@article{rabe_combining_2022,
	title = {Combining metabolic phenotype determination with metabolomics and transcriptional analyses to reveal pathways regulated by hydroxycarboxylic acid receptor 2},
	volume = {13},
	issn = {2730-6011},
	url = {https://doi.org/10.1007/s12672-022-00503-3},
	doi = {10.1007/s12672-022-00503-3},
	abstract = {The adaptation of cellular metabolism is considered a hallmark of cancer. Oncogenic signaling pathways support tumorigenesis and cancer progression through the induction of certain metabolic phenotypes associated with altered regulation of key metabolic enzymes. Hydroxycarboxylic acid receptor 2 (HCA2) is a G protein-coupled receptor previously shown to act as a tumor suppressor. Here, we aimed to unveil the connection between cellular metabolism and HCA2 in BT-474 cells. Moreover, we intend to clarify how well this metabolic phenotype is reflected in transcriptional changes and metabolite levels as determined by global metabolomics analyses.},
	language = {en},
	number = {1},
	urldate = {2022-06-17},
	journal = {Discover Oncology},
	author = {Rabe, Philipp and Gehmlich, Mareike and Peters, Anna and Krumbholz, Petra and Nordström, Anders and Stäubert, Claudia},
	month = jun,
	year = {2022},
	keywords = {Cancer metabolism, GPR109A, HCA2, LC-MS, Metabolite profile, Metabolite-sensing GPCR},
	pages = {47},
}

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