Liver volatolomics to reveal poultry exposure to γ-hexabromocyclododecane (HBCD)

Liver volatolomics to reveal poultry exposure to γ-hexabromocyclododecane (HBCD). Ratel, J., Planche, C., Mercier, F., Blinet, P., Kondjoyan, N., Marchand, P., Fournier, A., Travel, A., Jondreville, C., & Engel, E. 189:634–642.

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Hexabromocyclododecane (HBCD) is a critical emerging brominated ﬂame retardant to which consumers can be exposed at high doses through a single food intake. Based on an animal experiment involving 3 groups of laying hens fed during 70 days with a control diet or g-HBCD-contaminated diets at 0.1 or 10 mg g-HBCD gÀ1 feed, this study aims to use the volatolome of biological samples for revealing markers of livestock exposure to HBCD. Liquid chromatographyetandem mass spectrometry was used to monitor the time-course of HBCD levels in bodily samples. Each liver was analyzed by solid-phase microextractionegas chromatographyemass spectrometry for volatolome proﬁling. After 70 days, g-HBCD concentrations in egg yolk, fat, liver and serum reached 54 ± 4, 85 ± 6, 31 ± 6, and 32 ± 4 ng gÀ1 lw, respectively, for the low exposure level and 4.6þ/5.7, 7.8þ/6.5, 3.9þ/3.0 and 3.9þ/6.1 mg gÀ1 lw, respectively, for the high exposure level. Isomerization of g-HBCD into a- and b-HBCD was observed in all tissues, at least for the high exposure level. Volatolome data allowed a signiﬁcant discrimination between control and exposed animals whatever the feed contamination load, demonstrating a liver metabolic response to g-HBCD exposure. The relevance of the twenty nine volatile exposure markers tentatively identiﬁed was discussed in light of literature data.

@article{ratel_liver_2017,
	title = {Liver volatolomics to reveal poultry exposure to γ-hexabromocyclododecane ({HBCD})},
	volume = {189},
	issn = {00456535},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S004565351731487X},
	doi = {10.1016/j.chemosphere.2017.09.074},
	abstract = {Hexabromocyclododecane ({HBCD}) is a critical emerging brominated ﬂame retardant to which consumers can be exposed at high doses through a single food intake. Based on an animal experiment involving 3 groups of laying hens fed during 70 days with a control diet or g-{HBCD}-contaminated diets at 0.1 or 10 mg g-{HBCD} {gÀ}1 feed, this study aims to use the volatolome of biological samples for revealing markers of livestock exposure to {HBCD}. Liquid chromatographyetandem mass spectrometry was used to monitor the time-course of {HBCD} levels in bodily samples. Each liver was analyzed by solid-phase microextractionegas chromatographyemass spectrometry for volatolome proﬁling. After 70 days, g-{HBCD} concentrations in egg yolk, fat, liver and serum reached 54 ± 4, 85 ± 6, 31 ± 6, and 32 ± 4 ng {gÀ}1 lw, respectively, for the low exposure level and 4.6þ/5.7, 7.8þ/6.5, 3.9þ/3.0 and 3.9þ/6.1 mg {gÀ}1 lw, respectively, for the high exposure level. Isomerization of g-{HBCD} into a- and b-{HBCD} was observed in all tissues, at least for the high exposure level. Volatolome data allowed a signiﬁcant discrimination between control and exposed animals whatever the feed contamination load, demonstrating a liver metabolic response to g-{HBCD} exposure. The relevance of the twenty nine volatile exposure markers tentatively identiﬁed was discussed in light of literature data.},
	pages = {634--642},
	journaltitle = {Chemosphere},
	author = {Ratel, Jérémy and Planche, Christelle and Mercier, Frédéric and Blinet, Patrick and Kondjoyan, Nathalie and Marchand, Philippe and Fournier, Agnès and Travel, Angélique and Jondreville, Catherine and Engel, Erwan},
	urldate = {2019-03-29},
	date = {2017-12},
	langid = {english},
	file = {Ratel et al. - 2017 - Liver volatolomics to reveal poultry exposure to γ.pdf:C\:\\Users\\ygu\\Documents\\PCPOR066_YGU\\YGU\\Zotero\\storage\\VKMGW3X6\\Ratel et al. - 2017 - Liver volatolomics to reveal poultry exposure to γ.pdf:application/pdf}
}

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