A review of clinical pharmacogenetics studies in African populations

A review of clinical pharmacogenetics studies in African populations. Radouani, F., Zass, L., Hamdi, Y., da Rocha, J., Sallam, R., Abdelhak, S., Ahmed, S., Azzouzi, M., Benamri, I., Benkahla, A., Bouhaouala-Zahar, B., Chaouch, M., Jmel, H., Kefi, R., Ksouri, A., Kumuthini, J., Masilela, P., Masimirembwa, C., Othman, H., Panji, S., Romdhane, L., Samtal, C., Sibira, R., Ghedira, K., Fadlelmola, F., Kassim, S. K., & Mulder, N. Personalized Medicine, 17(2):155–170, Future Medicine Ltd London, UK, mar, 2020.

Paper doi abstract bibtex

Effective interventions and treatments for complex diseases have been implemented globally, however, coverage in Africa has been comparatively lower due to lack of capacity, clinical applicability and knowledge on the genetic contribution to disease and treatment. Currently, there is a scarcity of genetic data on African populations, which have enormous genetic diversity. Pharmacogenomics studies have the potential to revolutionise treatment of diseases, therefore, African populations are likely to benefit from these approaches to identify likely responders, reduce adverse side effects and optimise drug dosing. This review discusses clinical pharmacogenetics studies conducted in African populations, focusing on studies that examined drug response in complex diseases relevant to healthcare. Several pharmacogenetics associations have emerged from African studies, as have gaps in knowledge.

@article{Radouani2020,
abstract = {Effective interventions and treatments for complex diseases have been implemented globally, however, coverage in Africa has been comparatively lower due to lack of capacity, clinical applicability and knowledge on the genetic contribution to disease and treatment. Currently, there is a scarcity of genetic data on African populations, which have enormous genetic diversity. Pharmacogenomics studies have the potential to revolutionise treatment of diseases, therefore, African populations are likely to benefit from these approaches to identify likely responders, reduce adverse side effects and optimise drug dosing. This review discusses clinical pharmacogenetics studies conducted in African populations, focusing on studies that examined drug response in complex diseases relevant to healthcare. Several pharmacogenetics associations have emerged from African studies, as have gaps in knowledge.},
author = {Radouani, Fouzia and Zass, Lyndon and Hamdi, Yosr and da Rocha, Jorge and Sallam, Reem and Abdelhak, Sonia and Ahmed, Samah and Azzouzi, Maryame and Benamri, Ichrak and Benkahla, Alia and Bouhaouala-Zahar, Balkiss and Chaouch, Melek and Jmel, Haifa and Kefi, Rym and Ksouri, Ayoub and Kumuthini, Judit and Masilela, Phumlani and Masimirembwa, Collen and Othman, Houcemeddine and Panji, Sumir and Romdhane, Lilia and Samtal, Chaimae and Sibira, Rania and Ghedira, Kais and Fadlelmola, Faisal and Kassim, Samar Kamal and Mulder, Nicola},
doi = {10.2217/pme-2019-0110},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Radouani et al. - 2020 - A review of clinical pharmacogenetics studies in African populations.pdf:pdf},
issn = {1741-0541},
journal = {Personalized Medicine},
keywords = {Africa,OA,communicable diseases,fund{\_}not{\_}ack,genetic variation,noncommunicable diseases,pharmacogenetics,pharmacogenomics,precision medicine,review},
mendeley-tags = {OA,fund{\_}not{\_}ack,review},
month = {mar},
number = {2},
pages = {155--170},
pmid = {32125935},
publisher = {Future Medicine Ltd London, UK},
title = {{A review of clinical pharmacogenetics studies in African populations}},
url = {https://www.futuremedicine.com/doi/10.2217/pme-2019-0110},
volume = {17},
year = {2020}
}

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