@article{
 title = {Bioinspired, Size-Tunable Self-Assembly of Polymer–Lipid Bilayer Nanodiscs},
 type = {article},
 year = {2017},
 identifiers = {[object Object]},
 keywords = {NMR spectroscopy,lipids,membrane proteins,nanodiscs,polymers},
 volume = {56},
 id = {5b85f22d-ca17-3011-8633-7b7f63945dd0},
 created = {2017-11-26T18:55:15.015Z},
 file_attached = {false},
 profile_id = {19ac30c5-f77a-3ba0-b82a-d16dd951269b},
 last_modified = {2017-11-26T18:58:00.481Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {© 2017 Wiley-VCH Verlag GmbH  &  Co. KGaA, Weinheim Polymer-based nanodiscs are valuable tools in biomedical research that can offer a detergent-free solubilization of membrane proteins maintaining their native lipid environment. Herein, we introduce a novel ca. 1.6 kDa SMA-based polymer with styrene:maleic acid moieties that can form nanodiscs containing a planar lipid bilayer which are useful to reconstitute membrane proteins for structural and functional studies. The physicochemical properties and the mechanism of formation of polymer-based nanodiscs are characterized by light scattering, NMR, FT-IR, and TEM. A remarkable feature is that nanodiscs of different sizes, from nanometer to sub-micrometer diameter, can be produced by varying the lipid-to-polymer ratio. The small-size nanodiscs (up to ca. 30 nm diameter) can be used for solution NMR spectroscopy studies whereas the magnetic-alignment of macro-nanodiscs (diameter of  >  ca. 40 nm) can be exploited for solid-state NMR studies on membrane proteins.},
 bibtype = {article},
 author = {Ravula, T. and Ramadugu, S.K. and Di Mauro, G. and Ramamoorthy, A.},
 journal = {Angewandte Chemie - International Edition},
 number = {38}
}

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