@ARTICLE{Ramos2015-sa,
  title    = "The long noncoding {RNA} Pnky regulates neuronal differentiation
              of embryonic and postnatal neural stem cells",
  author   = "Ramos, Alexander D and Andersen, Rebecca E and Liu, Siyuan John
              and Nowakowski, Tomasz Jan and Hong, Sung Jun and Gertz, Caitlyn
              and Salinas, Ryan D and Zarabi, Hosniya and Kriegstein, Arnold R
              and Lim, Daniel A",
  abstract = "While thousands of long noncoding RNAs (lncRNAs) have been
              identified, few lncRNAs that control neural stem cell (NSC)
              behavior are known. Here, we identify Pinky (Pnky) as a
              neural-specific lncRNA that regulates neurogenesis from NSCs in
              the embryonic and postnatal brain. In postnatal NSCs, Pnky
              knockdown potentiates neuronal lineage commitment and expands the
              transit-amplifying cell population, increasing neuron production
              several-fold. Pnky is evolutionarily conserved and expressed in
              NSCs of the developing human brain. In the embryonic mouse
              cortex, Pnky knockdown increases neuronal differentiation and
              depletes the NSC population. Pnky interacts with the splicing
              regulator PTBP1, and PTBP1 knockdown also enhances neurogenesis.
              In NSCs, Pnky and PTBP1 regulate the expression and alternative
              splicing of a core set of transcripts that relates to the
              cellular phenotype. These data thus unveil Pnky as a conserved
              lncRNA that interacts with a key RNA processing factor and
              regulates neurogenesis from embryonic and postnatal NSC
              populations.",
  journal  = "Cell Stem Cell",
  volume   =  16,
  number   =  4,
  pages    = "439--447",
  month    =  mar,
  year     =  2015,
  language = "en"
}

{"_id":"e69XH5xeCh5SnnJFj","bibbaseid":"ramos-andersen-liu-nowakowski-hong-gertz-salinas-zarabi-etal-thelongnoncodingrnapnkyregulatesneuronaldifferentiationofembryonicandpostnatalneuralstemcells-2015","author_short":["Ramos, A. D","Andersen, R. E","Liu, S. J.","Nowakowski, T. J.","Hong, S. J.","Gertz, C.","Salinas, R. D","Zarabi, H.","Kriegstein, A. R","Lim, D. A"],"bibdata":{"bibtype":"article","type":"article","title":"The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells","author":[{"propositions":[],"lastnames":["Ramos"],"firstnames":["Alexander","D"],"suffixes":[]},{"propositions":[],"lastnames":["Andersen"],"firstnames":["Rebecca","E"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Siyuan","John"],"suffixes":[]},{"propositions":[],"lastnames":["Nowakowski"],"firstnames":["Tomasz","Jan"],"suffixes":[]},{"propositions":[],"lastnames":["Hong"],"firstnames":["Sung","Jun"],"suffixes":[]},{"propositions":[],"lastnames":["Gertz"],"firstnames":["Caitlyn"],"suffixes":[]},{"propositions":[],"lastnames":["Salinas"],"firstnames":["Ryan","D"],"suffixes":[]},{"propositions":[],"lastnames":["Zarabi"],"firstnames":["Hosniya"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]},{"propositions":[],"lastnames":["Lim"],"firstnames":["Daniel","A"],"suffixes":[]}],"abstract":"While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a neural-specific lncRNA that regulates neurogenesis from NSCs in the embryonic and postnatal brain. In postnatal NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying cell population, increasing neuron production several-fold. Pnky is evolutionarily conserved and expressed in NSCs of the developing human brain. In the embryonic mouse cortex, Pnky knockdown increases neuronal differentiation and depletes the NSC population. Pnky interacts with the splicing regulator PTBP1, and PTBP1 knockdown also enhances neurogenesis. In NSCs, Pnky and PTBP1 regulate the expression and alternative splicing of a core set of transcripts that relates to the cellular phenotype. These data thus unveil Pnky as a conserved lncRNA that interacts with a key RNA processing factor and regulates neurogenesis from embryonic and postnatal NSC populations.","journal":"Cell Stem Cell","volume":"16","number":"4","pages":"439–447","month":"March","year":"2015","language":"en","bibtex":"@ARTICLE{Ramos2015-sa,\n title = \"The long noncoding {RNA} Pnky regulates neuronal differentiation\n of embryonic and postnatal neural stem cells\",\n author = \"Ramos, Alexander D and Andersen, Rebecca E and Liu, Siyuan John\n and Nowakowski, Tomasz Jan and Hong, Sung Jun and Gertz, Caitlyn\n and Salinas, Ryan D and Zarabi, Hosniya and Kriegstein, Arnold R\n and Lim, Daniel A\",\n abstract = \"While thousands of long noncoding RNAs (lncRNAs) have been\n identified, few lncRNAs that control neural stem cell (NSC)\n behavior are known. Here, we identify Pinky (Pnky) as a\n neural-specific lncRNA that regulates neurogenesis from NSCs in\n the embryonic and postnatal brain. In postnatal NSCs, Pnky\n knockdown potentiates neuronal lineage commitment and expands the\n transit-amplifying cell population, increasing neuron production\n several-fold. Pnky is evolutionarily conserved and expressed in\n NSCs of the developing human brain. In the embryonic mouse\n cortex, Pnky knockdown increases neuronal differentiation and\n depletes the NSC population. Pnky interacts with the splicing\n regulator PTBP1, and PTBP1 knockdown also enhances neurogenesis.\n In NSCs, Pnky and PTBP1 regulate the expression and alternative\n splicing of a core set of transcripts that relates to the\n cellular phenotype. These data thus unveil Pnky as a conserved\n lncRNA that interacts with a key RNA processing factor and\n regulates neurogenesis from embryonic and postnatal NSC\n populations.\",\n journal = \"Cell Stem Cell\",\n volume = 16,\n number = 4,\n pages = \"439--447\",\n month = mar,\n year = 2015,\n language = \"en\"\n}\n\n","author_short":["Ramos, A. D","Andersen, R. E","Liu, S. J.","Nowakowski, T. J.","Hong, S. J.","Gertz, C.","Salinas, R. D","Zarabi, H.","Kriegstein, A. R","Lim, D. A"],"key":"Ramos2015-sa","id":"Ramos2015-sa","bibbaseid":"ramos-andersen-liu-nowakowski-hong-gertz-salinas-zarabi-etal-thelongnoncodingrnapnkyregulatesneuronaldifferentiationofembryonicandpostnatalneuralstemcells-2015","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["long","noncoding","rna","pnky","regulates","neuronal","differentiation","embryonic","postnatal","neural","stem","cells","ramos","andersen","liu","nowakowski","hong","gertz","salinas","zarabi","kriegstein","lim"],"title":"The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells","year":2015}