Ancient human genome sequence of an extinct Palaeo-Eskimo. Rasmussen, M., Li, Y., Lindgreen, S., Pedersen, J., S., Albrechtsen, A., Moltke, I., Metspalu, M., Metspalu, E., Kivisild, T., Gupta, R., Bertalan, M., Nielsen, K., Gilbert, M., T., Wang, Y., Raghavan, M., Campos, P., F., Kamp, H., M., Wilson, A., S., Gledhill, A., Tridico, S., Bunce, M., Lorenzen, E., D., Binladen, J., Guo, X., Zhao, J., Zhang, X., Zhang, H., Li, Z., Chen, M., Orlando, L., Kristiansen, K., Bak, M., Tommerup, N., Bendixen, C., Pierre, T., L., Gronnow, B., Meldgaard, M., Andreasen, C., Fedorova, S., A., Osipova, L., P., Higham, T., F., Ramsey, C., B., Hansen, T., V., Nielsen, F., C., Crawford, M., H., Brunak, S., Sicheritz-Ponten, T., Villems, R., Nielsen, R., Krogh, A., Wang, J., & Willerslev, E. Nature, 463(7282):757-762, Nature Publishing Group, 2, 2010.
![Ancient human genome sequence of an extinct Palaeo-Eskimo [pdf]](https://bibbase.org/img/filetypes/pdf.svg "pdf")
Paper ![Ancient human genome sequence of an extinct Palaeo-Eskimo [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex
Paper Website abstract bibtex We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.
@article{
title = {Ancient human genome sequence of an extinct Palaeo-Eskimo},
type = {article},
year = {2010},
identifiers = {[object Object]},
keywords = {*Cryopreservation,*Extinction,Ancient,Biological,DNA,Emigration and Immigration/history,Genetics,Genome,Genomics,Genotype,Greenland,Hair,History,Human/*genetics,Humans,Inuits/*genetics,Male,Phenotype,Phylogeny,Polymorphism,Population,Sequence Analysis,Siberia/ethnology,Single Nucleotide/genetics},
pages = {757-762},
volume = {463},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/20148029},
month = {2},
publisher = {Nature Publishing Group},
day = {11},
id = {060daa70-995e-34e1-bd6b-11e762367ce7},
created = {2015-12-15T10:33:32.000Z},
accessed = {2013-12-12},
file_attached = {true},
profile_id = {be57537b-17b1-39be-b233-ed67db2cc4b7},
last_modified = {2017-03-15T00:24:05.134Z},
read = {true},
starred = {false},
authored = {true},
confirmed = {true},
hidden = {false},
citation_key = {Rasmussen2010},
source_type = {JOUR},
folder_uuids = {07308178-ea07-4b21-b718-b83cdc9ecb43,b70a4f98-1546-4259-afbd-d9a8fe296e69,f7245de5-b312-4a59-ab6d-2dfb4344df71,e0d742db-83ed-4925-85ba-c0344307eca4},
abstract = {We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.},
bibtype = {article},
author = {Rasmussen, M and Li, Y and Lindgreen, S and Pedersen, J S and Albrechtsen, A and Moltke, I and Metspalu, M and Metspalu, E and Kivisild, T and Gupta, R and Bertalan, M and Nielsen, K and Gilbert, M T and Wang, Y and Raghavan, M and Campos, P F and Kamp, H M and Wilson, A S and Gledhill, A and Tridico, S and Bunce, M and Lorenzen, E D and Binladen, J and Guo, X and Zhao, J and Zhang, X and Zhang, H and Li, Z and Chen, M and Orlando, L and Kristiansen, K and Bak, M and Tommerup, N and Bendixen, C and Pierre, T L and Gronnow, B and Meldgaard, M and Andreasen, C and Fedorova, S A and Osipova, L P and Higham, T F and Ramsey, C B and Hansen, T V and Nielsen, F C and Crawford, M H and Brunak, S and Sicheritz-Ponten, T and Villems, R and Nielsen, R and Krogh, A and Wang, J and Willerslev, E},
journal = {Nature},
number = {7282}
}Downloads: 0
