Aminophylline in Bronchial Asthma. Rees, H. A., Borthwick, R. C., Millar, J. S., & Donald, K. W. The Lancet, 290(7527):1167–1169, December, 1967.
Aminophylline in Bronchial Asthma [link]Paper  doi  abstract   bibtex   
Aminophylline given to chronic wheezy asthmatic patients relieved airway obstruction but had an unpredictable effect on PaO2. In many cases, existing hypoxæmia was worsened. Changes in PaO2 seemed to be related to changes in ventilation-perfusion relationships, which initially were abnormal in most of the patients. The administration of the drug to controls increased PaO2 without altering the forced expiratory volume in 1 second.
@article{rees_aminophylline_1967,
	series = {Originally published as {Volume} 2, {Issue} 7527},
	title = {Aminophylline in {Bronchial} {Asthma}},
	volume = {290},
	issn = {0140-6736},
	url = {http://www.sciencedirect.com/science/article/pii/S0140673667918909},
	doi = {10.1016/S0140-6736(67)91890-9},
	abstract = {Aminophylline given to chronic wheezy asthmatic patients relieved airway obstruction but had an unpredictable effect on PaO2. In many cases, existing hypoxæmia was worsened. Changes in PaO2 seemed to be related to changes in ventilation-perfusion relationships, which initially were abnormal in most of the patients. The administration of the drug to controls increased PaO2 without altering the forced expiratory volume in 1 second.},
	number = {7527},
	urldate = {2014-09-29},
	journal = {The Lancet},
	author = {Rees, H. A. and Borthwick, R. C. and Millar, J. S. and Donald, K. W.},
	month = dec,
	year = {1967},
	pages = {1167--1169},
}

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