Cell cycle regulation and cell type-specific localization of the FtsZ division initiation protein in Caulobacter. Quardokus, E, Din, N, & Brun, Y V Proceedings of the National Academy of Sciences of the United States of America, 93(13):6314--6319, June, 1996. ![Cell cycle regulation and cell type-specific localization of the FtsZ division initiation protein in Caulobacter [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Many genes involved in cell division and DNA replication and their protein products have been identified in bacteria; however, little is known about the cell cycle regulation of the intracellular concentration of these proteins. It has been shown that the level of the tubulin-like GTPase FtsZ is critical for the initiation of cell division in bacteria. We show that the concentration of FtsZ varies dramatically during the cell cycle of Caulobacter crescentus. Caulobacter produce two different cell types at each cell division: (i) a sessile stalked cell that can initiate DNA replication immediately after cell division and (ii) a motile swarmer cell in which DNA replication is blocked. After cell division, only the stalked cell contains FtsZ. FtsZ is synthesized slightly before the swarmer cells differentiate into stalked cells and the intracellular concentration of FtsZ is maximal at the beginning of cell division. Late in the cell cycle, after the completion of chromosome replication, the level of FtsZ decreases dramatically. This decrease is probably mostly due to the degradation of FtsZ in the swarmer compartment of the predivisional cell. Thus, the variation of FtsZ concentration parallels the pattern of DNA synthesis. Constitutive expression of FtsZ leads to defects in stalk biosynthesis suggesting a role for FtsZ in this developmental process in addition to its role in cell division.
@article{quardokus_cell_1996,
title = {Cell cycle regulation and cell type-specific localization of the {FtsZ} division initiation protein in {Caulobacter}},
volume = {93},
issn = {0027-8424},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8692812},
abstract = {Many genes involved in cell division and DNA replication and their protein products have been identified in bacteria; however, little is known about the cell cycle regulation of the intracellular concentration of these proteins. It has been shown that the level of the tubulin-like GTPase FtsZ is critical for the initiation of cell division in bacteria. We show that the concentration of FtsZ varies dramatically during the cell cycle of Caulobacter crescentus. Caulobacter produce two different cell types at each cell division: (i) a sessile stalked cell that can initiate DNA replication immediately after cell division and (ii) a motile swarmer cell in which DNA replication is blocked. After cell division, only the stalked cell contains FtsZ. FtsZ is synthesized slightly before the swarmer cells differentiate into stalked cells and the intracellular concentration of FtsZ is maximal at the beginning of cell division. Late in the cell cycle, after the completion of chromosome replication, the level of FtsZ decreases dramatically. This decrease is probably mostly due to the degradation of FtsZ in the swarmer compartment of the predivisional cell. Thus, the variation of FtsZ concentration parallels the pattern of DNA synthesis. Constitutive expression of FtsZ leads to defects in stalk biosynthesis suggesting a role for FtsZ in this developmental process in addition to its role in cell division.},
number = {13},
urldate = {2010-08-01TZ},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
author = {Quardokus, E and Din, N and Brun, Y V},
month = jun,
year = {1996},
pmid = {8692812},
keywords = {Amino Acid Sequence, Bacterial Proteins, Caulobacter, Cell Cycle, Cloning, Molecular, Cytoskeletal Proteins, Escherichia coli, Molecular Sequence Data, Sequence Homology, Amino Acid},
pages = {6314--6319}
}
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It has been shown that the level of the tubulin-like GTPase FtsZ is critical for the initiation of cell division in bacteria. We show that the concentration of FtsZ varies dramatically during the cell cycle of Caulobacter crescentus. Caulobacter produce two different cell types at each cell division: (i) a sessile stalked cell that can initiate DNA replication immediately after cell division and (ii) a motile swarmer cell in which DNA replication is blocked. After cell division, only the stalked cell contains FtsZ. FtsZ is synthesized slightly before the swarmer cells differentiate into stalked cells and the intracellular concentration of FtsZ is maximal at the beginning of cell division. Late in the cell cycle, after the completion of chromosome replication, the level of FtsZ decreases dramatically. This decrease is probably mostly due to the degradation of FtsZ in the swarmer compartment of the predivisional cell. Thus, the variation of FtsZ concentration parallels the pattern of DNA synthesis. Constitutive expression of FtsZ leads to defects in stalk biosynthesis suggesting a role for FtsZ in this developmental process in addition to its role in cell division.","number":"13","urldate":"2010-08-01TZ","journal":"Proceedings of the National Academy of Sciences of the United States of America","author":[{"propositions":[],"lastnames":["Quardokus"],"firstnames":["E"],"suffixes":[]},{"propositions":[],"lastnames":["Din"],"firstnames":["N"],"suffixes":[]},{"propositions":[],"lastnames":["Brun"],"firstnames":["Y","V"],"suffixes":[]}],"month":"June","year":"1996","pmid":"8692812","keywords":"Amino Acid Sequence, Bacterial Proteins, Caulobacter, Cell Cycle, Cloning, Molecular, Cytoskeletal Proteins, Escherichia coli, Molecular Sequence Data, Sequence Homology, Amino Acid","pages":"6314--6319","bibtex":"@article{quardokus_cell_1996,\n\ttitle = {Cell cycle regulation and cell type-specific localization of the {FtsZ} division initiation protein in {Caulobacter}},\n\tvolume = {93},\n\tissn = {0027-8424},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/8692812},\n\tabstract = {Many genes involved in cell division and DNA replication and their protein products have been identified in bacteria; however, little is known about the cell cycle regulation of the intracellular concentration of these proteins. 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