A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps. Radua, J., Mataix-Cols, D., Phillips, M. L., El-Hage, W., Kronhaus, D. M., Cardoner, N., & Surguladze, S. European Psychiatry: The Journal of the Association of European Psychiatrists, 27(8):605--611, November, 2012.
doi  abstract   bibtex   
Meta-analyses are essential to summarize the results of the growing number of neuroimaging studies in psychiatry, neurology and allied disciplines. Image-based meta-analyses use full image information (i.e. the statistical parametric maps) and well-established statistics, but images are rarely available making them highly unfeasible. Peak-probability meta-analyses such as activation likelihood estimation (ALE) or multilevel kernel density analysis (MKDA) are more feasible as they only need reported peak coordinates. Signed-differences methods, such as signed differential mapping (SDM) build upon the positive features of existing peak-probability methods and enable meta-analyses of studies comparing patients with controls. In this paper we present a new version of SDM, named Effect Size SDM (ES-SDM), which enables the combination of statistical parametric maps and peak coordinates and uses well-established statistics. We validated the new method by comparing the results of an ES-SDM meta-analysis of studies on the brain response to fearful faces with the results of a pooled analysis of the original individual data. The results showed that ES-SDM is a valid and reliable coordinate-based method, whose performance might be additionally increased by including statistical parametric maps. We anticipate that ES-SDM will be a helpful tool for researchers in the fields of psychiatry, neurology and allied disciplines.
@article{ radua_new_2012,
  title = {A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps},
  volume = {27},
  issn = {1778-3585},
  doi = {10.1016/j.eurpsy.2011.04.001},
  abstract = {Meta-analyses are essential to summarize the results of the growing number of neuroimaging studies in psychiatry, neurology and allied disciplines. Image-based meta-analyses use full image information (i.e. the statistical parametric maps) and well-established statistics, but images are rarely available making them highly unfeasible. Peak-probability meta-analyses such as activation likelihood estimation (ALE) or multilevel kernel density analysis (MKDA) are more feasible as they only need reported peak coordinates. Signed-differences methods, such as signed differential mapping (SDM) build upon the positive features of existing peak-probability methods and enable meta-analyses of studies comparing patients with controls. In this paper we present a new version of SDM, named Effect Size SDM (ES-SDM), which enables the combination of statistical parametric maps and peak coordinates and uses well-established statistics. We validated the new method by comparing the results of an ES-SDM meta-analysis of studies on the brain response to fearful faces with the results of a pooled analysis of the original individual data. The results showed that ES-SDM is a valid and reliable coordinate-based method, whose performance might be additionally increased by including statistical parametric maps. We anticipate that ES-SDM will be a helpful tool for researchers in the fields of psychiatry, neurology and allied disciplines.},
  language = {eng},
  number = {8},
  journal = {European Psychiatry: The Journal of the Association of European Psychiatrists},
  author = {Radua, J. and Mataix-Cols, D. and Phillips, M. L. and El-Hage, W. and Kronhaus, D. M. and Cardoner, N. and Surguladze, S.},
  month = {November},
  year = {2012},
  pmid = {21658917},
  keywords = {Adult, Brain, Brain Mapping, Facial Expression, Humans, Magnetic Resonance Imaging, Neuroimaging, Neuropsychological Tests, Reproducibility of Results},
  pages = {605--611}
}

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