The relationship between basal cell epithelioma and seborrheic keratosis. A study of 60 cases. Rao, B. K., Freeman, R. G., Poulos, E. G., Arbesfeld, L., & Rendon, M. J Dermatol Surg Oncol, 20(11):761–4, November, 1994. Paper doi abstract bibtex BACKGROUND: Various skin tumors can be seen rarely in association with seborrheic keratosis. We present 60 cases of seborrheic keratosis related to a basal cell epithelioma in the same specimen. OBJECTIVE: To report association of basal cell epithelioma with seborrheic keratosis and discuss the possibility of malignant change in seborrheic keratosis. METHODS: Sixty cases of seborrheic keratosis associated with basal cell epithelioma were studied. Tissues were fixed in neutral buffered formalin, processed, and stained with standard hematoxylin and eosin techniques. RESULTS: Histological evaluation showed a seborrheic keratosis associated with basal cell epithelioma in all of the cases. Basal cell epithelioma was attached with seborrheic keratosis in a majority of the cases (40/60) and appeared to represent a part of the same tumor. Both tumors were lying adjacent to each other in the rest of the cases (20/60). CONCLUSION: Malignant change in seborrheic keratosis is controversial. We recommend the histological evaluation of seborrheic keratosis especially when inflamed or atypical in appearance. This should not be taken as a mandate for pathological evaluation or for treatment of every seborrheic keratosis as though it was potentially malignant.
@article{rao_relationship_1994,
title = {The relationship between basal cell epithelioma and seborrheic keratosis. {A} study of 60 cases},
volume = {20},
copyright = {All rights reserved},
issn = {0148-0812 (Print) 0148-0812 (Linking)},
url = {https://www.ncbi.nlm.nih.gov/pubmed/7962939},
doi = {10.1111/j.1524-4725.1994.tb03201.x},
abstract = {BACKGROUND: Various skin tumors can be seen rarely in association with seborrheic keratosis. We present 60 cases of seborrheic keratosis related to a basal cell epithelioma in the same specimen. OBJECTIVE: To report association of basal cell epithelioma with seborrheic keratosis and discuss the possibility of malignant change in seborrheic keratosis. METHODS: Sixty cases of seborrheic keratosis associated with basal cell epithelioma were studied. Tissues were fixed in neutral buffered formalin, processed, and stained with standard hematoxylin and eosin techniques. RESULTS: Histological evaluation showed a seborrheic keratosis associated with basal cell epithelioma in all of the cases. Basal cell epithelioma was attached with seborrheic keratosis in a majority of the cases (40/60) and appeared to represent a part of the same tumor. Both tumors were lying adjacent to each other in the rest of the cases (20/60). CONCLUSION: Malignant change in seborrheic keratosis is controversial. We recommend the histological evaluation of seborrheic keratosis especially when inflamed or atypical in appearance. This should not be taken as a mandate for pathological evaluation or for treatment of every seborrheic keratosis as though it was potentially malignant.},
number = {11},
journal = {J Dermatol Surg Oncol},
author = {Rao, B. K. and Freeman, R. G. and Poulos, E. G. and Arbesfeld, L. and Rendon, M.},
month = nov,
year = {1994},
keywords = {Adult, Aged, Aged, 80 and over, Carcinoma, Basal Cell/*complications/pathology, Cell Transformation, Neoplastic, Female, Humans, Keratosis, Seborrheic/*complications/pathology, Male, Middle Aged, Skin Neoplasms/*complications/pathology},
pages = {761--4},
}
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METHODS: Sixty cases of seborrheic keratosis associated with basal cell epithelioma were studied. Tissues were fixed in neutral buffered formalin, processed, and stained with standard hematoxylin and eosin techniques. RESULTS: Histological evaluation showed a seborrheic keratosis associated with basal cell epithelioma in all of the cases. Basal cell epithelioma was attached with seborrheic keratosis in a majority of the cases (40/60) and appeared to represent a part of the same tumor. Both tumors were lying adjacent to each other in the rest of the cases (20/60). CONCLUSION: Malignant change in seborrheic keratosis is controversial. We recommend the histological evaluation of seborrheic keratosis especially when inflamed or atypical in appearance. This should not be taken as a mandate for pathological evaluation or for treatment of every seborrheic keratosis as though it was potentially malignant.","number":"11","journal":"J Dermatol Surg Oncol","author":[{"propositions":[],"lastnames":["Rao"],"firstnames":["B.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Freeman"],"firstnames":["R.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Poulos"],"firstnames":["E.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Arbesfeld"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Rendon"],"firstnames":["M."],"suffixes":[]}],"month":"November","year":"1994","keywords":"Adult, Aged, Aged, 80 and over, Carcinoma, Basal Cell/*complications/pathology, Cell Transformation, Neoplastic, Female, Humans, Keratosis, Seborrheic/*complications/pathology, Male, Middle Aged, Skin Neoplasms/*complications/pathology","pages":"761–4","bibtex":"@article{rao_relationship_1994,\n\ttitle = {The relationship between basal cell epithelioma and seborrheic keratosis. {A} study of 60 cases},\n\tvolume = {20},\n\tcopyright = {All rights reserved},\n\tissn = {0148-0812 (Print) 0148-0812 (Linking)},\n\turl = {https://www.ncbi.nlm.nih.gov/pubmed/7962939},\n\tdoi = {10.1111/j.1524-4725.1994.tb03201.x},\n\tabstract = {BACKGROUND: Various skin tumors can be seen rarely in association with seborrheic keratosis. We present 60 cases of seborrheic keratosis related to a basal cell epithelioma in the same specimen. OBJECTIVE: To report association of basal cell epithelioma with seborrheic keratosis and discuss the possibility of malignant change in seborrheic keratosis. METHODS: Sixty cases of seborrheic keratosis associated with basal cell epithelioma were studied. Tissues were fixed in neutral buffered formalin, processed, and stained with standard hematoxylin and eosin techniques. RESULTS: Histological evaluation showed a seborrheic keratosis associated with basal cell epithelioma in all of the cases. Basal cell epithelioma was attached with seborrheic keratosis in a majority of the cases (40/60) and appeared to represent a part of the same tumor. Both tumors were lying adjacent to each other in the rest of the cases (20/60). CONCLUSION: Malignant change in seborrheic keratosis is controversial. 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