@article{quteineh_impact_2008,
	title = {Impact of {VKORC1} haplotypes on long-term graft function in kidney transplantation},
	volume = {86},
	issn = {1534-6080 (ELECTRONIC) 0041-1337 (LINKING)},
	shorttitle = {Impact of {VKORC1} haplotypes on long-term graft function in kidney transplantation},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/18813101},
	abstract = {BACKGROUND: Chronic allograft injury is the major cause of renal allograft loss after the first year of transplantation. Vitamin K epoxide reductase complex subunit 1 (VKORC1) haplotype combinations were found to be associated with the risk of developing vascular diseases. We aimed to study the effect of VKORC1 haplotypes on long-term graft function in a cohort of kidney transplant recipients. METHOD: A total of 288 renal allograft recipients participated in the study. Long-term renal graft function was measured by the estimation of the glomerular filtration rate. VKORC1 C+1173T single nucleotide polymorphism (rs9934438) was used as a tagging single nucleotide polymorphism for VKORC1*2 haplotype. RESULTS: Patients homozygous for VKORC1*2 haplotype showed less deterioration of renal graft function compared with the other patients (hazard ratio: 0.34, 95\% confidence interval: 0.26-0.87, P=0.02). The same results were obtained in a multivariate analysis, where VKORC1 haplotypes showed to be an independent predictor of long-term graft function when adjusted to other variables contributing to long-term renal graft outcome. CONCLUSION: Our results suggest that VKORC1 haplotypes may play a role in the long-term renal allograft function. These findings need to be replicated in prospective clinical studies.},
	number = {6},
	journal = {Transplantation},
	author = {Quteineh, L. and Verstuyft, C. and Durrbach, A. and Letierce, A. and Ferlicot, S. and Charpentier, B. and Becquemont, L.},
	month = sep,
	year = {2008},
	keywords = {Single Nucleotide Proportional Hazards Models Proteinuria Recurrence Retrospective Studies Survival Rate Treatment Outcome},
	pages = {779--83},
}

{"_id":"nEM8rZyE2ZFRzhqfA","bibbaseid":"quteineh-verstuyft-durrbach-letierce-ferlicot-charpentier-becquemont-impactofvkorc1haplotypesonlongtermgraftfunctioninkidneytransplantation-2008","author_short":["Quteineh, L.","Verstuyft, C.","Durrbach, A.","Letierce, A.","Ferlicot, S.","Charpentier, B.","Becquemont, L."],"bibdata":{"bibtype":"article","type":"article","title":"Impact of VKORC1 haplotypes on long-term graft function in kidney transplantation","volume":"86","issn":"1534-6080 (ELECTRONIC) 0041-1337 (LINKING)","shorttitle":"Impact of VKORC1 haplotypes on long-term graft function in kidney transplantation","url":"http://www.ncbi.nlm.nih.gov/pubmed/18813101","abstract":"BACKGROUND: Chronic allograft injury is the major cause of renal allograft loss after the first year of transplantation. Vitamin K epoxide reductase complex subunit 1 (VKORC1) haplotype combinations were found to be associated with the risk of developing vascular diseases. We aimed to study the effect of VKORC1 haplotypes on long-term graft function in a cohort of kidney transplant recipients. METHOD: A total of 288 renal allograft recipients participated in the study. Long-term renal graft function was measured by the estimation of the glomerular filtration rate. VKORC1 C+1173T single nucleotide polymorphism (rs9934438) was used as a tagging single nucleotide polymorphism for VKORC1*2 haplotype. RESULTS: Patients homozygous for VKORC1*2 haplotype showed less deterioration of renal graft function compared with the other patients (hazard ratio: 0.34, 95% confidence interval: 0.26-0.87, P=0.02). The same results were obtained in a multivariate analysis, where VKORC1 haplotypes showed to be an independent predictor of long-term graft function when adjusted to other variables contributing to long-term renal graft outcome. CONCLUSION: Our results suggest that VKORC1 haplotypes may play a role in the long-term renal allograft function. These