Budesonide reduces hospital admission rates in preschool children with acute wheezing. Razi, C. H., Cörüt, N., & Andıran, N. Pediatric Pulmonology, January, 2017. ![Budesonide reduces hospital admission rates in preschool children with acute wheezing [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BACKGROUND: The object of this study was to determine whether high doses of inhaled budesonide provide additional benefits to a standardized treatment regimen that includes systemic steroids and salbutamol in preschool patients presented to the emergency department (ED) with acute wheezing attacks. Methods This randomized, double-blind, placebo-controlled, parallel group trial was conducted in children, 6 months-6 years with moderate or severe acute wheezing epizode, as determined based on a pulmonary index score (PIS) of 7-13 points. We compared the addition of budesonide 3 mg versus placebo to standard acute asthma treatment, which included salbutamol and a single 1 mg/kg dose of methylprednisolone given at the beginning of therapy. The primary outcome was differences in hospitalization rates within 4 hr. Secondary outcome was difference in median PIS between treatment groups at 2 hr. Results One hundred patients were enrolled. Cumulative hospitalization rate at 120, 180, and 240 min were 0.72, 0.62, and 0.58 in placebo group; and 0.44, 0.30, and 0.24 in budesonide group. Discharged rate in budesonide group was significantly higher than the placebo group (log-rank = 12.407 ve P \textless 0.001). Expected mean discharged times were 200.4 (95%CI = 185.3-215.5) min in placebo group and 164.4 (95%CI = 149.4-179.4) min in budesonide group. Median (25-75%) PIS at the 120th min was significantly lower in budesonide group than the placebo group (5 [4-8] vs. 8 [5-9] respectively, P = 0.006). Conclusions The addition of budesonide nebulization may decrease the admission rate of preschool children who have moderate to severe acute wheezing epizodes. Pediatr Pulmonol. © 2017 Wiley Periodicals, Inc.
@article{razi_budesonide_2017,
title = {Budesonide reduces hospital admission rates in preschool children with acute wheezing},
issn = {1099-0496},
url = {http://sci-hub.cc/10.1002/ppul.23667},
doi = {10.1002/ppul.23667},
abstract = {BACKGROUND: The object of this study was to determine whether high doses of inhaled budesonide provide additional benefits to a standardized treatment regimen that includes systemic steroids and salbutamol in preschool patients presented to the emergency department (ED) with acute wheezing attacks. Methods This randomized, double-blind, placebo-controlled, parallel group trial was conducted in children, 6 months-6 years with moderate or severe acute wheezing epizode, as determined based on a pulmonary index score (PIS) of 7-13 points. We compared the addition of budesonide 3 mg versus placebo to standard acute asthma treatment, which included salbutamol and a single 1 mg/kg dose of methylprednisolone given at the beginning of therapy. The primary outcome was differences in hospitalization rates within 4 hr. Secondary outcome was difference in median PIS between treatment groups at 2 hr. Results One hundred patients were enrolled. Cumulative hospitalization rate at 120, 180, and 240 min were 0.72, 0.62, and 0.58 in placebo group; and 0.44, 0.30, and 0.24 in budesonide group. Discharged rate in budesonide group was significantly higher than the placebo group (log-rank = 12.407 ve P {\textless} 0.001). Expected mean discharged times were 200.4 (95\%CI = 185.3-215.5) min in placebo group and 164.4 (95\%CI = 149.4-179.4) min in budesonide group. Median (25-75\%) PIS at the 120th min was significantly lower in budesonide group than the placebo group (5 [4-8] vs. 8 [5-9] respectively, P = 0.006). Conclusions The addition of budesonide nebulization may decrease the admission rate of preschool children who have moderate to severe acute wheezing epizodes. Pediatr Pulmonol. © 2017 Wiley Periodicals, Inc.},
language = {eng},
journal = {Pediatric Pulmonology},
author = {Razi, Cem Hasan and Cörüt, Nazlı and Andıran, Nesibe},
month = jan,
year = {2017},
