Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study. Rebelos, E., Latva-Rasku, A., Koskensalo, K., Pekkarinen, L., Saukko, E., Ihalainen, J., Honka, M. J., Tuisku, J., Bucci, M., Laurila, S., Rajander, J., Salminen, P., Nummenmaa, L., Jansen, J. F., Ferrannini, E., & Nuutila, P. J Cereb Blood Flow Metab, 2023. Rebelos, Eleni Latva-Rasku, Aino Koskensalo, Kalle Pekkarinen, Laura Saukko, Ekaterina Ihalainen, Jukka Honka, Miikka-Juhani Tuisku, Jouni Bucci, Marco Laurila, Sanna Rajander, Johan Salminen, Paulina Nummenmaa, Lauri Jansen, Jacobus Fa Ferrannini, Ele Nuutila, Pirjo eng J Cereb Blood Flow Metab. 2023 Oct 12:271678X231207114. doi: 10.1177/0271678X231207114.![Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The human brain undergoes metabolic adaptations in obesity, but the underlying mechanisms have remained largely unknown. We compared concentrations of often reported brain metabolites measured with magnetic resonance spectroscopy ((1)H-MRS, 3 T MRI) in the occipital lobe in subjects with obesity and lean controls under different metabolic conditions (fasting, insulin clamp, following weight loss). Brain glucose uptake (BGU) quantified with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET)) was also performed in a subset of subjects during clamp. In dataset A, 48 participants were studied during fasting with brain (1)H-MRS, while in dataset B 21 participants underwent paired brain (1)H-MRS acquisitions under fasting and clamp conditions. In dataset C 16 subjects underwent brain (18)F-FDG-PET and (1)H-MRS during clamp. In the fasting state, total N-acetylaspartate was lower in subjects with obesity, while brain myo-inositol increased in response to hyperinsulinemia similarly in both lean participants and subjects with obesity. During clamp, BGU correlated positively with brain glutamine/glutamate, total choline, and total creatine levels. Following weight loss, brain creatine levels were increased, whereas increases in other metabolites remained not significant. To conclude, insulin signaling and glucose metabolism are significantly coupled with several of the changes in brain metabolites that occur in obesity.
@article{RN342,
author = {Rebelos, E. and Latva-Rasku, A. and Koskensalo, K. and Pekkarinen, L. and Saukko, E. and Ihalainen, J. and Honka, M. J. and Tuisku, J. and Bucci, M. and Laurila, S. and Rajander, J. and Salminen, P. and Nummenmaa, L. and Jansen, J. F. and Ferrannini, E. and Nuutila, P.},
title = {Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study},
journal = {J Cereb Blood Flow Metab},
pages = {271678X231207114},
note = {Rebelos, Eleni
Latva-Rasku, Aino
Koskensalo, Kalle
Pekkarinen, Laura
Saukko, Ekaterina
Ihalainen, Jukka
Honka, Miikka-Juhani
Tuisku, Jouni
Bucci, Marco
Laurila, Sanna
Rajander, Johan
Salminen, Paulina
Nummenmaa, Lauri
Jansen, Jacobus Fa
Ferrannini, Ele
Nuutila, Pirjo
eng
J Cereb Blood Flow Metab. 2023 Oct 12:271678X231207114. doi: 10.1177/0271678X231207114.},
abstract = {The human brain undergoes metabolic adaptations in obesity, but the underlying mechanisms have remained largely unknown. We compared concentrations of often reported brain metabolites measured with magnetic resonance spectroscopy ((1)H-MRS, 3 T MRI) in the occipital lobe in subjects with obesity and lean controls under different metabolic conditions (fasting, insulin clamp, following weight loss). Brain glucose uptake (BGU) quantified with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET)) was also performed in a subset of subjects during clamp. In dataset A, 48 participants were studied during fasting with brain (1)H-MRS, while in dataset B 21 participants underwent paired brain (1)H-MRS acquisitions under fasting and clamp conditions. In dataset C 16 subjects underwent brain (18)F-FDG-PET and (1)H-MRS during clamp. In the fasting state, total N-acetylaspartate was lower in subjects with obesity, while brain myo-inositol increased in response to hyperinsulinemia similarly in both lean participants and subjects with obesity. During clamp, BGU correlated positively with brain glutamine/glutamate, total choline, and total creatine levels. Following weight loss, brain creatine levels were increased, whereas increases in other metabolites remained not significant. To conclude, insulin signaling and glucose metabolism are significantly coupled with several of the changes in brain metabolites that occur in obesity.},
keywords = {N-acetyl-aspartate
Positron emission tomography
insulin resistance
magnetic resonance spectroscopy
myo-inositol
obesity
of interest with respect to the research, authorship, and/or publication of this
article.},
ISSN = {1559-7016 (Electronic)
0271-678X (Linking)},
DOI = {10.1177/0271678X231207114},
url = {https://www.ncbi.nlm.nih.gov/pubmed/37824728},
year = {2023},
type = {Journal Article}
}
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We compared concentrations of often reported brain metabolites measured with magnetic resonance spectroscopy ((1)H-MRS, 3 T MRI) in the occipital lobe in subjects with obesity and lean controls under different metabolic conditions (fasting, insulin clamp, following weight loss). Brain glucose uptake (BGU) quantified with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET)) was also performed in a subset of subjects during clamp. In dataset A, 48 participants were studied during fasting with brain (1)H-MRS, while in dataset B 21 participants underwent paired brain (1)H-MRS acquisitions under fasting and clamp conditions. In dataset C 16 subjects underwent brain (18)F-FDG-PET and (1)H-MRS during clamp. In the fasting state, total N-acetylaspartate was lower in subjects with obesity, while brain myo-inositol increased in response to hyperinsulinemia similarly in both lean participants and subjects with obesity. 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J. and Tuisku, J. and Bucci, M. and Laurila, S. and Rajander, J. and Salminen, P. and Nummenmaa, L. and Jansen, J. F. and Ferrannini, E. and Nuutila, P.},\n title = {Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study},\n journal = {J Cereb Blood Flow Metab},\n pages = {271678X231207114},\n note = {Rebelos, Eleni\nLatva-Rasku, Aino\nKoskensalo, Kalle\nPekkarinen, Laura\nSaukko, Ekaterina\nIhalainen, Jukka\nHonka, Miikka-Juhani\nTuisku, Jouni\nBucci, Marco\nLaurila, Sanna\nRajander, Johan\nSalminen, Paulina\nNummenmaa, Lauri\nJansen, Jacobus Fa\nFerrannini, Ele\nNuutila, Pirjo\neng\nJ Cereb Blood Flow Metab. 2023 Oct 12:271678X231207114. doi: 10.1177/0271678X231207114.},\n abstract = {The human brain undergoes metabolic adaptations in obesity, but the underlying mechanisms have remained largely unknown. 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