubular atrophy; however, whether WISE contributes to chronic changes is not well understood. Here, we found moderate to high expression of WISE mRNA in a rat model of renal transplantation and in kidneys from normal rats. Treatment with a neutralizing antibody against WISE improved proteinuria and graft function, which correlated with higher levels of β-catenin protein in kidney allografts. In addition, treatment with the anti-WISE antibody reduced infiltration of CD68(+) macrophages and CD8(+) T cells, attenuated glomerular and interstitial injury, and decreased biomarkers of renal injury. This treatment reduced expression of genes involved in immune responses and in fibrogenic pathways. In summary, WISE contributes to renal dysfunction by promoting tubular atrophy and interstitial fibrosis.},
bibtype = {article},
author = {Qian, Xueming and Yuan, Xiaodong and Vonderfecht, Steven and Ge, Xupeng and Lee, Jae and Jurisch, Anke and Zhang, Li and You, Andrew and Fitzpatrick, Vincent D and Williams, Alexia and Valente, Eliane G and Pretorius, Jim and Stevens, Jennitte L and Tipton, Barbara and Winters, Aaron G and Graham, Kevin and Harriss, Lindsey and Baker, Daniel M and Damore, Michael and Salimi-Moosavi, Hossein and Gao, Yongming and Elkhal, Abdallah and Paszty, Chris and Simonet, W Scott and Richards, William G and Tullius, Stefan G},
journal = {Journal of the American Society of Nephrology : JASN},
number = {1}
}
Downloads: 0
{"_id":"ZrNgeAZe5mkMaLyeJ","bibbaseid":"qian-yuan-vonderfecht-ge-lee-jurisch-zhang-you-etal-inhibitionofwisepreservesrenalallograftfunction-2013","downloads":0,"creationDate":"2018-02-27T08:49:02.034Z","title":"Inhibition of WISE preserves renal allograft function.","author_short":["Qian, X.","Yuan, X.","Vonderfecht, S.","Ge, X.","Lee, J.","Jurisch, A.","Zhang, L.","You, A.","Fitzpatrick, V., D.","Williams, A.","Valente, E., G.","Pretorius, J.","Stevens, J., L.","Tipton, B.","Winters, A., G.","Graham, K.","Harriss, L.","Baker, D., M.","Damore, M.","Salimi-Moosavi, H.","Gao, Y.","Elkhal, A.","Paszty, C.","Simonet, W., S.","Richards, W., G.","Tullius, S., G."],"year":2013,"bibtype":"article","biburl":null,"bibdata":{"title":"Inhibition of WISE preserves renal allograft function.","type":"article","year":"2013","identifiers":"[object Object]","keywords":"Actins,Actins: metabolism,Animals,Antibodies,Antibodies: therapeutic use,Biological Markers,Biological Markers: urine,Cadherins,Cadherins: metabolism,Carrier Proteins,Carrier Proteins: antagonists & inhibitors,Carrier Proteins: metabolism,Epithelial Cells,Epithelial Cells: metabolism,Fibroblasts,Fibroblasts: metabolism,Gene Expression,Humans,Kidney,Kidney Function Tests,Kidney Transplantation,Kidney: immunology,Kidney: metabolism,Male,Rats,Rats, Inbred F344,Rats, Inbred Lew,Renal Insufficiency,Renal Insufficiency: prevention & control,Renal Insufficiency: urine,Wnt Proteins,Wnt Proteins: metabolism,beta Catenin,beta Catenin: metabolism","pages":"66-76","volume":"24","websites":"http://www.ncbi.nlm.nih.gov/pubmed/23184054","month":"1","id":"306d0591-66a9-35c8-a2ab-303f8387e6ce","created":"2013-05-21T17:23:53.000Z","accessed":"2013-05-21","file_attached":false,"profile_id":"78cdc22a-9ab8-3dbd-9671-594a07f2c020","group_id":"60cd19b5-2fd5-3898-a22e-e5732aded4d6","last_modified":"2017-03-14T12:00:36.003Z","read":false,"starred":false,"authored":false,"confirmed":"true","hidden":false,"citation_key":"Qian2013","private_publication":false,"abstract":"Wnt-modulator in surface ectoderm (WISE) is