{"_id":"6F5SEuvQXvHdMZkXL","bibbaseid":"rasmussen-li-lindgreen-pedersen-albrechtsen-moltke-metspalu-metspalu-etal-ancienthumangenomesequenceofanextinctpalaeoeskimo-2010","downloads":0,"creationDate":"2017-06-13T11:23:24.524Z","title":"Ancient human genome sequence of an extinct Palaeo-Eskimo","author_short":["Rasmussen, M.","Li, Y.","Lindgreen, S.","Pedersen, J., S.","Albrechtsen, A.","Moltke, I.","Metspalu, M.","Metspalu, E.","Kivisild, T.","Gupta, R.","Bertalan, M.","Nielsen, K.","Gilbert, M., T.","Wang, Y.","Raghavan, M.","Campos, P., F.","Kamp, H., M.","Wilson, A., S.","Gledhill, A.","Tridico, S.","Bunce, M.","Lorenzen, E., D.","Binladen, J.","Guo, X.","Zhao, J.","Zhang, X.","Zhang, H.","Li, Z.","Chen, M.","Orlando, L.","Kristiansen, K.","Bak, M.","Tommerup, N.","Bendixen, C.","Pierre, T., L.","Gronnow, B.","Meldgaard, M.","Andreasen, C.","Fedorova, S., A.","Osipova, L., P.","Higham, T., F.","Ramsey, C., B.","Hansen, T., V.","Nielsen, F., C.","Crawford, M., H.","Brunak, S.","Sicheritz-Ponten, T.","Villems, R.","Nielsen, R.","Krogh, A.","Wang, J.","Willerslev, E."],"year":2010,"bibtype":"article","biburl":null,"bibdata":{"title":"Ancient human genome sequence of an extinct Palaeo-Eskimo","type":"article","year":"2010","identifiers":"[object Object]","keywords":"*Cryopreservation,*Extinction,Ancient,Biological,DNA,Emigration and Immigration/history,Genetics,Genome,Genomics,Genotype,Greenland,Hair,History,Human/*genetics,Humans,Inuits/*genetics,Male,Phenotype,Phylogeny,Polymorphism,Population,Sequence Analysis,Siberia/ethnology,Single Nucleotide/genetics","pages":"757-762","volume":"463","websites":"http://www.ncbi.nlm.nih.gov/pubmed/20148029","month":"2","publisher":"Nature Publishing Group","day":"11","id":"060daa70-995e-34e1-bd6b-11e762367ce7","created":"2015-12-15T10:33:32.000Z","accessed":"2013-12-12","file_attached":"true","profile_id":"be57537b-17b1-39be-b233-ed67db2cc4b7","last_modified":"2017-03-15T00:24:05.134Z","read":"true","starred":false,"authored":"true","confirmed":"true","hidden":false,"citation_key":"Rasmussen2010","source_type":"JOUR","folder_uuids":"07308178-ea07-4b21-b718-b83cdc9ecb43,b70a4f98-1546-4259-afbd-d9a8fe296e69,f7245de5-b312-4a59-ab6d-2dfb4344df71,e0d742db-83ed-4925-85ba-c0344307eca4","abstract":"We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.","bibtype":"article","author":"Rasmussen, M and Li, Y and Lindgreen, S and Pedersen, J S and Albrechtsen, A and Moltke, I and Metspalu, M and Metspalu, E and Kivisild, T and Gupta, R and Bertalan, M and Nielsen, K and Gilbert, M T and Wang, Y and Raghavan, M and Campos, P F and Kamp, H M and Wilson, A S and Gledhill, A and Tridico, S and Bunce, M and Lorenzen, E D and Binladen, J and Guo, X and Zhao, J and Zhang, X and Zhang, H and Li, Z and Chen, M and Orlando, L and Kristiansen, K and Bak, M and Tommerup, N and Bendixen, C and Pierre, T L and Gronnow, B and Meldgaard, M and Andreasen, C and Fedorova, S A and Osipova, L P and Higham, T F and Ramsey, C B and Hansen, T V and Nielsen, F C and Crawford, M H and Brunak, S and Sicheritz-Ponten, T and Villems, R and Nielsen, R and Krogh, A and Wang, J and Willerslev, E","journal":"Nature","number":"7282","bibtex":"@article{\n title = {Ancient human genome sequence of an extinct Palaeo-Eskimo},\n type = {article},\n year = {2010},\n identifiers = {[object Object]},\n keywords = {*Cryopreservation,*Extinction,Ancient,Biological,DNA,Emigration and Immigration/history,Genetics,Genome,Genomics,Genotype,Greenland,Hair,History,Human/*genetics,Humans,Inuits/*genetics,Male,Phenotype,Phylogeny,Polymorphism,Population,Sequence Analysis,Siberia/ethnology,Single Nucleotide/genetics},\n pages = {757-762},\n volume = {463},\n websites = {http://www.ncbi.nlm.nih.gov/pubmed/20148029},\n month = {2},\n publisher = {Nature Publishing Group},\n day = {11},\n id = {060daa70-995e-34e1-bd6b-11e762367ce7},\n created = {2015-12-15T10:33:32.000Z},\n accessed = {2013-12-12},\n file_attached = {true},\n profile_id = {be57537b-17b1-39be-b233-ed67db2cc4b7},\n last_modified = {2017-03-15T00:24:05.134Z},\n read = {true},\n starred = {false},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n citation_key = {Rasmussen2010},\n source_type = {JOUR},\n folder_uuids = {07308178-ea07-4b21-b718-b83cdc9ecb43,b70a4f98-1546-4259-afbd-d9a8fe296e69,f7245de5-b312-4a59-ab6d-2dfb4344df71,e0d742db-83ed-4925-85ba-c0344307eca4},\n abstract = {We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.