@article{RN232,
   author = {Rensma, S. P. and van Sloten, T. T. and Houben, Ajhm and Kohler, S. and van Boxtel, M. P. J. and Berendschot, Ttjm and Jansen, J. F. A. and Verhey, F. R. J. and Kroon, A. A. and Koster, A. and Backes, W. H. and Schaper, N. and Dinant, G. J. and Schalkwijk, C. G. and Henry, R. M. A. and Wolfs, E. M. L. and van Heumen, M. J. A. and Schram, M. T. and Stehouwer, C. D. A.},
   title = {Microvascular Dysfunction Is Associated With Worse Cognitive Performance: The Maastricht Study},
   journal = {Hypertension},
   volume = {75},
   number = {1},
   pages = {237-245},
   note = {Rensma, Sytze P
van Sloten, Thomas T
Houben, Alfons J H M
Kohler, Sebastian
van Boxtel, Martin P J
Berendschot, Tos T J M
Jansen, Jacobus F A
Verhey, Frans R J
Kroon, Abraham A
Koster, Annemarie
Backes, Walter H
Schaper, Nicolaas
Dinant, Geert-Jan
Schalkwijk, Casper G
Henry, Ronald M A
Wolfs, Elze M L
van Heumen, Mike J A
Schram, Miranda T
Stehouwer, Coen D A
eng
2019/11/19 06:00
Hypertension. 2020 Jan;75(1):237-245. doi: 10.1161/HYPERTENSIONAHA.119.13023. Epub 2019 Nov 18.},
   abstract = {Microvascular dysfunction may be associated with worse cognitive performance. Most previous studies did not adjust for important confounders, evaluated only individual measures of microvascular dysfunction, and showed inconsistent results. We evaluated the association between a comprehensive set of measures of microvascular dysfunction and cognitive performance in the population-based Maastricht Study. We used cross-sectional data including 3011 participants (age 59.5+/-8.2; 48.9% women; 26.5% type 2 diabetes mellitus [oversampled by design]). Measures of microvascular dysfunction included magnetic resonance imaging features of cerebral small vessel disease, plasma biomarkers of microvascular dysfunction, albuminuria, flicker light-induced retinal arteriolar and venular dilation response and heat-induced skin hyperemia. These measures were summarized into a microvascular dysfunction composite score. Cognitive domains assessed were memory, processing speed, and executive function. A cognitive function score was calculated as the sum of the scores on these 3 cognitive domains. The microvascular dysfunction score was associated with a worse cognitive function score (standardized beta, -0.087 [95% CI, -0.127 to -0.047]), independent of age, education level, sex, type 2 diabetes mellitus, smoking, alcohol use, hypertension, total/HDL (high-density lipoprotein) cholesterol ratio, triglycerides, lipid-modifying medication, prior cardiovascular disease, depression and plasma biomarkers of low-grade inflammation. The fully adjusted beta-coefficient of the association between the microvascular dysfunction score and the cognitive function score was equivalent to 2 (range, 1-3) years of aging for each SD higher microvascular dysfunction score. The microvascular dysfunction score was associated with worse memory and processing speed but not with worse executive function. The present study shows that microvascular dysfunction is associated with worse cognitive performance.},
   keywords = {blood pressure
cerebral small vessel disease
cognition
dilation
hyperemia
hypertension
microcirculation},
   ISSN = {1524-4563 (Electronic)
0194-911X (Linking)},
   DOI = {10.1161/HYPERTENSIONAHA.119.13023},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/31735081},
   year = {2020},
   type = {Journal Article}
}

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A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Rensma"],"firstnames":["S.","P."],"suffixes":[]},{"propositions":["van"],"lastnames":["Sloten"],"firstnames":["T.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Houben"],"firstnames":["Ajhm"],"suffixes":[]},{"propositions":[],"lastnames":["Kohler"],"firstnames":["S."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Berendschot"],"firstnames":["Ttjm"],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Verhey"],"firstnames":["F.","R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Kroon"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Koster"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Schaper"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Dinant"],"firstnames":["G.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Schalkwijk"],"firstnames":["C.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Henry"],"firstnames":["R.","M.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Wolfs"],"firstnames":["E.","M.","L."],"suffixes":[]},{"propositions":["van"],"lastnames":["Heumen"],"firstnames":["M.","J.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D.","A."],"suffixes":[]}],"title":"Microvascular Dysfunction Is Associated With Worse Cognitive Performance: The Maastricht Study","journal":"Hypertension","volume":"75","number":"1","pages":"237-245","note":"Rensma, Sytze P van Sloten, Thomas T Houben, Alfons J H M Kohler, Sebastian van Boxtel, Martin P J Berendschot, Tos T J M Jansen, Jacobus F A Verhey, Frans R J Kroon, Abraham A Koster, Annemarie Backes, Walter H Schaper, Nicolaas Dinant, Geert-Jan Schalkwijk, Casper G Henry, Ronald M A Wolfs, Elze M L van Heumen, Mike J A Schram, Miranda T Stehouwer, Coen D A eng 2019/11/19 06:00 Hypertension. 