Natural polymorphisms in Mycobacterium tuberculosis conferring resistance to delamanid in drug-naïve patients

Natural polymorphisms in Mycobacterium tuberculosis conferring resistance to delamanid in drug-naïve patients. Reichmuth, M. L, Hömke, R., Zürcher, K., Sander, P., Avihingsanon, A., Collantes, J., Loiseau, C., Borrell, S., Reinhard, M., Wilkinson, R. J, Yotebieng, M., Fenner, L., Böttger, E. C, Gagneux, S., Egger, M., & Keller, P. M Antimicrobial Agents and Chemotherapy, 64(11):e00513–20, American Society for Microbiology Journals, aug, 2020.

Paper doi abstract bibtex

Mutations in the genes of the F 420 signaling pathway, including dnn , fgd1 , fbiA , fbiB , fbiC , and fbiD, of Mycobacterium tuberculosis ( Mtb ) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For ten strains with mutations, we determined the minimum inhibitory concentration (MIC) of delamanid. We found one strain from a delamanid-naïve patient carrying the natural polymorphism Tyr29del ( ddn ) that was associated with a critical MIC to delamanid.

@article{Reichmuth2020,
abstract = {Mutations in the genes of the F 420 signaling pathway, including dnn , fgd1 , fbiA , fbiB , fbiC , and fbiD, of Mycobacterium tuberculosis ( Mtb ) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54{\%}) strains had at least one mutation in one of the genes. For ten strains with mutations, we determined the minimum inhibitory concentration (MIC) of delamanid. We found one strain from a delamanid-na{\"{i}}ve patient carrying the natural polymorphism Tyr29del ( ddn ) that was associated with a critical MIC to delamanid.},
author = {Reichmuth, Martina L and H{\"{o}}mke, Rico and Z{\"{u}}rcher, Kathrin and Sander, Peter and Avihingsanon, Anchalee and Collantes, Jimena and Loiseau, Chlo{\'{e}} and Borrell, Sonia and Reinhard, Miriam and Wilkinson, Robert J and Yotebieng, Marcel and Fenner, Lukas and B{\"{o}}ttger, Erik C and Gagneux, Sebastien and Egger, Matthias and Keller, Peter M},
doi = {10.1128/AAC.00513-20},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Reichmuth et al. - 2020 - Natural polymorphisms in iMycobacterium tuberculosisi conferring resistance to delamanid in drug-na{\"{i}}ve patient.pdf:pdf},
issn = {0066-4804},
journal = {Antimicrobial Agents and Chemotherapy},
keywords = {OA,fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,original},
month = {aug},
number = {11},
pages = {e00513--20},
pmid = {32868333},
publisher = {American Society for Microbiology Journals},
title = {{Natural polymorphisms in \textit{Mycobacterium tuberculosis} conferring resistance to delamanid in drug-na{\"{i}}ve patients}},
url = {http://aac.asm.org/lookup/doi/10.1128/AAC.00513-20},
volume = {64},
year = {2020}
}

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