pmid = {28085236},
}
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{"_id":"4i4vx59KpBmi7Rq3m","bibbaseid":"razi-crt-andran-budesonidereduceshospitaladmissionratesinpreschoolchildrenwithacutewheezing-2017","author_short":["Razi, C. H.","Cörüt, N.","Andıran, N."],"bibdata":{"bibtype":"article","type":"article","title":"Budesonide reduces hospital admission rates in preschool children with acute wheezing","issn":"1099-0496","url":"http://sci-hub.cc/10.1002/ppul.23667","doi":"10.1002/ppul.23667","abstract":"BACKGROUND: The object of this study was to determine whether high doses of inhaled budesonide provide additional benefits to a standardized treatment regimen that includes systemic steroids and salbutamol in preschool patients presented to the emergency department (ED) with acute wheezing attacks. Methods This randomized, double-blind, placebo-controlled, parallel group trial was conducted in children, 6 months-6 years with moderate or severe acute wheezing epizode, as determined based on a pulmonary index score (PIS) of 7-13 points. We compared the addition of budesonide 3 mg versus placebo to standard acute asthma treatment, which included salbutamol and a single 1 mg/kg dose of methylprednisolone given at the beginning of therapy. The primary outcome was differences in hospitalization rates within 4 hr. Secondary outcome was difference in median PIS between treatment groups at 2 hr. Results One hundred patients were enrolled. Cumulative hospitalization rate at 120, 180, and 240 min were 0.72, 0.62, and 0.58 in placebo group; and 0.44, 0.30, and 0.24 in budesonide group. Discharged rate in budesonide group was significantly higher than the placebo group (log-rank = 12.407 ve P \\textless 0.001). Expected mean discharged times were 200.4 (95%CI = 185.3-215.5) min in placebo group and 164.4 (95%CI = 149.4-179.4) min in budesonide group. Median (25-75%) PIS at the 120th min was significantly lower in budesonide group than the placebo group (5 [4-8] vs. 8 [5-9] respectively, P = 0.006). Conclusions The addition of budesonide nebulization may decrease the admission rate of preschool children who have moderate to severe acute wheezing epizodes. Pediatr Pulmonol. © 2017 Wiley Periodicals, Inc.","language":"eng","journal":"Pediatric Pulmonology","author":[{"propositions":[],"lastnames":["Razi"],"firstnames":["Cem","Hasan"],"suffixes":[]},{"propositions":[],"lastnames":["Cörüt"],"firstnames":["Nazlı"],"suffixes":[]},{"propositions":[],"lastnames":["Andıran"],"firstnames":["Nesibe"],"suffixes":[]}],"month":"January","year":"2017","pmid":"28085236","bibtex":"@article{razi_budesonide_2017,\n\ttitle = {Budesonide reduces hospital admission rates in preschool children with acute wheezing},\n\tissn = {1099-0496},\n\turl = {http://sci-hub.cc/10.1002/ppul.23667},\n\tdoi = {10.1002/ppul.23667},\n\tabstract = {BACKGROUND: The object of this study was to determine whether high doses of inhaled budesonide provide additional benefits to a standardized treatment regimen that includes systemic steroids and salbutamol in preschool patients presented to the emergency department (ED) with acute wheezing attacks. Methods This randomized, double-blind, placebo-controlled, parallel group trial was conducted in children, 6 months-6 years with moderate or severe acute wheezing epizode, as determined based on a pulmonary index score (PIS) of 7-13 points. We compared the addition of budesonide 3 mg versus placebo to standard acute asthma treatment, which included salbutamol and a single 1 mg/kg dose of methylprednisolone given at the beginning of therapy. The primary outcome was differences in hospitalization rates within 4 hr. Secondary outcome was difference in median PIS between treatment groups at 2 hr. Results One hundred patients were enrolled. Cumulative hospitalization rate at 120, 180, and 240 min were 0.72, 0.62, and 0.58 in placebo group; and 0.44, 0.30, and 0.24 in budesonide group. Discharged rate in budesonide group was significantly higher than the placebo group (log-rank = 12.407 ve P {\\textless} 0.001). 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