2020 Jan;75(1):237-245. doi: 10.1161/HYPERTENSIONAHA.119.13023. Epub 2019 Nov 18.","abstract":"Microvascular dysfunction may be associated with worse cognitive performance. Most previous studies did not adjust for important confounders, evaluated only individual measures of microvascular dysfunction, and showed inconsistent results. We evaluated the association between a comprehensive set of measures of microvascular dysfunction and cognitive performance in the population-based Maastricht Study. We used cross-sectional data including 3011 participants (age 59.5+/-8.2; 48.9% women; 26.5% type 2 diabetes mellitus [oversampled by design]). Measures of microvascular dysfunction included magnetic resonance imaging features of cerebral small vessel disease, plasma biomarkers of microvascular dysfunction, albuminuria, flicker light-induced retinal arteriolar and venular dilation response and heat-induced skin hyperemia. These measures were summarized into a microvascular dysfunction composite score. Cognitive domains assessed were memory, processing speed, and executive function. A cognitive function score was calculated as the sum of the scores on these 3 cognitive domains. The microvascular dysfunction score was associated with a worse cognitive function score (standardized beta, -0.087 [95% CI, -0.127 to -0.047]), independent of age, education level, sex, type 2 diabetes mellitus, smoking, alcohol use, hypertension, total/HDL (high-density lipoprotein) cholesterol ratio, triglycerides, lipid-modifying medication, prior cardiovascular disease, depression and plasma biomarkers of low-grade inflammation. The fully adjusted beta-coefficient of the association between the microvascular dysfunction score and the cognitive function score was equivalent to 2 (range, 1-3) years of aging for each SD higher microvascular dysfunction score. The microvascular dysfunction score was associated with worse memory and processing speed but not with worse executive function. The present study shows that microvascular dysfunction is associated with worse cognitive performance.","keywords":"blood pressure cerebral small vessel disease cognition dilation hyperemia hypertension microcirculation","issn":"1524-4563 (Electronic) 0194-911X (Linking)","doi":"10.1161/HYPERTENSIONAHA.119.13023","url":"http://www.ncbi.nlm.nih.gov/pubmed/31735081","year":"2020","bibtex":"@article{RN232,\n author = {Rensma, S. P. and van Sloten, T. T. and Houben, Ajhm and Kohler, S. and van Boxtel, M. P. J. and Berendschot, Ttjm and Jansen, J. F. A. and Verhey, F. R. J. and Kroon, A. A. and Koster, A. and Backes, W. H. and Schaper, N. and Dinant, G. J. and Schalkwijk, C. G. and Henry, R. M. A. and Wolfs, E. M. L. and van Heumen, M. J. A. and Schram, M. T. and Stehouwer, C. D. A.},\n title = {Microvascular Dysfunction Is Associated With Worse Cognitive Performance: The Maastricht Study},\n journal = {Hypertension},\n volume = {75},\n number = {1},\n pages = {237-245},\n note = {Rensma, Sytze P\nvan Sloten, Thomas T\nHouben, Alfons J H M\nKohler, Sebastian\nvan Boxtel, Martin P J\nBerendschot, Tos T J M\nJansen, Jacobus F A\nVerhey, Frans R J\nKroon, Abraham A\nKoster, Annemarie\nBackes, Walter H\nSchaper, Nicolaas\nDinant, Geert-Jan\nSchalkwijk, Casper G\nHenry, Ronald M A\nWolfs, Elze M L\nvan Heumen, Mike J A\nSchram, Miranda T\nStehouwer, Coen D A\neng\n2019/11/19 06:00\nHypertension. 2020 Jan;75(1):237-245. doi: 10.1161/HYPERTENSIONAHA.119.13023. Epub 2019 Nov 18.},\n abstract = {Microvascular dysfunction may be associated with worse cognitive performance. Most previous studies did not adjust for important confounders, evaluated only individual measures of microvascular dysfunction, and showed inconsistent results. We evaluated the association between a comprehensive set of measures of microvascular dysfunction and cognitive performance in the population-based Maastricht Study. We used cross-sectional data including 3011 participants (age 59.5+/-8.2; 48.9% women; 26.5% type 2 diabetes mellitus [oversampled by design]). Measures of microvascular dysfunction included magnetic resonance imaging features of cerebral small vessel disease, plasma biomarkers of microvascular dysfunction, albuminuria, flicker light-induced retinal arteriolar and venular dilation response and heat-induced skin hyperemia. These measures were summarized into a microvascular dysfunction composite score. Cognitive domains assessed were memory, processing speed, and executive function. A cognitive function score was calculated as the sum of the scores on these 3 cognitive domains. The microvascular dysfunction score was associated with a worse cognitive function score (standardized beta, -0.087 [95% CI, -0.127 to -0.047]), independent of age, education level, sex, type 2 diabetes mellitus, smoking, alcohol use, hypertension, total/HDL (high-density lipoprotein) cholesterol ratio, triglycerides, lipid-modifying medication, prior cardiovascular disease, depression and plasma biomarkers of low-grade inflammation. The fully adjusted beta-coefficient of the association between the microvascular dysfunction score and the cognitive function score was equivalent to 2 (range, 1-3) years of aging for each SD higher microvascular dysfunction score. The microvascular dysfunction score was associated with worse memory and processing speed but not with worse executive function. The present study shows that microvascular dysfunction is associated with worse cognitive performance.},\n keywords = {blood pressure\ncerebral small vessel disease\ncognition\ndilation\nhyperemia\nhypertension\nmicrocirculation},\n ISSN = {1524-4563 (Electronic)\n0194-911X (Linking)},\n DOI = {10.1161/HYPERTENSIONAHA.119.13023},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/31735081},\n year = {2020},\n type = {Journal Article}\n}\n\n","author_short":["Rensma, S. P.","van Sloten, T. T.","Houben, A.","Kohler, S.","van Boxtel, M. P. J.","Berendschot, T.","Jansen, J. F. A.","Verhey, F. R. J.","Kroon, A. A.","Koster, A.","Backes, W. H.","Schaper, N.","Dinant, G. J.","Schalkwijk, C. G.","Henry, R. M. A.","Wolfs, E. M. L.","van Heumen, M. J. A.","Schram, M. T.","Stehouwer, C. D. 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