a secreted modulator of Wnt signaling expressed in the adult kidney. Activation of Wnt signaling has been observed in renal transplants developing interstitial fibrosis and tubular atrophy; however, whether WISE contributes to chronic changes is not well understood. Here, we found moderate to high expression of WISE mRNA in a rat model of renal transplantation and in kidneys from normal rats. Treatment with a neutralizing antibody against WISE improved proteinuria and graft function, which correlated with higher levels of β-catenin protein in kidney allografts. In addition, treatment with the anti-WISE antibody reduced infiltration of CD68(+) macrophages and CD8(+) T cells, attenuated glomerular and interstitial injury, and decreased biomarkers of renal injury. This treatment reduced expression of genes involved in immune responses and in fibrogenic pathways. In summary, WISE contributes to renal dysfunction by promoting tubular atrophy and interstitial fibrosis.","bibtype":"article","author":"Qian, Xueming and Yuan, Xiaodong and Vonderfecht, Steven and Ge, Xupeng and Lee, Jae and Jurisch, Anke and Zhang, Li and You, Andrew and Fitzpatrick, Vincent D and Williams, Alexia and Valente, Eliane G and Pretorius, Jim and Stevens, Jennitte L and Tipton, Barbara and Winters, Aaron G and Graham, Kevin and Harriss, Lindsey and Baker, Daniel M and Damore, Michael and Salimi-Moosavi, Hossein and Gao, Yongming and Elkhal, Abdallah and Paszty, Chris and Simonet, W Scott and Richards, William G and Tullius, Stefan G","journal":"Journal of the American Society of Nephrology : JASN","number":"1","bibtex":"@article{\n title = {Inhibition of WISE preserves renal allograft function.},\n type = {article},\n year = {2013},\n identifiers = {[object Object]},\n keywords = {Actins,Actins: metabolism,Animals,Antibodies,Antibodies: therapeutic use,Biological Markers,Biological Markers: urine,Cadherins,Cadherins: metabolism,Carrier Proteins,Carrier Proteins: antagonists & inhibitors,Carrier Proteins: metabolism,Epithelial Cells,Epithelial Cells: metabolism,Fibroblasts,Fibroblasts: metabolism,Gene Expression,Humans,Kidney,Kidney Function Tests,Kidney Transplantation,Kidney: immunology,Kidney: metabolism,Male,Rats,Rats, Inbred F344,Rats, Inbred Lew,Renal Insufficiency,Renal Insufficiency: prevention & control,Renal Insufficiency: urine,Wnt Proteins,Wnt Proteins: metabolism,beta Catenin,beta Catenin: metabolism},\n pages = {66-76},\n volume = {24},\n websites = {http://www.ncbi.nlm.nih.gov/pubmed/23184054},\n month = {1},\n id = {306d0591-66a9-35c8-a2ab-303f8387e6ce},\n created = {2013-05-21T17:23:53.000Z},\n accessed = {2013-05-21},\n file_attached = {false},\n profile_id = {78cdc22a-9ab8-3dbd-9671-594a07f2c020},\n group_id = {60cd19b5-2fd5-3898-a22e-e5732aded4d6},\n last_modified = {2017-03-14T12:00:36.003Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n citation_key = {Qian2013},\n private_publication = {false},\n abstract = {Wnt-modulator in surface ectoderm (WISE) is a secreted modulator of Wnt signaling expressed in the adult kidney. Activation of Wnt signaling has been observed in renal transplants developing interstitial fibrosis and tubular atrophy; however, whether WISE contributes to chronic changes is not well understood. Here, we found moderate to high expression of WISE mRNA in a rat model of renal transplantation and in kidneys from normal rats. Treatment with a neutralizing antibody against WISE improved proteinuria and graft function, which correlated with higher levels of β-catenin protein in kidney allografts. In addition, treatment with the anti-WISE antibody reduced infiltration of CD68(+) macrophages and CD8(+) T cells, attenuated glomerular and interstitial injury, and decreased biomarkers of renal injury. This treatment reduced expression of genes involved in immune responses and in fibrogenic pathways. In summary, WISE contributes to renal dysfunction by promoting tubular atrophy and interstitial fibrosis.