Structural basis of mRNA cap recognition by proteins. Quiocho, F., A., Hu, G., & Gershon, P., D. Current opinion in structural biology, 10(1):78-86, 2, 2000. abstract bibtex Crystal structures have recently become available for two proteins (VP39 and eIF4E) complexed with their cognate ligand - the mRNA cap. Despite their total structural dissimilarity, both proteins bind N7-methylguanine between two parallel aromatic sidechains. The resulting stacked arrangement governs their high specificity for the alkylated form of the nucleobase.
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abstract = {Crystal structures have recently become available for two proteins (VP39 and eIF4E) complexed with their cognate ligand - the mRNA cap. Despite their total structural dissimilarity, both proteins bind N7-methylguanine between two parallel aromatic sidechains. The resulting stacked arrangement governs their high specificity for the alkylated form of the nucleobase.},
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author = {Quiocho, F A and Hu, G and Gershon, P D},
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