findings need to be replicated in prospective clinical studies.","number":"6","journal":"Transplantation","author":[{"propositions":[],"lastnames":["Quteineh"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Verstuyft"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Durrbach"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Letierce"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Ferlicot"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Charpentier"],"firstnames":["B."],"suffixes":[]},{"propositions":[],"lastnames":["Becquemont"],"firstnames":["L."],"suffixes":[]}],"month":"September","year":"2008","keywords":"Single Nucleotide Proportional Hazards Models Proteinuria Recurrence Retrospective Studies Survival Rate Treatment Outcome","pages":"779–83","bibtex":"@article{quteineh_impact_2008,\n\ttitle = {Impact of {VKORC1} haplotypes on long-term graft function in kidney transplantation},\n\tvolume = {86},\n\tissn = {1534-6080 (ELECTRONIC) 0041-1337 (LINKING)},\n\tshorttitle = {Impact of {VKORC1} haplotypes on long-term graft function in kidney transplantation},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/18813101},\n\tabstract = {BACKGROUND: Chronic allograft injury is the major cause of renal allograft loss after the first year of transplantation. Vitamin K epoxide reductase complex subunit 1 (VKORC1) haplotype combinations were found to be associated with the risk of developing vascular diseases. We aimed to study the effect of VKORC1 haplotypes on long-term graft function in a cohort of kidney transplant recipients. METHOD: A total of 288 renal allograft recipients participated in the study. Long-term renal graft function was measured by the estimation of the glomerular filtration rate. VKORC1 C+1173T single nucleotide polymorphism (rs9934438) was used as a tagging single nucleotide polymorphism for VKORC1*2 haplotype. RESULTS: Patients homozygous for VKORC1*2 haplotype showed less deterioration of renal graft function compared with the other patients (hazard ratio: 0.34, 95\\% confidence interval: 0.26-0.87, P=0.02). The same results were obtained in a multivariate analysis, where VKORC1 haplotypes showed to be an independent predictor of long-term graft function when adjusted to other variables contributing to long-term renal graft outcome. CONCLUSION: Our results suggest that VKORC1 haplotypes may play a role in the long-term renal allograft function. These findings need to be replicated in prospective clinical studies.},\n\tnumber = {6},\n\tjournal = {Transplantation},\n\tauthor = {Quteineh, L. and Verstuyft, C. and Durrbach, A. and Letierce, A. and Ferlicot, S. and Charpentier, B. and Becquemont, L.},\n\tmonth = sep,\n\tyear = {2008},\n\tkeywords = {Single Nucleotide Proportional Hazards Models Proteinuria Recurrence Retrospective Studies Survival Rate Treatment Outcome},\n\tpages = {779--83},\n}\n\n","author_short":["Quteineh, L.","Verstuyft, C.","Durrbach, A.","Letierce, A.","Ferlicot, S.","Charpentier, B.","Becquemont, L."],"key":"quteineh_impact_2008","id":"quteineh_impact_2008","bibbaseid":"quteineh-verstuyft-durrbach-letierce-ferlicot-charpentier-becquemont-impactofvkorc1haplotypesonlongtermgraftfunctioninkidneytransplantation-2008","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/18813101"},"keyword":["Single Nucleotide Proportional Hazards Models Proteinuria Recurrence Retrospective Studies Survival Rate Treatment Outcome"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"http://bibbase.org/zotero/biblioial","dataSources":["ftoP3zPyb2N3b9Noc"],"keywords":["single nucleotide proportional hazards models proteinuria recurrence retrospective studies survival rate treatment outcome"],"search_terms":["impact","vkorc1","haplotypes","long","term","graft","function","kidney","transplantation","quteineh","verstuyft","durrbach","letierce","ferlicot","charpentier","becquemont"],"title":"Impact of VKORC1 haplotypes on long-term graft function in kidney transplantation","year":2008}