@article{rempe_hemisphere-_2025, title = {Hemisphere- and condition-specific alpha oscillations support semantic and spatial cognition in aging.}, copyright = {© 2025. The Author(s), under exclusive licence to American Aging Association.}, issn = {2509-2723}, doi = {10.1007/s11357-025-01651-4}, abstract = {Neuroimaging studies have shown age-related alterations in brain structure and function supporting semantic knowledge, although the significance of these is not fully understood. Herein, we report novel temporal, spectral, and spatial information on age-related changes from the largest dynamic functional mapping study of semantic processing. Participants (N = 130, age range 21-87 years, M(age) = 51.05, SD = 14.73, 68 females) performed a semantic judgement task during magnetoencephalography (MEG), and significant task-related oscillatory responses were projected into anatomical space using a beamformer. Voxel-wise linear mixed-effects models were performed to assess semantic-related neural oscillations, irrespective of and influenced by age. Mediation analyses were performed to assess if local oscillations mediated the relationship between age and reaction time. Whole-brain analyses revealed stronger left-lateralized alpha/beta oscillations in frontotemporal cortices during semantic trials and stronger right-lateralized alpha/beta responses in temporoparietal regions during length trials (all ps {\textless}.001). Older adults showed stronger left temporoparietal alpha and left frontal beta during semantic processing and stronger alpha in the right temporal cortex during the length condition (all ps {\textless}.001). Alpha oscillations further mediated the relationship between age and reaction time in a hemisphere- and condition-specific manner, whereby right temporal activity mediated the age-behavior relationship in the length but not semantic condition (Z = 2.01, p =.022), while left temporoparietal activity significantly mediated this relationship in the semantic but not length condition (Z =  - 2.41, p =.008). Altogether, our findings demonstrate accentuated oscillations in aging which are hemisphere- and condition-specific and support compensatory processing to aid in maintaining adequate behavioral performance, lending clear support to leading neuroscientific models of aging.}, language = {eng}, journal = {GeroScience}, author = {Rempe, Maggie P. and Manta, Danae S. and Cohen, Kayle and Glesinger, Ryan J. and Okelberry, Hannah J. and John, Jason A. and Coutant, Anna T. and Horne, Lucy K. and Garrison, Grant M. and Kress, Kennedy A. and Weyrich, Lucas and Casagrande, Chloe C. and Willett, Madelyn P. and Johnson, Hallie J. and Wiesman, Alex I. and Heinrichs-Graham, Elizabeth and Spooner, Rachel K. and Embury, Christine M. and Wilson, Tony W.}, month = apr, year = {2025}, pmid = {40205170}, note = {Place: Switzerland}, }

{"_id":"iCQj5dupuSa2WACat","bibbaseid":"rempe-manta-cohen-glesinger-okelberry-john-coutant-horne-etal-hemisphereandconditionspecificalphaoscillationssupportsemanticandspatialcognitioninaging-2025","author_short":["Rempe, M. P.","Manta, D. S.","Cohen, K.","Glesinger, R. J.","Okelberry, H. J.","John, J. A.","Coutant, A. T.","Horne, L. K.","Garrison, G. M.","Kress, K. A.","Weyrich, L.","Casagrande, C. C.","Willett, M. P.","Johnson, H. J.","Wiesman, A. I.","Heinrichs-Graham, E.","Spooner, R. K.","Embury, C. M.","Wilson, T. W."],"bibdata":{"bibtype":"article","type":"article","title":"Hemisphere- and condition-specific alpha oscillations support semantic and spatial cognition in aging.","copyright":"© 2025. The Author(s), under exclusive licence to American Aging Association.","issn":"2509-2723","doi":"10.1007/s11357-025-01651-4","abstract":"Neuroimaging studies have shown age-related alterations in brain structure and function supporting semantic knowledge, although the significance of these is not fully understood. Herein, we report novel temporal, spectral, and spatial information on age-related changes from the largest dynamic functional mapping study of semantic processing. Participants (N = 130, age range 21-87 years, M(age) = 51.05, SD = 14.73, 68 females) performed a semantic judgement task during magnetoencephalography (MEG), and significant task-related oscillatory responses were projected into anatomical space using a beamformer. Voxel-wise linear mixed-effects models were performed to assess semantic-related neural oscillations, irrespective of and influenced by age. Mediation analyses were performed to assess if local oscillations mediated the relationship between age and reaction time. Whole-brain analyses revealed stronger left-lateralized alpha/beta oscillations in frontotemporal cortices during semantic trials and stronger right-lateralized alpha/beta responses in temporoparietal regions during length trials (all ps \\textless.001). Older adults showed stronger left temporoparietal alpha and left frontal beta during semantic processing and stronger alpha in the right temporal cortex during the length condition (all ps \\textless.001). Alpha oscillations further mediated the relationship between age and reaction time in a hemisphere- and condition-specific manner, whereby right temporal activity mediated the age-behavior relationship in the length but not semantic condition (Z = 2.01, p =.022), while left temporoparietal activity significantly mediated this relationship in the semantic but not length condition (Z =  - 2.41, p =.008). Altogether, our findings demonstrate accentuated oscillations in aging which are hemisphere- and condition-specific and support compensatory processing to aid in maintaining adequate behavioral performance, lending clear support to leading neuroscientific models of