Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia across 5 countries in Asia. Quek, S. C., Lim, B. K., Domingo, E., Soon, R., Park, J. S., Vu, T. N., Tay, E. H., Le, Q. T., Kim, Y. T., Vu, B. Q., Cao, N. T., Limson, G., Pham, V. T., Molijn, A., Ramakrishnan, G., & Chen, J. International Journal of Gynecological Cancer, 23(1):148–156, 2013.
Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia across 5 countries in Asia [link]Paper  doi  abstract   bibtex   
Objective: Independent, prospective, multicenter, hospital-based cross-sectional studies were conducted across 5 countries in Asia, namely, Malaysia, Vietnam, Singapore, South Korea, and the Philippines. The objectives of these studies were to evaluate the prevalence of human papillomavirus (HPV) types (high risk and others including coinfections) in women with invasive cervical cancer (ICC) and high-grade precancerous lesions. Method(s): Women older than 21 years with a histologic diagnosis of ICC and cervical intraepithelial neoplasia [CIN 2 or 3 and adenocarcinoma in situ (AIS)] were enrolled. Cervical specimens were reviewed by histopathologists to confirm the presence of ICC or CIN 2/3/AIS lesion and tested with short PCR fragment10-DNA enzyme immunoassay-line probe assay for 14 oncogenic HPV types and 11 non-oncogenic HPV types. The prevalence of HPV 16, HPV 18, and other high-risk HPV types in ICC [including squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous carcinoma (ADC/ASC)] and CIN 2/3/AIS was estimated. Result(s): In the 5 Asian countries, diagnosis of ICC was confirmed in 500 women [SCC (n = 392) and ADC/ASC (n = 108)], and CIN 2/3/AIS, in 411 women. Human papillomavirus DNAwas detected in 93.8% to 97.0% (84.5% for the Philippines) of confirmed ICC cases [94.0%-98.7% of SCC; 87.0%-94.3% (50.0% for the Philippines) of ADC/ASC] and in 93.7% to 100.0% of CIN 2/3/AIS. The most common types observed among ICC cases were HPV16 (36.8%-61.3%), HPV18 (12.9%-35.4%), HPV52 (5.4%-10.3%), and HPV45 (1.5%-17.2%), whereas among CIN 2/3/AIS cases, HPV 16 (29.7%-46.6%) was the most commonly observed type followed by HPV 52 (17.0%-66.7%) and HPV 58 (8.6%-16.0%). Conclusion(s): This article presents the data on the HPV prevalence, HPV type distribution, and their role in cervical carcinogenesis in 5 Asian countries. These data are of relevance to public health authorities for evaluating the existing and future cervical cancer prevention strategies including HPV-DNA testing-based screening and HPV vaccination in these Asian populations. Copyright © 2013 by IGCS and ESGO.
@article{quek_human_2013,
	title = {Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia across 5 countries in {Asia}},
	volume = {23},
	issn = {1048-891X 1525-1438},
	url = {http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed14&NEWS=N&AN=368107715},
	doi = {10.1097/IGC.0b013e31827670fd},
	abstract = {Objective: Independent, prospective, multicenter, hospital-based cross-sectional studies were conducted across 5 countries in Asia, namely, Malaysia, Vietnam, Singapore, South Korea, and the Philippines. The objectives of these studies were to evaluate the prevalence of human papillomavirus (HPV) types (high risk and others including coinfections) in women with invasive cervical cancer (ICC) and high-grade precancerous lesions. Method(s): Women older than 21 years with a histologic diagnosis of ICC and cervical intraepithelial neoplasia [CIN 2 or 3 and adenocarcinoma in situ (AIS)] were enrolled. Cervical specimens were reviewed by histopathologists to confirm the presence of ICC or CIN 2/3/AIS lesion and tested with short PCR fragment10-DNA enzyme immunoassay-line probe assay for 14 oncogenic HPV types and 11 non-oncogenic HPV types. The prevalence of HPV 16, HPV 18, and other high-risk HPV types in ICC [including squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous carcinoma (ADC/ASC)] and CIN 2/3/AIS was estimated. Result(s): In the 5 Asian countries, diagnosis of ICC was confirmed in 500 women [SCC (n = 392) and ADC/ASC (n = 108)], and CIN 2/3/AIS, in 411 women. Human papillomavirus DNAwas detected in 93.8\% to 97.0\% (84.5\% for the Philippines) of confirmed ICC cases [94.0\%-98.7\% of SCC; 87.0\%-94.3\% (50.0\% for the Philippines) of ADC/ASC] and in 93.7\% to 100.0\% of CIN 2/3/AIS. The most common types observed among ICC cases were HPV16 (36.8\%-61.3\%), HPV18 (12.9\%-35.4\%), HPV52 (5.4\%-10.3\%), and HPV45 (1.5\%-17.2\%), whereas among CIN 2/3/AIS cases, HPV 16 (29.7\%-46.6\%) was the most commonly observed type followed by HPV 52 (17.0\%-66.7\%) and HPV 58 (8.6\%-16.0\%). Conclusion(s): This article presents the data on the HPV prevalence, HPV type distribution, and their role in cervical carcinogenesis in 5 Asian countries. These data are of relevance to public health authorities for evaluating the existing and future cervical cancer prevention strategies including HPV-DNA testing-based screening and HPV vaccination in these Asian populations. Copyright © 2013 by IGCS and ESGO.},
	language = {English},
	number = {1},
	journal = {International Journal of Gynecological Cancer},
	author = {Quek, S. C. and Lim, B. K. and Domingo, E. and Soon, R. and Park, J. S. and Vu, T. N. and Tay, E. H. and Le, Q. T. and Kim, Y. T. and Vu, B. Q. and Cao, N. T. and Limson, G. and Pham, V. T. and Molijn, A. and Ramakrishnan, G. and Chen, J.},
	year = {2013},
	keywords = {*Wart virus, *cervical adenocarcinoma/di [Diagnosis], *cervical adenocarcinoma/ep [Epidemiology], *invasive cervical cancer/di [Diagnosis], *invasive cervical cancer/ep [Epidemiology], *papillomavirus infection/ep [Epidemiology], *uterine cervix cancer/di [Diagnosis], *uterine cervix cancer/ep [Epidemiology], *uterine cervix carcinoma in situ/di [Diagnosis], *uterine cervix carcinoma in situ/ep [Epidemiology], *uterine cervix carcinoma/di [Diagnosis], *uterine cervix carcinoma/ep [Epidemiology], Asia, DNA fragment/ec [Endogenous Compound], DNA fragmentation, Human papillomavirus type 16, Human papillomavirus type 18, Malaysia, Philippines, Singapore, Viet Nam, adult, article, cancer diagnosis, cancer invasion, cancer patient, controlled study, cross-sectional study, diagnostic test accuracy study, disease association, disease severity, enzyme immunoassay, female, high risk patient, histopathology, human, major clinical study, multicenter study, pathologist, polymerase chain reaction, precancer, prevalence, priority journal, risk factor, sensitivity and specificity, uterine cervix, uterine cervix biopsy, virus DNA/ec [Endogenous Compound], virus strain},
	pages = {148--156}
}

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