},\n bibtype = {article},\n author = {Qian, Xueming and Yuan, Xiaodong and Vonderfecht, Steven and Ge, Xupeng and Lee, Jae and Jurisch, Anke and Zhang, Li and You, Andrew and Fitzpatrick, Vincent D and Williams, Alexia and Valente, Eliane G and Pretorius, Jim and Stevens, Jennitte L and Tipton, Barbara and Winters, Aaron G and Graham, Kevin and Harriss, Lindsey and Baker, Daniel M and Damore, Michael and Salimi-Moosavi, Hossein and Gao, Yongming and Elkhal, Abdallah and Paszty, Chris and Simonet, W Scott and Richards, William G and Tullius, Stefan G},\n journal = {Journal of the American Society of Nephrology : JASN},\n number = {1}\n}","author_short":["Qian, X.","Yuan, X.","Vonderfecht, S.","Ge, X.","Lee, J.","Jurisch, A.","Zhang, L.","You, A.","Fitzpatrick, V., D.","Williams, A.","Valente, E., G.","Pretorius, J.","Stevens, J., L.","Tipton, B.","Winters, A., G.","Graham, K.","Harriss, L.","Baker, D., M.","Damore, M.","Salimi-Moosavi, H.","Gao, Y.","Elkhal, A.","Paszty, C.","Simonet, W., S.","Richards, W., G.","Tullius, S., G."],"urls":{"Website":"http://www.ncbi.nlm.nih.gov/pubmed/23184054"},"bibbaseid":"qian-yuan-vonderfecht-ge-lee-jurisch-zhang-you-etal-inhibitionofwisepreservesrenalallograftfunction-2013","role":"author","keyword":["Actins","Actins: metabolism","Animals","Antibodies","Antibodies: therapeutic use","Biological Markers","Biological Markers: urine","Cadherins","Cadherins: metabolism","Carrier Proteins","Carrier Proteins: antagonists & inhibitors","Carrier Proteins: metabolism","Epithelial Cells","Epithelial Cells: metabolism","Fibroblasts","Fibroblasts: metabolism","Gene Expression","Humans","Kidney","Kidney Function Tests","Kidney Transplantation","Kidney: immunology","Kidney: metabolism","Male","Rats","Rats","Inbred F344","Rats","Inbred Lew","Renal Insufficiency","Renal Insufficiency: prevention & control","Renal Insufficiency: urine","Wnt Proteins","Wnt Proteins: metabolism","beta Catenin","beta Catenin: metabolism"],"downloads":0},"search_terms":["inhibition","wise","preserves","renal","allograft","function","qian","yuan","vonderfecht","ge","lee","jurisch","zhang","you","fitzpatrick","williams","valente","pretorius","stevens","tipton","winters","graham","harriss","baker","damore","salimi-moosavi","gao","elkhal","paszty","simonet","richards","tullius"],"keywords":["actins","actins: metabolism","animals","antibodies","antibodies: therapeutic use","biological markers","biological markers: urine","cadherins","cadherins: metabolism","carrier proteins","carrier proteins: antagonists & inhibitors","carrier proteins: metabolism","epithelial cells","epithelial cells: metabolism","fibroblasts","fibroblasts: metabolism","gene expression","humans","kidney","kidney function tests","kidney transplantation","kidney: immunology","kidney: metabolism","male","rats","rats","inbred f344","rats","inbred lew","renal insufficiency","renal insufficiency: prevention & control","renal insufficiency: urine","wnt proteins","wnt proteins: metabolism","beta catenin","beta catenin: metabolism"],"authorIDs":[]}