},\n bibtype = {article},\n author = {Rasmussen, M and Li, Y and Lindgreen, S and Pedersen, J S and Albrechtsen, A and Moltke, I and Metspalu, M and Metspalu, E and Kivisild, T and Gupta, R and Bertalan, M and Nielsen, K and Gilbert, M T and Wang, Y and Raghavan, M and Campos, P F and Kamp, H M and Wilson, A S and Gledhill, A and Tridico, S and Bunce, M and Lorenzen, E D and Binladen, J and Guo, X and Zhao, J and Zhang, X and Zhang, H and Li, Z and Chen, M and Orlando, L and Kristiansen, K and Bak, M and Tommerup, N and Bendixen, C and Pierre, T L and Gronnow, B and Meldgaard, M and Andreasen, C and Fedorova, S A and Osipova, L P and Higham, T F and Ramsey, C B and Hansen, T V and Nielsen, F C and Crawford, M H and Brunak, S and Sicheritz-Ponten, T and Villems, R and Nielsen, R and Krogh, A and Wang, J and Willerslev, E},\n journal = {Nature},\n number = {7282}\n}","author_short":["Rasmussen, M.","Li, Y.","Lindgreen, S.","Pedersen, J., S.","Albrechtsen, A.","Moltke, I.","Metspalu, M.","Metspalu, E.","Kivisild, T.","Gupta, R.","Bertalan, M.","Nielsen, K.","Gilbert, M., T.","Wang, Y.","Raghavan, M.","Campos, P., F.","Kamp, H., M.","Wilson, A., S.","Gledhill, A.","Tridico, S.","Bunce, M.","Lorenzen, E., D.","Binladen, J.","Guo, X.","Zhao, J.","Zhang, X.","Zhang, H.","Li, Z.","Chen, M.","Orlando, L.","Kristiansen, K.","Bak, M.","Tommerup, N.","Bendixen, C.","Pierre, T., L.","Gronnow, B.","Meldgaard, M.","Andreasen, C.","Fedorova, S., A.","Osipova, L., P.","Higham, T., F.","Ramsey, C., B.","Hansen, T., V.","Nielsen, F., C.","Crawford, M., H.","Brunak, S.","Sicheritz-Ponten, T.","Villems, R.","Nielsen, R.","Krogh, A.","Wang, J.","Willerslev, E."],"urls":{"Paper":"http://bibbase.org/service/mendeley/be57537b-17b1-39be-b233-ed67db2cc4b7/file/619947f5-bad6-d5d3-48de-f03f4f8fce4e/2010-Ancient_human_genome_sequence_of_an_extinct_Palaeo-Eskimo.pdf.pdf","Website":"http://www.ncbi.nlm.nih.gov/pubmed/20148029"},"bibbaseid":"rasmussen-li-lindgreen-pedersen-albrechtsen-moltke-metspalu-metspalu-etal-ancienthumangenomesequenceofanextinctpalaeoeskimo-2010","role":"author","keyword":["*Cryopreservation","*Extinction","Ancient","Biological","DNA","Emigration and Immigration/history","Genetics","Genome","Genomics","Genotype","Greenland","Hair","History","Human/*genetics","Humans","Inuits/*genetics","Male","Phenotype","Phylogeny","Polymorphism","Population","Sequence Analysis","Siberia/ethnology","Single Nucleotide/genetics"],"downloads":0},"search_terms":["ancient","human","genome","sequence","extinct","palaeo","eskimo","rasmussen","li","lindgreen","pedersen","albrechtsen","moltke","metspalu","metspalu","kivisild","gupta","bertalan","nielsen","gilbert","wang","raghavan","campos","kamp","wilson","gledhill","tridico","bunce","lorenzen","binladen","guo","zhao","zhang","zhang","li","chen","orlando","kristiansen","bak","tommerup","bendixen","pierre","gronnow","meldgaard","andreasen","fedorova","osipova","higham","ramsey","hansen","nielsen","crawford","brunak","sicheritz-ponten","villems","nielsen","krogh","wang","willerslev"],"keywords":["*cryopreservation","*extinction","ancient","biological","dna","emigration and immigration/history","genetics","genome","genomics","genotype","greenland","hair","history","human/*genetics","humans","inuits/*genetics","male","phenotype","phylogeny","polymorphism","population","sequence analysis","siberia/ethnology","single nucleotide/genetics"],"authorIDs":[]}