aging.","language":"eng","journal":"GeroScience","author":[{"propositions":[],"lastnames":["Rempe"],"firstnames":["Maggie","P."],"suffixes":[]},{"propositions":[],"lastnames":["Manta"],"firstnames":["Danae","S."],"suffixes":[]},{"propositions":[],"lastnames":["Cohen"],"firstnames":["Kayle"],"suffixes":[]},{"propositions":[],"lastnames":["Glesinger"],"firstnames":["Ryan","J."],"suffixes":[]},{"propositions":[],"lastnames":["Okelberry"],"firstnames":["Hannah","J."],"suffixes":[]},{"propositions":[],"lastnames":["John"],"firstnames":["Jason","A."],"suffixes":[]},{"propositions":[],"lastnames":["Coutant"],"firstnames":["Anna","T."],"suffixes":[]},{"propositions":[],"lastnames":["Horne"],"firstnames":["Lucy","K."],"suffixes":[]},{"propositions":[],"lastnames":["Garrison"],"firstnames":["Grant","M."],"suffixes":[]},{"propositions":[],"lastnames":["Kress"],"firstnames":["Kennedy","A."],"suffixes":[]},{"propositions":[],"lastnames":["Weyrich"],"firstnames":["Lucas"],"suffixes":[]},{"propositions":[],"lastnames":["Casagrande"],"firstnames":["Chloe","C."],"suffixes":[]},{"propositions":[],"lastnames":["Willett"],"firstnames":["Madelyn","P."],"suffixes":[]},{"propositions":[],"lastnames":["Johnson"],"firstnames":["Hallie","J."],"suffixes":[]},{"propositions":[],"lastnames":["Wiesman"],"firstnames":["Alex","I."],"suffixes":[]},{"propositions":[],"lastnames":["Heinrichs-Graham"],"firstnames":["Elizabeth"],"suffixes":[]},{"propositions":[],"lastnames":["Spooner"],"firstnames":["Rachel","K."],"suffixes":[]},{"propositions":[],"lastnames":["Embury"],"firstnames":["Christine","M."],"suffixes":[]},{"propositions":[],"lastnames":["Wilson"],"firstnames":["Tony","W."],"suffixes":[]}],"month":"April","year":"2025","pmid":"40205170","note":"Place: Switzerland","bibtex":"@article{rempe_hemisphere-_2025, title = {Hemisphere- and condition-specific alpha oscillations support semantic and spatial cognition in aging.}, copyright = {© 2025. The Author(s), under exclusive licence to American Aging Association.}, issn = {2509-2723}, doi = {10.1007/s11357-025-01651-4}, abstract = {Neuroimaging studies have shown age-related alterations in brain structure and function supporting semantic knowledge, although the significance of these is not fully understood. Herein, we report novel temporal, spectral, and spatial information on age-related changes from the largest dynamic functional mapping study of semantic processing. Participants (N = 130, age range 21-87 years, M(age) = 51.05, SD = 14.73, 68 females) performed a semantic judgement task during magnetoencephalography (MEG), and significant task-related oscillatory responses were projected into anatomical space using a beamformer. Voxel-wise linear mixed-effects models were performed to assess semantic-related neural oscillations, irrespective of and influenced by age. Mediation analyses were performed to assess if local oscillations mediated the relationship between age and reaction time. Whole-brain analyses revealed stronger left-lateralized alpha/beta oscillations in frontotemporal cortices during semantic trials and stronger right-lateralized alpha/beta responses in temporoparietal regions during length trials (all ps {\\textless}.001). Older adults showed stronger left temporoparietal alpha and left frontal beta during semantic processing and stronger alpha in the right temporal cortex during the length condition (all ps {\\textless}.001). Alpha oscillations further mediated the relationship between age and reaction time in a hemisphere- and condition-specific manner, whereby right temporal activity mediated the age-behavior relationship in the length but not semantic condition (Z = 2.01, p =.022), while left temporoparietal activity significantly mediated this relationship in the semantic but not length condition (Z =  - 2.41, p =.008). Altogether, our findings demonstrate accentuated oscillations in aging which are hemisphere- and condition-specific and support compensatory processing to aid in maintaining adequate behavioral performance, lending clear support to leading neuroscientific models of aging.}, language = {eng}, journal = {GeroScience}, author = {Rempe, Maggie P. and Manta, Danae S. and Cohen, Kayle and Glesinger, Ryan J. and Okelberry, Hannah J. and John, Jason A. and Coutant, Anna T. and Horne, Lucy K. and Garrison, Grant M. and Kress, Kennedy A. and Weyrich, Lucas and Casagrande, Chloe C. and Willett, Madelyn P. and Johnson, Hallie J. and Wiesman, Alex I. and Heinrichs-Graham, Elizabeth and Spooner, Rachel K. and Embury, Christine M. and Wilson, Tony W.}, month = apr, year = {2025}, pmid = {40205170}, note = {Place: Switzerland}, } ","author_short":["Rempe, M. P.","Manta, D. S.","Cohen, K.","Glesinger, R. J.","Okelberry, H. J.","John, J. A.","Coutant, A. T.","Horne, L. K.","Garrison, G. M.","Kress, K. A.","Weyrich, L.","Casagrande, C. C.","Willett, M. P.","Johnson, H. J.","Wiesman, A. I.","Heinrichs-Graham, E.","Spooner, R. K.","Embury, C. M.","Wilson, T. W."],"key":"rempe_hemisphere-_2025","id":"rempe_hemisphere-_2025","bibbaseid":"rempe-manta-cohen-glesinger-okelberry-john-coutant-horne-etal-hemisphereandconditionspecificalphaoscillationssupportsemanticandspatialcognitioninaging-2025","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/BrK4SFD8bduuo36Fb","dataSources":["aQ3pBXF2RHyQxzH4J"],"keywords":[],"search_terms":["hemisphere","condition","specific","alpha","oscillations","support","semantic","spatial","cognition","aging","rempe","manta","cohen","glesinger","okelberry","john","coutant","horne","garrison","kress","weyrich","casagrande","willett","johnson","wiesman","heinrichs-graham","spooner","embury","wilson"],"title":"Hemisphere- and condition-specific alpha oscillations support semantic and spatial cognition in aging.","year":2025}