A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA

A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA. Rani, N., Nowakowski, T. J, Zhou, H., Godshalk, S. E, Lisi, V., Kriegstein, A. R, & Kosik, K. S Neuron, 90(6):1174–1188, June, 2016.
abstract bibtex

Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, particularly in the brain. We identified an lncRNA, which has acquired 16 microRNA response elements for miR-143-3p in the Catarrhini branch of primates. This lncRNA, termed LncND (neurodevelopment), is expressed in neural progenitor cells and then declines in neurons. Binding and release of miR-143-3p by LncND control the expression of Notch receptors. LncND expression is enriched in radial glia cells (RGCs) in the ventricular and subventricular zones of developing human brain. Downregulation in neuroblastoma cells reduced cell proliferation and induced neuronal differentiation, an effect phenocopied by miR-143-3p overexpression. Gain of function of LncND in developing mouse cortex led to an expansion of PAX6+ RGCs. These findings support a role for LncND in miRNA-mediated regulation of Notch signaling within the neural progenitor pool in primates that may have contributed to the expansion of cerebral cortex.

@ARTICLE{Rani2016-zn,
  title    = "A Primate {lncRNA} Mediates Notch Signaling during Neuronal
              Development by Sequestering {miRNA}",
  author   = "Rani, Neha and Nowakowski, Tomasz J and Zhou, Hongjun and
              Godshalk, Sirie E and Lisi, V{\'e}ronique and Kriegstein, Arnold
              R and Kosik, Kenneth S",
  abstract = "Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved
              category of transcripts that have expanded greatly in primates,
              particularly in the brain. We identified an lncRNA, which has
              acquired 16 microRNA response elements for miR-143-3p in the
              Catarrhini branch of primates. This lncRNA, termed LncND
              (neurodevelopment), is expressed in neural progenitor cells and
              then declines in neurons. Binding and release of miR-143-3p by
              LncND control the expression of Notch receptors. LncND expression
              is enriched in radial glia cells (RGCs) in the ventricular and
              subventricular zones of developing human brain. Downregulation in
              neuroblastoma cells reduced cell proliferation and induced
              neuronal differentiation, an effect phenocopied by miR-143-3p
              overexpression. Gain of function of LncND in developing mouse
              cortex led to an expansion of PAX6+ RGCs. These findings support
              a role for LncND in miRNA-mediated regulation of Notch signaling
              within the neural progenitor pool in primates that may have
              contributed to the expansion of cerebral cortex.",
  journal  = "Neuron",
  volume   =  90,
  number   =  6,
  pages    = "1174--1188",
  month    =  jun,
  year     =  2016,
  language = "en"
}

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