The mechanism of coupling of the organic anion exchange to Na+-dicarboxylate symport in basolateral membrane vesicles. Rebane, E.; Orlov, Y.; Kazbekov, E.; Lyubimov, Y.; and Bulat, M. Membrane and Cell Biology, 12(1):51-56, 1998. cited By 3
The mechanism of coupling of the organic anion exchange to Na+-dicarboxylate symport in basolateral membrane vesicles [link]Paper  abstract   bibtex   
The rates of p-aminohippurate (PAH) and of uric acid uptake by basolateral membrane vesicles isolated from proximal tubules of rat kidney have been investigated. Accumulation of both substrates against the concentration gradient within the vesicles was shown to occur in the presence of α-ketoglutarate (α-KG) and Na+ gradient in the incubation medium. The mechanism of the coupling between Na+-dicarboxylate symport and organic anion transport is discussed based on the differences between the rates of PAH and of uric acid uptake. It is proposed that the limiting step of coupling between two transporters is the step of α-KG-organic anion exchange.
@ARTICLE{Rebane199851,
author={Rebane, E.N. and Orlov, Y.N. and Kazbekov, E.N. and Lyubimov, Y. and Bulat, M.N.},
title={The mechanism of coupling of the organic anion exchange to Na+-dicarboxylate symport in basolateral membrane vesicles},
journal={Membrane and Cell Biology},
year={1998},
volume={12},
number={1},
pages={51-56},
note={cited By 3},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031739452&partnerID=40&md5=c262e345a14964f5a6b8dee5e93f3bc4},
affiliation={Sechenov Inst Evolutionary Physiol, Russian Academy of Sciences, St. Petersburg, Russian Federation},
abstract={The rates of p-aminohippurate (PAH) and of uric acid uptake by basolateral membrane vesicles isolated from proximal tubules of rat kidney have been investigated. Accumulation of both substrates against the concentration gradient within the vesicles was shown to occur in the presence of α-ketoglutarate (α-KG) and Na+ gradient in the incubation medium. The mechanism of the coupling between Na+-dicarboxylate symport and organic anion transport is discussed based on the differences between the rates of PAH and of uric acid uptake. It is proposed that the limiting step of coupling between two transporters is the step of α-KG-organic anion exchange.},
correspondence_address1={Rebane, E.N.; Sechenov Inst Evolutionary Physiol, Russian Academy of Sciences, St. Petersburg, Russian Federation},
issn={10236597},
coden={MCBIE},
pubmed_id={9829258},
language={English},
abbrev_source_title={Membr. Cell Biol.},
document_type={Article},
source={Scopus},
}
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