Tiny telomere DNA. Ren, J., Qu, X., Trent, J. O, & Chaires, J. B Nucleic acids research, 30(11):2307–15, July, 2002.
Paper abstract bibtex We describe the design, synthesis and biophysical characterization of a novel DNA construct in which a folded quadruplex structure is joined to a standard double helix. Circular dichroism, gel electrophoresis, three-dimensional UV melting and differential scanning calorimetry were all used to characterize the structure. Rigorous molecular dynamics simulations were used to build a plausible atomic-level structural model of the DNA construct. This novel DNA construct provides a model for the duplex-quadruplex junction region at the end of chromosomal DNA and offers a system for the study of structure-selective ligand binding.
@article{Ren2002,
title = {Tiny telomere {DNA}.},
volume = {30},
issn = {1362-4962},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117210&tool=pmcentrez&rendertype=abstract},
abstract = {We describe the design, synthesis and biophysical characterization of a novel DNA construct in which a folded quadruplex structure is joined to a standard double helix. Circular dichroism, gel electrophoresis, three-dimensional UV melting and differential scanning calorimetry were all used to characterize the structure. Rigorous molecular dynamics simulations were used to build a plausible atomic-level structural model of the DNA construct. This novel DNA construct provides a model for the duplex-quadruplex junction region at the end of chromosomal DNA and offers a system for the study of structure-selective ligand binding.},
number = {11},
journal = {Nucleic acids research},
author = {Ren, Jinsong and Qu, Xiaogang and Trent, John O and Chaires, Jonathan B},
month = jul,
year = {2002},
pmid = {12034817},
keywords = {\#nosource, Base Sequence, Calorimetry, Circular Dichroism, DNA, DNA: chemistry, DNA: genetics, DNA: metabolism, DNA: radiation effects, Differential Scanning, Fluorescence, G-Quadruplexes, Ligands, Models, Molecular, Nucleic Acid Conformation, Nucleic Acid Conformation: radiation effects, Nucleic Acid Denaturation, Nucleic Acid Denaturation: radiation effects, Oligodeoxyribonucleotides, Oligodeoxyribonucleotides: chemistry, Oligodeoxyribonucleotides: genetics, Oligodeoxyribonucleotides: metabolism, Oligodeoxyribonucleotides: radiation effects, Spectrometry, Telomere, Telomere: chemistry, Telomere: genetics, Telomere: metabolism, Telomere: radiation effects, Thermodynamics, Ultraviolet Rays},
pages = {2307--15},
}
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